Results 41 to 50 of about 4,131 (170)

Platelets disrupt vasculogenic mimicry by cancer cells [PDF]

Scientific Reports, 2020
Abstract Tumour vasculature supports the growth and progression of solid cancers with both angiogenesis (endothelial cell proliferation) and vasculogenic mimicry (VM, the formation of vascular structures by cancer cells themselves) predictors of poor patient outcomes.
Carmela Martini, Emma J. Thompson, Stephanie R. Hyslop, Michaelia P. Cockshell, Brian J. Dale, Lisa M. Ebert, Anthony E. Woods, Emma C. Josefsson, Claudine S. Bonder   +8 more
openaire   +3 more sources

Overview on the Different Patterns of Tumor Vascularization

Cells, 2021
Angiogenesis is a crucial event in the physiological processes of embryogenesis and wound healing. During malignant transformation, dysregulation of angiogenesis leads to the formation of a vascular network of tumor-associated capillaries promoting ...
Domenico Ribatti, Francesco Pezzella
doaj   +1 more source

Trophoblastic vasculogenic mimicry in gestational choriocarcinoma [PDF]

Modern Pathology, 2011
Angiogenesis is a characteristic feature of solid tumors, which depend on the newly formed vasculature to prevent hypoxia and to sustain uncontrolled tumor cell proliferation. In this study, we investigated the blood supply system in 10 gestational choriocarcinomas on the basis of histopathological and immunohistochemical features.
openaire   +2 more sources

Advance in vasculogenic mimicry in ovarian cancer (Review)

Oncology Letters, 2023
Ovarian cancer (OC) is a common and highly prevalent malignant tumor in women, associated with a high mortality rate, easy recurrence and easy metastasis, which is predominantly at an advanced stage when detected in patients. This renders the cancer more difficult to treat, and consequently it is also associated with a low survival rate, being the ...
Tian, Xinyuan, Si, Qin, Liu, Menghe, Shi, Jianping, Zhao, Rongwei, Xiong, Yang, Yu, Lei, Cui, Hongwei, Guan, Haibin   +8 more
openaire   +2 more sources

CD93—An emerging vascular target in cancer therapy

British Journal of Pharmacology, EarlyView.
Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira, Stefano Barbera, Roberta Lugano, Anna Dimberg   +3 more
wiley   +1 more source

circMAN1A2 as an Isoform‐Resolved Circular RNA Hub in Cancer

Cancer Science, EarlyView.
circMAN1A2 as an isoform‐resolved circular RNA hub in cancer. circMAN1A2 is generated by back‐splicing of MAN1A2 pre‐mRNA, with alternative circularization producing multiple isoforms, including the predominant circMAN1A2(2–5). Its mechanistic interfaces include miRNA‐associated regulation, RBP binding/proteostasis control, BSJ‐mediated RNA–RNA pairing,
Hanyu Shang, Hui Wang, Yonghang Xu, Lingyun Geng, Yanqing Wang   +4 more
wiley   +1 more source

Therapeutic potential of vasculogenic mimicry in urological tumors

Frontiers in Oncology, 2023
Angiogenesis is an essential process in the growth and metastasis of cancer cells, which can be hampered by an anti-angiogenesis mechanism, thereby delaying the progression of tumors. However, the benefit of this treatment modality could be restricted, as most patients tend to develop acquired resistance during treatment.
Xinyu Lin, Xinyu Lin, Sheng Long, Sheng Long, Congcong Yan, Congcong Yan, Xiaofeng Zou, Xiaofeng Zou, Guoxi Zhang, Guoxi Zhang, Junrong Zou, Junrong Zou, Gengqing Wu, Gengqing Wu   +13 more
openaire   +3 more sources

Crosstalk Between Long Non-coding RNAs, Micro-RNAs and mRNAs: Deciphering Molecular Mechanisms of Master Regulators in Cancer

Frontiers in Oncology, 2019
Cancer is a complex disease, and its study requires deep understanding of several biological processes and their regulation. It is an accepted fact that non-coding RNAs are vital components of the regulation and cross-talk among cancer-related signaling ...
Eduardo López-Urrutia, Lilia P. Bustamante Montes, Diego Ladrón de Guevara Cervantes, Carlos Pérez-Plasencia, Carlos Pérez-Plasencia, Alma D. Campos-Parra   +5 more
doaj   +1 more source

Bone Grafts: Everything You Need to Know

Journal of Periodontal Research, EarlyView.
This review classifies bone grafts (autograft, allograft, xenograft, synthetic) by source and osteogenic/inductive/conductive potential, linking material properties and mechanisms to clinical indications in periodontal and dental regeneration. Key challenges—limited osteoinduction, poor vascularisation, unbalanced resorption, handling difficulties, and
Håvard Jostein Haugen, Javier Sanz, Giuseppe Perale, Augustine Mark Saiz, Mario Romandini, Maryam Rahmati   +5 more
wiley   +1 more source

The vasculogenic mimicry related signature predicts the prognosis and immunotherapy response in renal clear cell carcinoma

BMC Cancer
Background Clear cell carcinoma of the kidney is a common urological malignancy characterized by poor patient prognosis and treatment outcomes. Modulation of vasculogenic mimicry in tumor cells alters the tumor microenvironment and the influx of tumor ...
Yuming Gu, Qinqin Huang, Yun Wang, Haixia Wang, Zhenhua Xiang, Yu Xu, Xin Wang, Weiguo Liu, Aiju Wang   +8 more
doaj   +1 more source