Results 41 to 50 of about 140,646 (292)

In vivo Stimulus-Induced Vasodilation Occurs without IP3 Receptor Activation and May Precede Astrocytic Calcium Increase

Journal of Neuroscience, 2013
Calcium-dependent release of vasoactive gliotransmitters is widely assumed to trigger vasodilation associated with rapid increases in neuronal activity. Inconsistent with this hypothesis, intact stimulus-induced vasodilation was observed in inositol 1,4 ...
Krystal Nizar, Hana Uhlířová, Peifang A. Tian, P. Saisan, Qun Cheng, L. Reznichenko, Kimberly L. Weldy, Tyler C. Steed, Vishnu B. Sridhar, Christopher L. MacDonald, Jianxia Cui, Sergey L. Gratiy, S. Sakadžić, D. Boas, T. I. Beka, G. Einevoll, Ju Chen, E. Masliah, A. Dale, G. Silva, A. Devor   +20 more
semanticscholar   +1 more source

Lattice Structures for Bone Replacement: The Intersection of Bone Biomechanics, Lattice Design, and Additive Manufacturing

Advanced Materials Technologies, EarlyView.
This review outlines how understanding bone's biology, hierarchical architecture, and mechanical anisotropy informs the design of lattice structures that replicate bone morphology and mechanical behavior. Additive manufacturing enables the fabrication of orthopedic implants that incorporate such structures using a range of engineering materials ...
Stylianos Kechagias, Maxwell J. Munford, Frederik C.H. Masure, Richard J. van Arkel, Reece N Oosterbeek   +4 more
wiley   +1 more source

The New Nitric Oxide Donor, FOR 911B, Induces Relaxation in Isolated Rat Aorta Involving the NO/sGC/cGMP Pathway and K⁺ Channels

Receptors
Background: Nitric oxide (NO) is a gaseous molecule considered to be a protagonist in the dilation of blood vessels, and its property and/or bioavailability are reduced in pathophysiological conditions such as cardiovascular diseases.
Mirelly Cunha da Silva, Florêncio Sousa Gouveia Júnior, Thyago Moreira de Queiroz   +2 more
doaj   +1 more source

Ethyl Acetate Fraction and Isolated Phenolics Derivatives from Mandevilla moricandiana Identified by UHPLC-DAD-ESI-MSⁿ with Pharmacological Potential for the Improvement of Obesity-Induced Endothelial Dysfunction

Pharmaceutics, 2021
Endothelial dysfunction in obesity plays a key role in the development of cardiovascular diseases, and it is characterized by increased vascular tonus and oxidative stress. Thus, this study aimed to investigate the vasodilatory and antioxidant activities
Leticia L. D. M. Ferreira, Valéria de F. Leão, Cinthya M. de Melo, Thelma de B. Machado, Ana Claudia F. Amaral, Leandro L. da Silva, Naomi K. Simas, Michelle F. Muzitano, Ivana C. R. Leal, Juliana M. Raimundo   +9 more
doaj   +1 more source

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

Advanced Materials Technologies, EarlyView.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang, He Huang, Hongliang Dong, Qiang Ma, Hongyan Jin   +4 more
wiley   +1 more source

Dissociation between vasodilation and Leishmania infection-enhancing effects of sand fly saliva and maxadilan

Memorias do Instituto Oswaldo Cruz, 2001
In this study, the ability of maxadilan and Lutzomyia longipalpis salivary gland lysate to enhance the infection of CBA mice by Leishmania major and of BALB/c mice by L. braziliensis was tested.
Fábio Castro-Sousa, Moacir Paranhos-Silva, Ítalo Sherlock, Mariza S Paixão, Lain C Pontes-de-Carvalho, Washington LC dos-Santos   +5 more
doaj   +1 more source

Nitric Oxide as a Central Molecule in Hypertension: Focus on the Vasorelaxant Activity of New Nitric Oxide Donors

Biology, 2021
Cardiovascular diseases include all types of disorders related to the heart or blood vessels. High blood pressure is an important risk factor for cardiac complications and pathological disorders.
Gabriela Maria da Silva, Mirelly Cunha da Silva, Déborah Victória Gomes Nascimento, Ellen Mayara Lima Silva, Fabíola Furtado Fialho Gouvêa, Luiz Gonzaga de França Lopes, Alice Valença Araújo, Kelli Nogueira Ferraz Pereira, Thyago Moreira de Queiroz   +8 more
doaj   +1 more source

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis

Advanced Science, EarlyView.
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha, Sofya Kosmynina, Amandine Verocq, Keremsah Ozen, Ines Tekia, Hugo Bussy, Marie Ramirez, Dima Sabbah, Chloe Goemans, Valerie Vandenbempt, Esteban N. Gurzov, Sumeet Pal Singh, Nicolas Baeyens   +12 more
wiley   +1 more source

Vasodilation increases pulse pressure variation, mimicking hypovolemic status in rabbits

Clinics, 2010
OBJECTIVE: To test the hypothesis that pulse pressure respiratory variation (PPV) amplification, observed in hypovolemia, can also be observed during sodium nitroprusside (SNP)-induced vasodilation.
Glauco A Westphal, Anderson Roman Gonçalves, Antônio Bedin, Raquel Bissacotti Steglich, Eliezer Silva, Luiz Francisco Poli-de-Figueiredo   +5 more
doaj   +1 more source

Magnetically‐Induced Suppression of Oxidative Stress Prevents Venous Thrombosis

Advanced Science, EarlyView.
Venous thromboembolism (VTE) remains a leading cause of cardiovascular mortality. This study demonstrates that static magnetic fields (SMF) offer a novel non‐pharmacological intervention against VTE by mitigating endothelial oxidative stress. Mechanistically, SMF elevates intracellular Ca2+, boosts ATP production, and suppresses NOX4‐mediated ROS ...
Nana Zhang, Yirong An, Shiran Tao, Shenao Qu, Minge Wu, Guantong Fang, Ziqing Chen, Weilun Song, Haoze Leng, Rongqian Wu, Yi Lyu, Xiaoli Liu, Dinghui Dong   +12 more
wiley   +1 more source