Results 101 to 110 of about 86,075 (269)

Effects of tempol on renal medullary tissue hypoxia in an ovine model of Gram‐negative septic acute kidney injury

Experimental Physiology, EarlyView.
Abstract Renal arterial infusion of tempol (RAT) at the onset of Gram‐negative sepsis can prevent sepsis‐induced medullary tissue hypoxia and acute kidney injury (AKI). However, it is not known whether treatment with tempol at a clinically relevant time point of sepsis is similarly effective. Thus, we examined whether tempol can reverse renal medullary
Rachel Peiris, Anton Trask‐Marino, Alemayehu Jufar, Ashenafi H. Betrie, Adam Southon, Sally G. Hood, Rinaldo Bellomo, Abraham H. Hulst, Clive N. May, Connie P. C. Ow, Yugeesh R. Lankadeva   +10 more
wiley   +1 more source

Uncovering the impact of the cardiovascular system on cerebrovascular health using MRI

Experimental Physiology, EarlyView.
Abstract Human cerebrovasculature is finely tuned to enable local changes in blood flow to meet the brain's demands, whilst protecting the brain from systemic changes in blood pressure, both acutely during a heartbeat and chronically over time. This review summarises cerebrovascular structure and function, their role in disease and neurodegeneration ...
Ian D. Driver, Kevin Murphy
wiley   +1 more source

Differential sensitivity of basal and acetylcholine-induced activity of nitric oxide to blockade by asymmetric dimethylarginine (ADMA) in the rat aorta [PDF]

, 2010
<b>Background and purpose</b>: Previous work has shown that NG-monomethyl-l-arginine (l-NMMA) paradoxically inhibits basal, but not ACh-stimulated activity of nitric oxide in rat aorta.
Archer, Boger, Cocks, De Gennaro Colonna, Dora, Dudzinski, Feng, Fleming, Frew, Fulton, Gallis, Hobbs, Jackson, Jin, Leiper, Liu, Martin, Martin, Miller, Moore, Olken, Overend, Palmer, Rapoport, Rees, Rees, Siroen, Vallance, Vallance, Vladimirova-Kitova   +29 more
core   +3 more sources

ISA‐vasodilatation: improvement of organ perfusion. [PDF]

British Journal of Clinical Pharmacology, 1987
1. In almost all forms of established hypertension the increase in blood pressure can be attributed to increased total peripheral vascular resistance. 2. beta‐adrenoceptor blocking compounds, which are frequently used as first‐line therapy in hypertension, may compromise blood flow to vital organs in view of the fact that they reduce cardiac output ...
openaire   +2 more sources

Nitrite supplementation alleviates cerebrovascular dysfunction in chronically stressed mice, but cognitive decline remains

Experimental Physiology, EarlyView.
Abstract This study aimed to determine whether sodium nitrite supplementation prevented chronic stress‐induced cerebrovascular dysfunction and cognitive decline. We hypothesize that nitrite supplementation will prevent the oxidative environment and cerebrovascular dysfunction associated with chronic stress and maintain cognitive health.
Emily Burrage, Tyler Coblentz, Saina S. Prabhu, Nicole M. Eminhizer, Ryan Childers, Randall W. Bryner, Sara E. Lewis, Brooke A. Maxwell, Evan R. DeVallance, Eric E. Kelley, Paul D. Chantler   +10 more
wiley   +1 more source

Effects of thyroxine replacement on endothelial function and carotid artery intima-media thickness in female patients with mild subclinical hypothyroidism

Clinics, 2011
BACKGROUND: Previous studies have suggested an association between subclinical hypothyroidism and coronary artery disease that could be related to changes in serum lipids or endothelial dysfunction.
Monica Dias Cabral, Patricia Teixeira, Debora Soares, Sandra Leite, Elizabeth Salles, Mario Waisman   +5 more
doaj   +1 more source

Robert F. Furchgott, Nobel laureate (1916-2009) - a personal reflection [PDF]

, 2009
Robert F. Furchgott, pharmacologist and joint winner of the Nobel Prize for Medicine or Physiology (1998) died on the 12th of May 2009 aged 92. By unlocking the astonishingly diverse biological actions of nitric oxide, Furchgott leaves behind a rich ...
Ambache, Andrews, Bowman, Bowman, Bowman, Bowman, de Andrade, Farhat, Furchgott, Furchgott, Furchgott, Furchgott, Furchgott, Furchgott, Félétou, Garland, Gillespie, Gillespie, Gillespie, Gillespie, Gryglewski, Ignarro, Katsuki, Li, Martin, Martin, Martin, Martin, Martin, Megson, Michel, Moore, Ng, Palmer, Palmer, Ramagopal, Rapoport, Rees, Rees, Rubanyi, Vanhoutte   +40 more
core   +2 more sources

Endothelial dysfunction: a comprehensive appraisal

Cardiovascular Diabetology, 2006
The endothelium is a thin monocelular layer that covers all the inner surface of the blood vessels, separating the circulating blood from the tissues. It is not an inactive organ, quite the opposite.
Vilariño Jorge O, Nordaby Roberto A, Esper Ricardo J, Paragano Antonio, Cacharrón José L, Machado Rogelio A   +5 more
doaj   +1 more source

Evidence of endothelial dysfunction in the development of Alzheimer's disease : Is Alzheimer's a vascular disorder? [PDF]

, 2013
Acknowledgements Dr Soiza is funded by an NRS Career Research Fellowship.
Kelleher, Rory J., Soiza, Roy L
core   +1 more source

Influence of estimated training status on anti and pro-oxidant activity, nitrite concentration, and blood pressure in middle-aged and older women [PDF]

, 2017
The purpose of this study was to compare the association between anti and pro-oxidant activity, nitrite concentration, and blood pressure (BP) in middle-aged and older women with different levels of estimated training status (TS). The sample consisted of
Amaral, Sandra L., Brito, Janaina de Oliveira, da Silva, Roberta F., De Angelis, Kátia, Dias, Danielle da Silva, Jacomini, André M., Llesuy, Susana Francisca, Monteiro, Henrique L., Zago, Anderson S.   +8 more
core   +1 more source