Results 131 to 140 of about 364,472 (353)

A Superhydrophobic 3D Cell Culture System Reveals the Mechanobiological Role of Cancer‐Associated Fibroblasts in Prostate Cancer Metastasis

Advanced Healthcare Materials, EarlyView.
A superhydrophobic 3D cell culture platform enables rapid and consistent formation of heterotypic tumor–stroma clusters, and reveals how physiological shear conditions influence metastatic signaling. Mechanical stimulation of cancer‐associated fibroblasts promotes sustained cytokine secretion and survival‐promoting pathways, showing how multicellular ...
Alexandria T. Carter, Abigail R. Fabiano, Ehsan Aalaei, Jason Deng, Dakota E. Rostant, Michael R. King   +5 more
wiley   +1 more source

Vascular Endothelial Growth Factor (VEGF) Signaling in Tumour Vascularization: Potential and Challenges

Current Vascular Pharmacology, 2017
Angiogenesis is defined as the physiological process by which new blood vessels develop from pre-existing vessels; either by sprouting or intussusception. Inhibition of angiogenesis is one of the most encouraging strategies to manage the growth and metastasis of cancers.
Siveen, Kodappully Sivaraman, Prabhu, Kirti, Krishnankutty, Roopesh, Kuttikrishnan, Shilpa, Tsakou, Magdalini, Alali, Feras Q., Dermime, Said, Mohammad, Ramzi M., Uddin, Shahab   +8 more
openaire   +4 more sources

A Physiological Microfluidic Blood–Brain‐Barrier Model for In Vitro Study of Nanoparticle Trafficking and Accumulation

Advanced Healthcare Materials, EarlyView.
A human microfluidic blood‐brain barrier (mBBB) model enables spatially resolved comparison of nanoparticle trafficking. Extracellular vesicles (EVs), liposomes, and nanoplastics exhibit distinct transport and disruption behaviors, revealing that membrane composition and uptake pathways govern BBB interaction.
Bryan B. Nguyen, Neona M. Lowe, Sophia Kellogg, Kuan‐Wei Huang, Hannah O'Toole, Elizabeth J. Hale, Venktesh S. Shirure, Bhupinder S. Shergill, Steven C. George, Randy P. Carney   +9 more
wiley   +1 more source

In vivoactivities of mutants of vascular endothelial growth factor (VEGF) with differentialin vitroactivities [PDF]

, 2000
William P. J. Leenders, Margarethe van Altena, Nicolette H. Lubsen, Dirk J. Ruiter, Robert de Waal   +4 more
openalex   +1 more source

Tissue-selective controlled decorin gene delivery in the rabbit cornea significantly retards corneal angiogenesis in vivo [abstract] [PDF]

, 2010
Recent studies have shown that decorin gene therapy inhibits neovascularization in many non-ocular tissues. We tested the efficacy of decorin gene delivery into stroma with AAV5 to impede vascular endothelial growth factor (VEGF)-induced angiogenesis in ...
Cowden, John W., Gupta, Rangan, 1978-, Schultz, Gregory, Sharma, Ajay, Tandon, Ashish, Tovey, Jonathan   +5 more
core  

Airborne 1O2 Delivery via a Superhydrophobic Dressing as a Pathway to Next‐Generation Wound Therapies, an in Vivo Murine Burn Model Study

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the SH bandage placed on an infected burn wound and its role in wound healing. A superhydrophobic PDMS membrane coated with the PS verteporfin is placed over the wound area and illuminated with a red laser at 690 nm, generating airborne 1O2 above the tissue.
Fernanda Viana Cabral, QianFeng Xu, Natalie Eidenschink, Pareesha Haresh, Alessandra Nara de Souza Rastelli, Jeremy Goverman, Alexander Greer, Alan M. Lyons, Tayyaba Hasan   +8 more
wiley   +1 more source

IL-17 induces reactive astrocytes and up-regulation of vascular endothelial growth factor (VEGF) through JAK/STAT signaling [PDF]

, 2017
Tao You, Yihui Bi, Jun Li, Mingkai Zhang, Xuezhou Chen, Keke Zhang, Jun Li   +6 more
openalex   +1 more source

A Mathematical Model for Lymphangiogenesis in Normal and Diabetic Wounds

, 2015
Several studies suggest that one possible cause of impaired wound healing is failed or insufficient lymphangiogenesis, that is the formation of new lymphatic capillaries.
Bianchi, Arianna, Painter, Kevin J., Sherratt, Jonathan A.   +2 more
core   +1 more source

Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy

Advanced Healthcare Materials, EarlyView.
This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su, Zihao He, Qianqian Chen, Long Chen, Caiyi Wei, Zijin Zhou, Jianhao Lin, Hui Li, Dan Xing   +8 more
wiley   +1 more source

Annexin-1-mediated Endothelial Cell Migration and Angiogenesis Are Regulated by Vascular Endothelial Growth Factor (VEGF)-induced Inhibition of miR-196a Expression [PDF]

, 2012
Anne-Laure Pin, François Houle, Patrick Fournier, Maëva Guillonneau, Éric R. Paquet, Martin J. Simard, Isabelle Royal, Jacques Huot   +7 more
openalex   +1 more source