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The Role of Vascular Endothelial Growth Factor (VEGF) in Renal Pathophysiology [PDF]
Kidney International, 2004 Vascular endothelial growth factor (VEGF) is an endothelial-specific growth factor that promotes endothelial cell proliferation, differentiation and survival, mediates endothelium-dependent vasodilatation, induces microvascular hyperpermeability and participates in interstitial matrix remodeling.
An S De Vriese +2 more
exaly +5 more sources
VEGF (Vascular Endothelial Growth Factor) and Fibrotic Lung Disease [PDF]
International Journal of Molecular Sciences, 2018 Interstitial lung disease (ILD) encompasses a group of heterogeneous diseases characterised by varying degrees of aberrant inflammation and fibrosis of the lung parenchyma. This may occur in isolation, such as in idiopathic pulmonary fibrosis (IPF) or as part of a wider disease process affecting multiple organs, such as in systemic sclerosis.
John D Pauling +2 more
exaly +4 more sources
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Vascular endothelial growth factor (VEGF) and its receptors
The FASEB Journal, 1999ABSTRACT Vascular endothelial growth factor (VEGF) is a highly specific mitogen for vascular endothelial cells. Five VEGF isoforms are generated as a result of alternative splicing from a single VEGF gene. These isoforms differ in their molecular mass and in biological properties such as their ability to bind to ...
G, Neufeld +3 more
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Vascular Endothelial Growth Factor (VEGF) in Autoimmune Diseases
Journal of Clinical Immunology, 2007Vascular endothelial growth factor (VEGF) is a potent stimulating factor for angiogenesis and vascular permeability. There are eight isoforms with different and sometimes overlapping functions. The mechanisms of action are under investigation with emerging insights into overlapping pathways and cross-talk between other receptors such as the neuropilins,
Jozélio Freire, Carvalho +2 more
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Vascular Endothelial Growth Factor (VEGF)
1995Abstract VEGF purified from conditioned media of normal and neoplastic cells is a glycoprotein of -45000 kDa (Ferrara and Henzel 1989). It is inactivated by reducing agents but it is heat- and acid-stable. By alternative splicing of RNA, VEGF may exist in four different homodimeric isoforms (Leung et al. 1989; Houck et al.
N Ferrara, J E Park
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Vascular Endothelial Growth Factor (VEGF) Inhibition - A Critical Review
Anti-Cancer Agents in Medicinal Chemistry, 2007Angiogenesis, or formation of new blood capillaries from preexisting vessels, plays both beneficial and damaging roles in the organism. It is a result of a complex balance of positive and negative regulators, and vascular endothelial growth factor (VEGF) is one of the most important pro-angiogenic factors involved in tumor angiogenesis.
Irina Sousa, Moreira +2 more
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Vascular Endothelial Growth Factor (VEGF) Receptors
1995Abstract Two tyrosine kinases have been recently identified as putative VEGF receptors (deVries et al. 1992; Terman et al. 1992a). The flt-1 (fms-like-tyrosine kinase; Shibuya et al. 1990) and KOR (kinase domain region; Terman et al. 1991) proteins have been shown to bind VEGF with high affinity.
J E Park, N Ferrara
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Vascular endothelial growth factors (VEGF): role in pathological processes
Vestnik oftal'mologii, 2016Russian and foreign literature sources on vascular endothelial growth factors (VEGF) from different parts of the human body, their prevalence and involvement in pathological processes were analyzed. A conclusion has been drawn that further research on different types of VEGF is needed.
Yu A, Borzilova +2 more
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Expression of Vascular Endothelial Growth Factor (VEGF) and VEGF Receptors in Human Neuroblastomas
Medical and Pediatric Oncology, 2000Vascular endothelial growth factor (VEGF) is a specific endothelial cell mitogen that stimulates angiogenesis and plays a crucial role in tumor growth. The aim of the present study was to evaluate the expression of VEGF and of its two high-affinity tyrosine kinase receptors (KDR and Flt-1) in neuroblastoma surgical samples and cell lines.The VEGF, KDR,
Jason Perret +2 more
exaly +4 more sources
On the detection of neutrophil-derived vascular endothelial growth factor (VEGF)
Journal of Immunological Methods, 1999In recent years, several investigators have addressed the question of whether mature polymorphonuclear neutrophils (PMN) are able to secrete cytokines. Their studies have brought forward new and exciting discoveries, by establishing that the release of inflammatory cytokines constitutes a novel and important aspect of the neutrophil biology, thereby ...
SCAPINI, Patrizia +2 more
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