Results 151 to 160 of about 364,472 (353)

Cellular Snowballing: Cell Adhesion and Migration Drive the Self‐Assembly of Cell‐Microgel Biohybrid Spheroids

Advanced Science, EarlyView.
A new class of biohybrid spheroids is engineered through the self‐assembly of adherent cells and extracellular matrix‐mimetic hydrogel microparticles (microgels). By mimicking a snowballing effect, this approach enables scalable formation of porous, millimeter‐scale spheroids with enhanced cell viability and molecular diffusion.
Zaman Ataie, Sina Kheirabadi, Changhao Li, Aneesh Risbud, Aswathy Sebastian, Istvan Albert, Sulin Zhang, Amir Sheikhi   +7 more
wiley   +1 more source

Engineering vascularised tissues in vitro [PDF]

, 2008
Tissue engineering aims at replacing or regenerating tissues lost due to diseases or traumas (Langer and Vacanti, 1993). However, mimicking in vitro the physiological complexity of vascularized tissue is a major obstacle, which possibly contributes to ...
de Boer, Jan, Liu, J., Rivron, N.C., Rivron, N.C., Rouwkema, Jeroen, van Blitterswijk, Clemens   +5 more
core   +3 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Relationship between Macular Thickness and the Ratio of Vascular Endothelial Growth Factor to Its Soluble Receptor 1 in Non-Proliferative Diabetic Retinopathy

مجله دانشکده پزشکی اصفهان, 2012
Background: The goal of this study was to determine the ratio of vascular endothelial growth factor (VEGF) to soluble VEGF receptor 1 (SVEGFR1) in aqueous humor of patients with non-proliferative diabetic retinopathy (NPDR).
Zahra Hasanpour, Shaghayegh Haghjooy Javanmard, Zahra Abbaspoor, Gholam Ali Naderian, Mehdi Jahanmard   +4 more
doaj  

A possible linkage between cholinergic and vascular endothelial growth factor (VEGF) systems in antidementia effects of traditional Chinese and Kampo medicines

, 2018
Kinzo Matsumoto, Hironori Fujiwara, Sachie Sasaki‐Hamada, Jun‐Ichiro Oka   +3 more
openalex   +2 more sources

Vascular endothelial growth factor (VEGF) fails to improve blood flow and to promote collateralization in a diabetic mouse ischemic hindlimb model [PDF]

, 2003
Ariel Roguin, Samy Nitecki, Irit Rubinstein, Eviatar Nevo, Aaron Avivi, Nina S. Levy, Zaid Abassi, Edmond Sabo, Orit Lache, Meira Frank, Aaron Hoffman, Andrew P. Levy   +11 more
openalex   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

The importance of vascular endothelial growth factor and polymorphism of the VEGF a gene (g634c) in the development of steatosis, fibrosis and cirrhosis of the liver patients in the city of Perm

, 2023
И. А. Булатова, Т. P. Shevlyukovа, А. П. Щекотова, С. В. Падучева   +3 more
openalex   +2 more sources

Size‐Modulated Mesoderm‐Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids

Advanced Science, EarlyView.
Micropatterned cardioids, CRISPR‐engineered reporter hiPSCs, deep‐tissue imaging, and single‐cell RNA sequencing are integrated to model mesoderm‐endoderm co‐development. Heart‐foregut crosstalk promotes single large cavitation inside cardioids, resembling early heart chamber formation. ABSTRACT The human heart, originating from the splanchnic mesoderm,
Plansky Hoang, David W. McKellar, Andrew Kowalczewski, Nhu Y. Mai, Meng Chai, Xiaojun L. Lian, Yi Zheng, Jeffrey Amack, Nathan Tucker, Iwijn De Vlaminck, Huaxiao Yang, Benjamin D. Cosgrove, Zhen Ma   +12 more
wiley   +1 more source

Sphingomonas paucimobilis‐Driven Epithelial–Endothelial Transition in Adenomyosis Pathogenesis

Advanced Science, EarlyView.
This study identifies epithelial–endothelial transition (EET) as a novel adenomyosis pathogenic mechanism driven by Sphingomonas paucimobilis colonization. Systematic inhibitor experiments validate a TNFα→NF‐κB→MMP signaling cascade essential for EET. Critically, bacterial culture supernatant fails to induce pathological changes, demonstrating viable ...
Peigen Chen, Hao Shi, Junxian He, Ziyu Liu, Yuanyuan Zhu, Xiaoyan Liang, Guihua Liu, Xing Yang   +7 more
wiley   +1 more source