Results 71 to 80 of about 397,979 (354)

Research advances on the role of Runx2-related miRNAs in vascular calcification of chronic kidney disease

Linchuang shenzangbing zazhi, 2022
Vascular calcification （VC） is a major cause of cardiovascular mortality in patients with chronic kidney disease （CKD）. Current studies suggest that VC of CKD is not simply an ectopic deposition of calcium phosphate crystals in vascular wall.
Lu Yang-yang, Bai Ya-ling, Xu Jin-sheng
doaj  

Acute oxygen sensing by vascular smooth muscle cells

Frontiers in Physiology, 2023
An adequate supply of oxygen (O2) is essential for most life forms on earth, making the delivery of appropriate levels of O2 to tissues a fundamental physiological challenge.
Alejandro Moreno-Domínguez, Alejandro Moreno-Domínguez, Alejandro Moreno-Domínguez, Olaia Colinas, Olaia Colinas, Olaia Colinas, Tarik Smani, Tarik Smani, Juan Ureña, Juan Ureña, José López-Barneo, José López-Barneo, José López-Barneo   +12 more
doaj   +1 more source

Fibrinogen is chemotactic for vascular smooth muscle cells

FEBS Letters, 1989
We studied the effect of fibrinogen on the migration of bovine aortic smooth muscle cells in culture, using a Neuro Probe 48‐well micro chemotaxis chamber. Fibrinogen stimulated the migration of the cells dose‐dependently at concentrations from 30 to 1OOO μg/ml.
Fumio Kuzuya, Kanichi Asai, Michitaka Naito, Toshio Hayashi, Masafumi Kuzuya, Chiaki Funaki   +5 more
openaire   +3 more sources

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

RNF213 and GUCY1A3 in Moyamoya Disease: Key Regulators of Metabolism, Inflammation, and Vascular Stability

Frontiers in Neurology, 2021
Moyamoya disease is an idiopathic chronically progressive cerebrovascular disease, which causes both ischemic and hemorrhagic stroke. Genetic studies identified RNF213/Mysterin and GUCY1A3 as disease-causing genes.
Yohei Mineharu, Susumu Miyamoto
doaj   +1 more source

Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells

Nature Cell Biology, 2015
The use of human pluripotent stem cells for in vitro disease modelling and clinical applications requires protocols that convert these cells into relevant adult cell types. Here, we report the rapid and efficient differentiation of human pluripotent stem
Christoph Patsch, Ludivine Challet-Meylan, E. Thoma, E. Urich, Tobias Heckel, J. O’Sullivan, Stephanie Grainger, Friedrich G. Kapp, Lin Sun, K. Christensen, Yulei Xia, Mary H. C. Florido, Wei He, W. Pan, M. Prummer, C. Warren, R. Jakob‐Roetne, U. Certa, R. Jagasia, P. Freskgård, Isaac Adatto, D. Kling, P. Huang, L. Zon, E. Chaikof, Robert E. Gerszten, M. Graf, R. Iacone, Chad A. Cowan   +28 more
semanticscholar   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Dietary salt initiates redox signaling between endothelium and vascular smooth muscle through NADPH oxidase 4

Redox Biology, 2022
Prevention of phenotype switching of vascular smooth muscle cells is an important determinant of normal vascular physiology. Hydrogen peroxide (H2O2) promotes osteogenic differentiation of vascular smooth muscle cells through expression of Runt related ...
Kai er Ying, Wenguang Feng, Wei-Zhong Ying, Xingsheng Li, Dongqi Xing, Yong Sun, Yabing Chen, Paul W. Sanders   +7 more
doaj  

Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD.

Journal of the American Society of Nephrology, 2004
Patients with ESRD have a high circulating calcium (Ca) x phosphate (P) product and develop extensive vascular calcification that may contribute to their high cardiovascular morbidity. However, the cellular mechanisms underlying vascular calcification in
J. Reynolds, A. Joannides, J. Skepper, R. McNair, L. Schurgers, D. Proudfoot, W. Jahnen-Dechent, P. Weissberg, C. Shanahan   +8 more
semanticscholar   +1 more source

Modelling Atherosclerotic Plaque Cap Mechanics: Microcalcifications Reduce Mechanical Properties in Mesenchymal Stromal Cell‐Based Model

Advanced Biology, EarlyView.
This study develops a tissue‐engineered model of the atherosclerotic cap using human mesenchymal stromal cells (MSCs). After 2 weeks of culture to produce a collagenous matrix, a mineralizing medium induces microcalcifications over 4 weeks. These constructs, imaged with second harmonic generation microscopy, lead to reduced ultimate stress at rupture ...
Imke L. Jansen, Deniz Şahin, Frank J.H. Gijsen, Eric Farrell, Kim van der Heiden   +4 more
wiley   +1 more source