Results 51 to 60 of about 4,131 (170)
Tumors have high requirements in terms of nutrients and oxygen. Angiogenesis is the classical mechanism for vessel formation. Tumoral vascularization has the function of nourishing the cancer cells to support tumor growth.
Martha Resendiz-Hernández +10 more
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Mig-7 Linked to Vasculogenic Mimicry [PDF]
Solid tumor development consists of a series of stages during which cells undergo genetic and phenotypic alterations that allow cancer cells to evade normal regulation and to finally colonize distant sites in the body. In this issue of The American Journal of Pathology, Petty et al report that expression of a relatively understudied protein called ...
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Vitamins could regulate both MMP‐2 and MMP‐9 expression and activity through transcriptional and MAPK signaling pathway modulation. This study highlights the potential of vitamins as low‐toxicity therapeutic or adjunct agents for targeting MMP‐mediated cancer progression. Abstract Matrix metalloproteinases (MMP‐2 and MMP‐9) are key regulators of cancer
Yen Thi Nguyen +5 more
wiley +1 more source
Gastric Cancer: Pathobiology and Therapeutics
Gastric cancer is a multistep process driven by the interplay of microbial virulence, host epithelial injury, and evolving molecular reprogramming. Initiation involves pathogen‐induced epigenetic alterations and the early subversion of key oncogenic signaling networks, facilitating the transition from chronic injury to metaplasia and malignant ...
Ruixian Yu +16 more
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Vasculogenic mimicry and its clinical significance in medulloblastoma [PDF]
Vasculogenic mimicry (VM), a process involving the formation of a tubular structure by highly invasive and genetically dysregulated tumor cells, can supplement the function of blood vessels to transport nutrients and oxygen to maintain the growth of tumor cells in many malignant tumors.
Shi-yong, Wang +9 more
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Background Anti-angiogenesis therapy that targets VEGF is one of the important treatment strategies in advanced ovarian cancer. However, depending on the pharmaceutical agent, treatment can have undesirable side effects.
Ying Chen +3 more
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This article systematically elucidates the molecular mechanisms of colorectal precancerous lesions, introduces cutting‐edge research tools like multi‐omics and organoids, and highlights the potential and prospects of natural products such as berberine, resveratrol, and curcumin in preventing and intervening in colorectal carcinogenesis by modulating ...
Shunji Liu +6 more
wiley +1 more source
Brucine inhibits vasculogenic mimicry of breast cancer cell lines in vitro and the related mechanism
Background and purpose: The existence of vasculogenic mimicry (VM) in a large variety of highly invasive tumors, such as breast cancer, may lead to less effective traditional anti-angiotherapy.
索明珠
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Endometrial cancer (EC), a major gynecologic malignancy and a representative “cold tumor”, exhibits a tumor immune microenvironment (TIME) influenced by a broad range of cellular and molecular elements, immunosuppressive signals, and pathways of immune evasion.
Jingxuan Ye +4 more
wiley +1 more source
Introduction: Neoplastic cells of various malignant tumours may induce formation of “vascular channels”which are not lined with endothelium. This phenomenon has been called “vasculogenic mimicry”.
Jarosław Daniłoś +2 more
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