Results 71 to 80 of about 513,814 (378)
Uncertainty quantification of a three-dimensional in-stent restenosis model with surrogate modelling [PDF]
arXiv, 2021 In-Stent Restenosis is a recurrence of coronary artery narrowing due to vascular injury caused by balloon dilation and stent placement. It may lead to the relapse of angina symptoms or to an acute coronary syndrome. An uncertainty quantification of a model for In-Stent Restenosis with four uncertain parameters (endothelium regeneration time, the ...
arxiv
The Myogenic Response in Isolated Rat Cerebrovascular Arteries: Smooth Muscle Cell Model [PDF]
Medical Engineering & Physics, 25(8):691-709, 2003, 2013 Previous models of the cerebrovascular smooth muscle cell have not addressed the interaction between the electrical, chemical and mechanical components of cell function during the development of active tension. These models are primarily electrical, biochemical or mechanical in their orientation, and do not permit a full exploration of how the smooth ...
arxiv +1 more source
European Journal of Cardio-Thoracic Surgery, 2015 OBJECTIVES Brahma-related gene 1 (BRG1) and long non-coding RNAs (lncRNAs) play important roles in cellular processes. However, little is known regarding their roles in thoracic aortic aneurysms.
Shu-wei Wang +8 more
semanticscholar +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Blocking PERK resuces vascular smooth muscle cells from homocysteine-induced ER stress and apoptosis
Frontiers in Bioscience-Landmark, 2020 Hyperhomocysteinemia induces stress response in endoplasmic reticulum (ERS). Here, we tested whether blockage of homocysteine (Hcy) induced ERS and subsequent apoptosis in vascular smooth muscle cells can be inhibited by blockage of PERK/eIF2α/ATF4/CHOP ...
Wei Li +8 more
doaj +1 more source
Acute oxygen sensing by vascular smooth muscle cells
Frontiers in Physiology, 2023 An adequate supply of oxygen (O2) is essential for most life forms on earth, making the delivery of appropriate levels of O2 to tissues a fundamental physiological challenge.
Alejandro Moreno-Domínguez +12 more
doaj +1 more source
A control mechanism for intramural periarterial drainage via astrocytes: How neuronal activity could improve waste clearance from the brain [PDF]
, 2017 The mechanisms behind waste clearance from deep within the parenchyma of the brain remain unclear to this date. Experimental evidence has shown that one pathway for waste clearance, termed intramural periarterial drainage (IPAD), is the rapid drainage of interstitial fluid (ISF) via basement membranes (BM) of the smooth muscle cells (SMC) of cerebral ...
arxiv +1 more source
Patient-specific predictions of aneurysm growth and remodeling in the ascending thoracic aorta using the homogenized constrained mixture model [PDF]
Biomechanics and Modeling in Mechanobiology, Springer Verlag,
2019, 18 (6), pp.1895-1913, 2019 In its permanent quest of mechanobiological homeostasis, our vascula-ture significantly adapts across multiple length and time scales in various physiological and pathological conditions. Computational modeling of vascular growth and remodeling (G\&R) has significantly improved our insights of the mechanobio-logical processes of diseases such as ...
arxiv +1 more source
The journals of gerontology. Series A, Biological sciences and medical sciences, 2015 Arterial aging is a major risk factor for the occurrence of cardiovascular diseases. The aged artery is characterized by endothelial dysfunction and vascular smooth muscle cells altered physiology together with low-grade chronic inflammation.
Ileana Badi +7 more
semanticscholar +1 more source
Vascular Smooth Muscle Cell Proliferation in Restenosis [PDF]
Circulation: Cardiovascular Interventions, 2011 Current therapeutic approaches to restore blood flow in stenotic blood vessels involve the use of percutaneous devices and coronary bypass surgery. In all procedures that disrupt the normal integrity of the blood vessels, there is an increased incidence of vessel luminal narrowing, termed restenosis.
Steven O. Marx +2 more
openaire +2 more sources