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Vascular smooth muscle cell differentiation – 2010 [PDF]
Journal of Biomedical Research, 2010 Vascular smooth muscle cells have attracted considerable interest as a model for a flexible program of gene expression. This cell type arises throughout the embryo body plan via poorly understood signaling cascades that direct the expression of transcription factors and microRNAs which, in turn, orchestrate the activation of contractile genes ...
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Redox Biology, 2022 Prevention of phenotype switching of vascular smooth muscle cells is an important determinant of normal vascular physiology. Hydrogen peroxide (H2O2) promotes osteogenic differentiation of vascular smooth muscle cells through expression of Runt related ...
Kai er Ying +7 more
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An essential requirement for β1 integrin in the assembly of extracellular matrix proteins within the vascular wall [PDF]
, 2012 β1 integrin has been shown to contribute to vascular smooth muscle cell differentiation, adhesion and mechanosensation in vitro. Here we showed that deletion of β1 integrin at the onset of smooth muscle differentiation resulted in interrupted aortic arch,
Fassler, Reinhard +6 more
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Stem cells, vascular smooth muscle cells and atherosclerosis.
Histology and histopathology, 2006 Stem cells have the ability to differentiate into a variety of cells to replace dead cells or to repair tissue. Recently, accumulating evidence indicates that mechanical forces, cytokines and other factors can influence stem cell differentiation into vascular smooth muscle cells (SMCs).
Margariti, A., Zeng, L., Xu, Q.
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Replication of smooth muscle cells in vascular disease. [PDF]
Circulation Research, 1986 Smooth muscle proliferation has been recognized as central to the pathology of both major forms of vascular disease: atherosclerosis and hypertension. Recent advances in our knowledge of mechanisms of control of proliferation suggest that events occurring in adult animals may recapitulate portions of the developmental biology of the smooth muscle cell.
Schwartz, SM, Campbell, GR, Campbell, JH
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Intimal smooth muscle cells are a source but not a sensor of anti-inflammatory CYP450 derived oxylipins [PDF]
, 2015 Vascular pathologies are associated with changes in the presence and expression of morphologically distinct vascular smooth muscle cells. In particular, in complex human vascular lesions and models of disease in pigs and rodents, an intimal smooth muscle
Arnold +46 more
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Vascular smooth muscle cell contractile function and mechanotransduction [PDF]
, 2018 Vascular smooth muscle cells (VSMCs) are the predominant cell type in the arterial wall and normally adopt a quiescent, contractile phenotype to regulate vascular tone.
Ahmed, Sultan, Warren, Derek T.
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Heliyon, 2023 Vascular smooth muscle cells (VSMCs) are primarily responsible for vasoconstriction and the regulation of blood pressure1. Pyroptosis, a particular form of regulated cell death, is involved in multiple vascular injuries, including hypertensive vascular ...
Zimin Fang +9 more
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Pulmonary Circulation, 2020 Platelet-derived growth factor is one of the major growth factors found in human and mammalian serum and tissues. Abnormal activation of platelet-derived growth factor signaling pathway through platelet-derived growth factor receptors may contribute to ...
Kang Wu +21 more
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Vascular smooth muscle cell senescence in atherosclerosis [PDF]
Cardiovascular Research, 2006 Markers of cell senescence have been identified in both the blood and vessel wall of patients with atherosclerosis. In particular, vascular smooth muscle cells (VSMCs) derived from human plaques show numerous features of senescence both in culture and in vivo.
Mary M. Kavurma +3 more
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