Results 31 to 40 of about 236,813 (316)

Syndecan-1 regulates vascular smooth muscle cell phenotype.

PLoS ONE, 2014
ObjectiveWe examined the role of syndecan-1 in modulating the phenotype of vascular smooth muscle cells in the context of endogenous inflammatory factors and altered microenvironments that occur in disease or injury-induced vascular remodeling.Methods ...
Somali Chaterji, Christoffer H Lam, Derek S Ho, Daniel C Proske, Aaron B Baker   +4 more
doaj   +1 more source

Vascular Smooth Muscle Cell Development and Cardiovascular Malformations

Cardiology Discovery, 2021
. Vascular smooth muscle cells (VSMCs) have diverse biological functions that include maintaining the vascular structure and recruiting progenitors to form the embryonic vascular system.
Lihua Qi, Wei Kong, Yi Fu, Xiaoxia Fu, Tianyu Xu   +4 more
doaj   +1 more source

Regulation of Pulmonary Vascular Smooth Muscle Contractility in Pulmonary Arterial Hypertension: Implications for Therapy

Frontiers in Physiology, 2017
There are two primary components that produce pulmonary arterial hypertension (PAH); aberrant structural changes (smooth muscle cell proliferation, smooth muscle cell hypertrophy, and the deposition of matrix proteins within the media of pulmonary ...
Melissa A. Lyle, Jonathan P. Davis, Frank V. Brozovich   +2 more
doaj   +1 more source

Human Vascular Smooth Muscle Function and Oxidative Stress Induced by NADPH Oxidase with the Clinical Implications

Cells, 2021
Among reactive oxygen species, superoxide mediates the critical vascular redox signaling, resulting in the regulation of the human cardiovascular system.
Kazumi Takaishi, Hiroyuki Kinoshita, Shingo Kawashima, Shinji Kawahito   +3 more
doaj   +1 more source

Nuclear Smooth Muscle α-actin in Vascular Smooth Muscle Cell Differentiation

, 2023
Abstract Missense variants throughout ACTA2, encoding smooth muscle α-actin (αSMA), predispose to adult onset thoracic aortic disease, but variants disrupting arginine 179 (R179) lead to Smooth Muscle Dysfunction Syndrome (SMDS) characterized by childhood-onset diverse vascular diseases.
Callie Kwartler, Albert Pedroza, Anita Kaw, Pujun Guan, Shuangtao Ma, Xue-yan Duan, Caroline Kernell, Charis Wang, Jose Esparza Pinelo, Mikayla Borthwick, Jiyuan Chen, Yuan Zhong, Sanjay Sinha, Xuetong Shen, Michael Fischbein, Dianna Milewicz   +15 more
openaire   +2 more sources

Vascular smooth muscle cell senescence in atherosclerosis [PDF]

Cardiovascular Research, 2006
Markers of cell senescence have been identified in both the blood and vessel wall of patients with atherosclerosis. In particular, vascular smooth muscle cells (VSMCs) derived from human plaques show numerous features of senescence both in culture and in vivo.
Isabelle, Gorenne, Mary, Kavurma, Stephen, Scott, Martin, Bennett   +3 more
openaire   +2 more sources

Vascular smooth muscle cells

, 2017
Abstract To understand the function of arteries in the regulation of blood supply throughout the body it is essential to realize that the vessel wall is composed predominantly of smooth muscle cells (SMCs) with only one single layer of luminal endothelial cells.
Bochaton-Piallat, Marie-Luce, de Vries, Carlie JM, van Eys, Guillaume J   +2 more
openaire   +2 more sources

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Vascular Smooth Muscle Cell Proliferation in Restenosis [PDF]

Circulation: Cardiovascular Interventions, 2011
Current therapeutic approaches to restore blood flow in stenotic blood vessels involve the use of percutaneous devices and coronary bypass surgery. In all procedures that disrupt the normal integrity of the blood vessels, there is an increased incidence of vessel luminal narrowing, termed restenosis.
Steven O, Marx, Hana, Totary-Jain, Andrew R, Marks   +2 more
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source