Results 31 to 40 of about 1,799,199 (341)

The effect of uric acid-lowering therapy on vascular stiffness in patients with gout [PDF]

Journal of Medicine and Life Science
Several studies have reported that vascular stiffness and risk of cardiovascular disease increase in patients with gout. Although it has been reported that uric acid-lowering treatment improves vascular stiffness in several patient groups, it remains ...
Wooseong Jeong, Jinseok Kim
doaj   +1 more source

Protective role of CXCR7 activation in neonatal hyperoxia-induced systemic vascular remodeling and cardiovascular dysfunction in juvenile rats

Scientific Reports, 2023
Neonatal hyperoxia induces long-term systemic vascular stiffness and cardiovascular remodeling, but the mechanisms are unclear. Chemokine receptor 7 (CXCR7) represents a key regulator of vascular homeostasis and repair by modulating TGF-β1 signaling ...
Merline Benny, Mayank Sharma, Shathiyah Kulandavelu, PingPing Chen, Runxia Tian, Sydne Ballengee, Jiang Huang, Amanda F. Levine, Matteo Claure, Augusto F. Schmidt, Roberto I. Vazquez-Padron, Claudia O. Rodrigues, Shu Wu, Omaida C. Velazquez, Karen C. Young   +14 more
doaj   +1 more source

Arterial stiffness in aortic stenosis - complex clinical and prognostic implications

Biomedical Papers, 2022
Arterial stiffness and degenerative aortic stenosis (AoS) are frequently associated leading to a combined valvular and vascular load imposed on the left ventricle (LV).
Adriana Albu, Ioana Para, Cristina Bidian   +2 more
doaj   +1 more source

Vascular Stiffness in Children With Chronic Kidney Disease [PDF]

Hypertension, 2017
Carotid-femoral pulse wave velocity (cfPWV) is a measure of arterial stiffness associated with cardiovascular events in the general population and in adults with chronic kidney disease. However, few data exist regarding cfPWV in children with chronic kidney disease.
Jonathan D. Savant, A. Betoko, K. Meyers, M. Mitsnefes, J. Flynn, R. Townsend, L. Greenbaum, A. Dart, B. Warady, S. Furth   +9 more
semanticscholar   +3 more sources

Smooth Muscle Cell Stiffness Syndrome – Revisiting the Structural Basis of Arterial Stiffness

Frontiers in Physiology, 2015
In recent decades, the pervasiveness of increased arterial stiffness in patients with cardiovascular disease has become increasingly apparent. Though this phenomenon has been well documented in humans and animal models of disease for well over a century,
Nancy L. Sehgel, Nancy L. Sehgel, Stephen F. Vatner, Gerald A Meininger   +3 more
doaj   +1 more source

RhoBTB1 reverses established arterial stiffness in angiotensin II–induced hypertension by promoting actin depolymerization

JCI Insight, 2022
Arterial stiffness predicts cardiovascular disease and all-cause mortality, but its treatment remains challenging. Mice treated with angiotensin II (Ang II) develop hypertension, arterial stiffness, vascular dysfunction, and a downregulation of Rho ...
Shi Fang, Jing Wu, John J. Reho, Ko-Ting Lu, Daniel T. Brozoski, Gaurav Kumar, Alec M. Werthman, Sebastiao Donato Silva Jr., Patricia C. Muskus Veitia, Kelsey K. Wackman, Angela J. Mathison, Bi Qing Teng, Chien-Wei Lin, Frederick W. Quelle, Curt D. Sigmund   +14 more
doaj   +1 more source

The focal adhesion: a regulated component of aortic stiffness. [PDF]

PLoS ONE, 2013
Increased aortic stiffness is an acknowledged predictor and cause of cardiovascular disease. The sources and mechanisms of vascular stiffness are not well understood, although the extracellular matrix (ECM) has been assumed to be a major component.
Robert J Saphirstein, Yuan Z Gao, Mikkel H Jensen, Cynthia M Gallant, Susanne Vetterkind, Jeffrey R Moore, Kathleen G Morgan   +6 more
doaj   +1 more source

Adipokines and Arterial Stiffness in Obesity

Medicina, 2021
Adipokines are active molecules with pleiotropic effects produced by adipose tissue and involved in obesity-related metabolic and cardiovascular diseases. Arterial stiffness, which is a consequence of arteriosclerosis, has been shown to be an independent
Ioana Para, Adriana Albu, Mihai D. Porojan   +2 more
doaj   +1 more source

Vitamin K Supplementation to Improve Vascular Stiffness in CKD: The K4Kidneys Randomized Controlled Trial.

Journal of the American Society of Nephrology, 2020
BACKGROUND Vascular calcification, a risk factor for cardiovascular disease, is common among patients with CKD and is an independent contributor to increased vascular stiffness and vascular risk in this patient group. Vitamin K is a cofactor for proteins
Miles D. Witham, J. Lees, Myra White, Margaret M Band, Samira Bell, D. Chantler, Ian Ford, Roberta L. Fulton, Gwen Kennedy, Roberta Littleford, Ian V McCrea, D. McGlynn, M. Panarelli, M. Ralston, E. Rutherford, Alison Severn, Nicola Thomson, J. Traynor, A. D. Struthers, K. Wetherall, Patrick B. Mark   +20 more
semanticscholar   +1 more source

Restoring Blood Pressure in Hypertensive Mice Fails to Fully Reverse Vascular Stiffness

Frontiers in Physiology, 2020
Background Hypertension is a well-established driver of vascular remodeling and stiffening. The goal of this study was to evaluate whether restoring normal blood pressure (BP) fully restores vascular stiffness toward that of normotensive controls ...
J. Steppan, Sandeep Jandu, William Savage, Huilei Wang, Sara Kang, Roshini Narayanan, D. Nyhan, L. Santhanam   +7 more
semanticscholar   +1 more source