Results 31 to 40 of about 4,131 (170)

Triptonide effectively inhibits triple-negative breast cancer metastasis through concurrent degradation of Twist1 and Notch1 oncoproteins

Breast Cancer Research, 2021
Background Triple-negative breast cancer (TNBC) is highly metastatic and lethal. Due to a lack of druggable targets for this disease, there are no effective therapies in the clinic.
Mengli Zhang, Mei Meng, Yuxi Liu, Jindan Qi, Zhe Zhao, Yingnan Qiao, Yanxing Hu, Wei Lu, Zhou Zhou, Peng Xu, Quansheng Zhou   +10 more
doaj   +1 more source

Inhibition of Dimethylarginine Dimethylaminohydrolase (DDAH) Enzymes as an Emerging Therapeutic Strategy to Target Angiogenesis and Vasculogenic Mimicry in Cancer

Frontiers in Oncology, 2020
The small free radical gas nitric oxide (NO) plays a key role in various physiological and pathological processes through enhancement of endothelial cell survival and proliferation.
Julie-Ann Hulin, Ekaterina A. Gubareva, Natalia Jarzebska, Natalia Jarzebska, Roman N. Rodionov, Arduino A. Mangoni, Sara Tommasi   +6 more
doaj   +1 more source

Zoledronic acid inhibits vasculogenic mimicry in murine osteosarcoma cell line in vitro

BMC Musculoskeletal Disorders, 2011
Background To study the effects of zoledronic acid (ZA) on the vasculogenic mimicry of osteosarcoma cells in vitro. Methods A Three-dimensional culture of LM8 osteosarcoma cells on a type I collagen matrix was used to investigate whether osteosarcoma ...
Lin Tao, Xu Weihua, Yang Shuhua, He Xianfeng, Fu Dehao, Feng Xiaobo   +5 more
doaj   +1 more source

Vasculogenic Mimicry in Tumors

The American Journal of Pathology, 2000
In 1999, Maniotis reported that blood vessels of highly aggressive uveal melanomas are formed by tumor cells instead of endothelial cells. He termed this novel concept in tumor vascularization vasculogenic mimicry (VM). Since then, VM has been seen in several malignant tumor types such as breast cancer, liver cancer, glioma, ovarian cancer, melanoma ...
Shiwu, Zhang, Danfang, Zhang, Baocun, Sun   +2 more
openaire   +3 more sources

The development of tumour vascular networks

Communications Biology, 2021
Fouladzadeh, Dorraki and colleagues investigate the development of angiogenic networks for in vitro cancer cell lines. They demonstrate that during the growth stages of vasculogenic mimicry, the number of edges and vertices decreases but the edge length ...
Anahita Fouladzadeh, Mohsen Dorraki, Kay Khine Myo Min, Michaelia P. Cockshell, Emma J. Thompson, Johan W. Verjans, Andrew Allison, Claudine S. Bonder, Derek Abbott   +8 more
doaj   +1 more source

Cell-dependent regulation of vasculogenic mimicry by carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1)

Biochemistry and Biophysics Reports, 2020
Vasculogenic mimicry (VM) promotes tumor migration, metastasis, and invasion in various types of cancer, but the relationship between VM and these phenotypes remains undefined. In this study, we examined carcinoembryonic antigen cell adhesion molecule 1 (
Soichiro Hayashi, Yoshiyuki Osada, Kazuki Miura, Siro Simizu   +3 more
doaj   +1 more source

Mechanisms of vasculogenic mimicry in hypoxic tumor microenvironments [PDF]

Molecular Cancer, 2021
Abstract Background Vasculogenic mimicry (VM) is a recently discovered angiogenetic process found in many malignant tumors, and is different from the traditional angiogenetic process involving vascular endothelium. It involves the formation of microvascular channels composed of tumor cells; therefore, VM is considered a ...
Xiaoxu Wei, Yunhua Chen, Xianjie Jiang, Miao Peng, Yiduo Liu, Yongzhen Mo, Daixi Ren, Yuze Hua, Boyao Yu, Yujuan Zhou, Qianjin Liao, Hui Wang, Bo Xiang, Ming Zhou, Xiaoling Li, Guiyuan Li, Yong Li, Wei Xiong, Zhaoyang Zeng   +18 more
openaire   +3 more sources

Canstatin represses glioma growth by inhibiting formation of VM-like structures

Translational Neuroscience, 2021
Vasculogenic mimicry (VM) is different from classical tumor angiogenesis and does not depend on endothelial cells. VM is closely related to the prognosis of various cancers. Canstatin was first identified as an endogenous angiogenesis inhibitor.
Ma Yuqiang, Wu Tao, Zhou Houjie, He Guilu, Li Yifei, Wang Bocheng, Guo Qiang, Chen Baodong, Li Weiping   +8 more
doaj   +1 more source

II. Capsular vaso-mimicry formed by transgenic mammary tumor spheroids implanted ectopically into mouse dorsal skin fold: implications for cellular mechanisms of metastasis [v2; ref status: indexed, http://f1000r.es/11h]

F1000Research, 2013
Most cancer patients die of metastatic disease, not primary tumors, while biological mechanisms leading to metastases remain unclear and effective therapies are missing.
Halina Witkiewicz, Phil Oh, Jan E Schnitzer   +2 more
doaj   +1 more source

Monitoring Neovascularization of Malignant Solid Tumors with Horseradish Peroxidase-Functionalized Near-Infrared-II PbS Quantum Dots

Chemical & Biomedical Imaging, 2023
The growth and metastasis of malignant solid tumors depend closely on new blood vessels. Vasculogenic mimicry provides a special pathway of blood supply during the early growth of malignant tumors, and real-time monitoring of its occurrence and ...
Lu-Lu Chen, Zhi-Gang Wang, Hao Zhang, Li-Ming Chen, Liang Zhao, Zhen-Ya Liu, Wei Zhao, Lin-Han Jiang, Ai-Xin Ma, Xiaohui Yang, Shu-Lin Liu, Shiwu Zhang, Dai-Wen Pang   +12 more
doaj   +1 more source