Results 31 to 40 of about 202,203 (296)

Smooth Muscle Cell Stiffness Syndrome – Revisiting the Structural Basis of Arterial Stiffness

Frontiers in Physiology, 2015
In recent decades, the pervasiveness of increased arterial stiffness in patients with cardiovascular disease has become increasingly apparent. Though this phenomenon has been well documented in humans and animal models of disease for well over a century,
Nancy L. Sehgel, Nancy L. Sehgel, Stephen F. Vatner, Gerald A Meininger   +3 more
doaj   +1 more source

Inhibition of the histone methyltransferase EZH2 induces vascular stiffness. [PDF]

Clin Sci (Lond)
Abstract Vascular stiffness increases with aging, obesity and hypertension and predicts cardiovascular risk. The levels of histone H3-lysine-27 methylation (H3K27me) and the histone methyltransferase EZH2 both decrease in aging vessels, driving vascular stiffness. The impact of EZH2 inhibitors on vascular stiffness is unknown.
Ibarrola J, Xiang RR, Sun Z, Lu Q, Hill MA, Jaffe IZ.   +5 more
europepmc   +3 more sources

Substrate stiffness and VE-cadherin mechano-transduction coordinate to regulate endothelial monolayer integrity. [PDF]

, 2017
The vascular endothelium is subject to diverse mechanical cues that regulate vascular endothelial barrier function. In addition to rigidity sensing through integrin adhesions, mechanical perturbations such as changes in fluid shear stress can also ...
Andresen Eguiluz, Roberto C, Kaylan, Kerim B, Leckband, Deborah E, Underhill, Gregory H   +3 more
core   +1 more source

Alterations in vascular function in primary aldosteronism - a cardiovascular magnetic resonance imaging study [PDF]

, 2014
Introduction: Excess aldosterone is associated with increased cardiovascular risk. Aldosterone has a permissive effect on vascular fibrosis. Cardiovascular magnetic resonance imaging (CMR) allows study of vascular function by measuring aortic ...
A McCurley, A Rudolph, A Tomaschitz, B Fink, B Strauch, B Strauch, C Catena, C Delles, C Delles, CB Stehr, D Rizzoni, DA Calhoun, E M Freel, E P McQuarrie, EM Freel, G Bernini, GE Callera, GF Mitchell, GP Rossi, JM Connell, JW Funder, K Gaddam, L U Zimmerli, LU Zimmerli, MJ van Trijp, MR Robinson, NC Edwards, OJ Rider, OJ Rider, P B Mark, P Milliez, P Rerkpattanapipat, PB Mark, R Holaj, R Rocha, RB Stacey, S Boyle, S Laurent, T Indra, WJ Rogers, YH Lin   +40 more
core   +1 more source

RhoBTB1 reverses established arterial stiffness in angiotensin II–induced hypertension by promoting actin depolymerization

JCI Insight, 2022
Arterial stiffness predicts cardiovascular disease and all-cause mortality, but its treatment remains challenging. Mice treated with angiotensin II (Ang II) develop hypertension, arterial stiffness, vascular dysfunction, and a downregulation of Rho ...
Shi Fang, Jing Wu, John J. Reho, Ko-Ting Lu, Daniel T. Brozoski, Gaurav Kumar, Alec M. Werthman, Sebastiao Donato Silva Jr., Patricia C. Muskus Veitia, Kelsey K. Wackman, Angela J. Mathison, Bi Qing Teng, Chien-Wei Lin, Frederick W. Quelle, Curt D. Sigmund   +14 more
doaj   +1 more source

Adipokines and Arterial Stiffness in Obesity

Medicina, 2021
Adipokines are active molecules with pleiotropic effects produced by adipose tissue and involved in obesity-related metabolic and cardiovascular diseases. Arterial stiffness, which is a consequence of arteriosclerosis, has been shown to be an independent
Ioana Para, Adriana Albu, Mihai D. Porojan   +2 more
doaj   +1 more source

TRPV4-A Missing Link Between Mechanosensation and Immunity [PDF]

, 2020
Transient receptor potential vanilloid-type 4 (TRPV4) cation channel is widely expressed in all tissues as well as in immune cells and its function as mechanosensitive Ca2+ channel seems to be conserved throughout all mammalian species. Of late, emerging
Kuebler, Wolfgang M., Michalick, Laura
core   +1 more source

The focal adhesion: a regulated component of aortic stiffness. [PDF]

PLoS ONE, 2013
Increased aortic stiffness is an acknowledged predictor and cause of cardiovascular disease. The sources and mechanisms of vascular stiffness are not well understood, although the extracellular matrix (ECM) has been assumed to be a major component.
Robert J Saphirstein, Yuan Z Gao, Mikkel H Jensen, Cynthia M Gallant, Susanne Vetterkind, Jeffrey R Moore, Kathleen G Morgan   +6 more
doaj   +1 more source

Comparison of the novel START vascular stiffness index with the CAVI index, assessment of their values and correlations with clinical parameters

Российский кардиологический журнал, 2023
Aim. To compare the cardio-ankle vascular index (CAVI) and the novel START vascular stiffness index and assess their values and correlations with clinical parameters.Material and methods.
I. A. Vasyutin, K. Leon, T. A. Safronova, I. B. Bakholdin, V. S. Barkan, V. A. Milyagin, T. P. Pronko, A. V. Talov, D. E. Tentyukov, V. S. Chulkov, K. V. Peskov, V. I. Podzolkov, V. V. Sokolov   +12 more
doaj   +1 more source

The acute effect of maximal exercise on central and peripheral arterial stiffness indices and hemodynamics in children and adults [PDF]

, 2016
Xavier Melo is supported by a research grant from the Foundation for Science and Technology (FCT), Ministry of Education and Science of Portugal (grant: SFRH/ BD/ 70515/ 2010). Nuno M.
Fernhall, Bo, Melo, Xavier, Pimenta, Nuno, Pinto, Rita, Santa-Clara, Helena, Santos, Diana, Sardinha, Luis   +6 more
core   +1 more source