The FOXC2‐LAMA4 Axis Orchestrates Vasculogenic Mimicry and Immunosuppressive Niche Formation to Drive Metastatic Cascade in Renal Cell Carcinoma [PDF]
Advanced ScienceThe aggressive metastatic propensity of advanced clear cell renal cell carcinoma (ccRCC) originates from intratumoral heterogeneity. Through integrated single‐cell and spatial multi‐omics profiling, we identified a FOXC2+ tumor subpopulation endowed with
Jiaxi Yao +11 more
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Emerging strategies for targeting vasculogenic mimicry in breast cancer treatment [PDF]
Discover OncologyBreast cancer represents the most commonly diagnosed malignancy worldwide and is the fourth leading cause of cancer-related mortality. Approximately 2.3 million new cases of breast cancer were diagnosed worldwide in 2022, accounting for 11.6% of all ...
Nare Sekoba +3 more
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Unraveling vascular mechanisms in melanoma: roles of angiogenesis and vasculogenic mimicry in tumor progression and therapeutic resistance [PDF]
Cancer Biology & MedicineMelanoma, the most aggressive form of skin cancer, remains a significant clinical challenge due to the high metastatic potential and drug resistance. This review explores the pivotal roles of angiogenesis and vasculogenic mimicry in melanoma progression ...
Simona Serratì +9 more
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Microbial Metabolite Effects on Vasculogenic Mimicry in Metastatic Cancers [PDF]
CellsAggressive cancer cells can form new, functional blood vessel-like structures independently of endothelial cells, known as vasculogenic mimicry (VM), instead of the usual tumor blood vessel formation process.
Mohammad Kamalabadi Farahani +4 more
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Mechanisms of Vasculogenic Mimicry in Ovarian Cancer [PDF]
Frontiers in Oncology, 2019 Solid tumors carry out the formation of new vessels providing blood supply for growth, tumor maintenance, and metastasis. Several processes take place during tumor vascularization.
Lízbeth Ayala-Domínguez +9 more
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Vasculogenic mimicry in small cell lung cancer [PDF]
Nature Communications, 2016 Small cell lung cancer (SCLC) is characterised by prevalent circulating tumour cells (CTCs), early metastasis and poor prognosis. The authors show that SCLC patients have a rare CTC subset with a vasculogenic mimicry (VM) phenotype, and that VM is ...
Stuart C. Williamson +26 more
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LncRNAs Regulate Vasculogenic Mimicry in Human Cancers [PDF]
CellsVasculogenic mimicry (VM) has recently been discovered as an alternative mechanism for nourishing cancer cells in vivo. During VM, tumor cells align and organize themselves into three-dimensional (3D) channel-like structures to transport nutrients and ...
Eloísa Ibarra-Sierra +4 more
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A novel vasculogenic mimicry-related nomogram predicts prognosis in hepatocellular carcinoma [PDF]
Frontiers in GeneticsObjectiveHepatocellular carcinoma (HCC) is the most common type of liver cancer and has a poor prognosis. Vasculogenic mimicry (VM) is an angiogenic process associated with the growth and spread of malignant tumors.
Yun Zhong +23 more
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Expression patterns and clinical significance of vasculogenic mimicry-related genes in patients with head and neck squamous cell carcinoma [PDF]
Frontiers in ImmunologyBackgroundHead and neck squamous cell carcinoma (HNSCC) is one of the most prevalent malignant neoplasms worldwide. Despite advances in conventional therapies such as surgery, radiotherapy, and chemotherapy, many patients still have a poor prognosis due ...
Rui Lai, Xuanyu Gu, Yueyue Cai, Qiang Li
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Establishment and validation of a prognostic model based on vasculogenic mimicry-related gene clustering in ovarian cancer [PDF]
Frontiers in OncologyBackgroundAs a critical prognostic factor in ovarian cancer which is the most lethal gynecologic malignancy, vasculogenic mimicry (VM) has not been systematically incorporated into prognostic evaluation frameworks in ovarian cancer (OC). This underscores
Xueyuan Zhao +21 more
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