Results 61 to 70 of about 4,131 (170)

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

Advanced Materials Technologies, Volume 11, Issue 9, 6 May 2026.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang, He Huang, Hongliang Dong, Qiang Ma, Hongyan Jin   +4 more
wiley   +1 more source

Evidence of Vasculogenic Mimicry in a Palpebral Melanocytoma in a Dog [PDF]

Journal of Comparative Pathology, 2018
A 7-year-old neutered female Doberman pinscher was presented with a palpebral nodule on the haired eyelid of the left eye. The nodule was removed surgically. Microscopically, the nodule was consistent with eyelid melanocytoma. The tumour was characterized by the presence of numerous lacunar and slit-like spaces filled by erythrocytes and interspersed ...
Laura Nordio, Sabina Fattori, Marta Vascellari, Chiara Giudice   +3 more
openaire   +3 more sources

Sphingomonas paucimobilis‐Driven Epithelial–Endothelial Transition in Adenomyosis Pathogenesis

Advanced Science, Volume 13, Issue 29, 22 May 2026.
This study identifies epithelial–endothelial transition (EET) as a novel adenomyosis pathogenic mechanism driven by Sphingomonas paucimobilis colonization. Systematic inhibitor experiments validate a TNFα→NF‐κB→MMP signaling cascade essential for EET. Critically, bacterial culture supernatant fails to induce pathological changes, demonstrating viable ...
Peigen Chen, Hao Shi, Junxian He, Ziyu Liu, Yuanyuan Zhu, Xiaoyan Liang, Guihua Liu, Xing Yang   +7 more
wiley   +1 more source

Thalidomide influences growth and vasculogenic mimicry channel formation in melanoma

Journal of Experimental & Clinical Cancer Research, 2008
Aims To observe the effects of thalidomide on melanoma tumor growth and blood supply patterns in C57 mice. Methods Thirty mice inoculated subcutaneously with B16F10 cells were randomly divided into the treatment group and the control group.
Liu Zhiyong, Gu Yanjun, Li Man, Zhang Shiwu, Xu Shaoyan, Cui Yanfeng, Sun Baocun   +6 more
doaj   +1 more source

Tumor Anti‐Angiogenesis Therapy and Its Influence on Immune Cell Function in the Tumor Microenvironment

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Vascular normalization, one promising anti‐angiogenic strategy, has the potential to enhance vascular perfusion and elevate the infiltration of immune cells into tumors by rectifying aberrant tumor blood vessels. This results in the enhancement of immunotherapy.
Yu Tang, Yuyan Ding, LiPing Wang, Yujiao Yang, Youwei Han, Peng Zhou, Huiheng Qu, Kaiyuan Deng, Jiazeng Xia   +8 more
wiley   +1 more source

Regulation Networks Driving Vasculogenic Mimicry in Solid Tumors

Frontiers in Oncology, 2020
Vasculogenic mimicry (VM) is a mechanism whereby cancer cells form microvascular structures similar to three-dimensional channels to provide nutrients and oxygen to tumors.
Olga N. Hernández de la Cruz, José Sullivan López-González, Raúl García-Vázquez, Yarely M. Salinas-Vera, Marcos A. Muñiz-Lino, Dolores Aguilar-Cazares, César López-Camarillo, Ángeles Carlos-Reyes   +7 more
doaj   +1 more source

The Fidelity Paradox in Spinal Cord Injury: Reframing Biomechanical Mimicry and Neurobiological Relevance for Clinical Translation

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
The manuscript attributes translational failure in spinal cord injury to a fidelity paradox: prioritizing biomechanical mimicry over biological equivalence. To bridge this gap, we introduce the mechanistic fidelity matching (MFM) framework. MFM shifts the paradigm from indiscriminate single‐model reliance to selecting species based on their specific ...
Liang Cao, Wenjun Pi, Yanjun Zhang, V. Wee Yong, Mengzhou Xue   +4 more
wiley   +1 more source

Mitochondrial DNA depletion promotes vasculogenic properties through mesenchymal alteration in glioblastoma

Journal of Taibah University for Science
Glioblastoma, the most aggressive brain tumour with high and heterogenic vascularity, frequently courses with mtDNA depletion. However, the effects of mtDNA depletion on mesenchymal characteristics responsible for aggressiveness and vasculogenic mimicry ...
Özlem Türksoy Terzioğlu, Gökhan Terzioğlu, Ömer Faruk Bayrak   +2 more
doaj   +1 more source

Cancer‐Associated Fibroblasts Functions as Multifunctional Architects of the Tumor Stroma and Represent Emerging Therapeutic Vulnerabilities

Advanced Science, Volume 13, Issue 24, 27 April 2026.
ABSTRACT Cancer‐associated fibroblasts (CAFs) are the predominant stromal components within the tumor microenvironment (TME), playing multifaceted roles in cancer progression through dynamic interactions with neoplastic and immune cells. Emerging evidence has revealed remarkable heterogeneity and plasticity of CAFs, which originate from diverse ...
Rujiao Liu, Lili Su, Shuiping Gao, Wenting Liu, Hongxia Wang   +4 more
wiley   +1 more source

Kaempferol Promotes Apoptosis While Inhibiting Cell Proliferation via Androgen-Dependent Pathway and Suppressing Vasculogenic Mimicry and Invasion in Prostate Cancer

Analytical Cellular Pathology, 2019
Kaempferol is a well-known natural flavonol reported to be a potential treatment for multiple cancers. In this study, we demonstrated that cell growth of androgen-sensitive LNCaP cells could be inhibited 33% by 5 μM kaempferol, around 60% by 10 μM ...
Jun Da, Mingxi Xu, Yiwei Wang, Wenfeng Li, Mujun Lu, Zhong Wang   +5 more
doaj   +1 more source