Results 41 to 50 of about 99,683 (99)

Vitamin E Attenuates Red-Light-Mediated Vasodilation: The Benefits of a Mild Oxidative Stress

Antioxidants
Red light (670 nm) energy controls vasodilation via the formation of a transferable endothelium-derived nitric oxide (NO)-precursor-containing substance, its intracellular traffic, and exocytosis. Here we investigated the underlying mechanistic effect of
Agnes Keszler, Dorothee Weihrauch, Brian Lindemer, Grant Broeckel, Nicole L. Lohr   +4 more
doaj   +1 more source

OGG1 Preserves Endothelial-Dependent Vasodilation and Regulates the Frequency and Spatial Area of Endothelial Calcium Signals

Biomolecules
Endothelial calcium dysregulation underlies impairments in endothelial-dependent vasodilation (EDV), contributing to vascular disease progression. Repletion of 8-oxoguanine DNA glycosylase (OGG1), an enzyme involved in base excision repair, has been ...
Takreem Aziz, Larysa Yuzefovych, Lyudmila Rachek, Mark S. Taylor, Christopher M. Francis   +4 more
doaj   +1 more source

Integrating endothelium-derived hyperpolarization, nitric oxide, and prostacyclin pathways: the multimodal potential of human tissue kallikrein-1

Vascular Biology
Endothelial cells regulate vascular tone by releasing nitric oxide (NO) and prostacyclin (PGI2), as well as by initiating hyperpolarization of vascular smooth muscle cells through K+ channels and myoendothelial coupling.
Paolo Madeddu, Styliani Goulopoulou, David Wambeke   +2 more
doaj   +1 more source

Vasomotor responses are similar between outbred UM-HET3 and inbred C57BL/6J male and female mouse mesenteric resistance arteries

Frontiers in Physiology
ObjectiveGenetically diverse UM-HET3 (HET3) mice have emerged as a more robust model of human large artery dysfunction than the commonly used inbred C57BL/6J (C57) mice. However, HET3 resistance artery function has not been examined.
Robin C. Looft-Wilson, Surya Naraynan, Kathleen Salmon, Ethan Wunibald, Brian Simmons, Connor Haitz, Vishakha Shah, Margaret Xu   +7 more
doaj   +1 more source

Dilatory effects and safety of a polyphenol-rich extract of Steganotaenia araliacea Hochst (Apiaceae) on rat aortic rings

Frontiers in Pharmacology
BackgroundHypertension is a major global public health concern. Many communities in developing countries still rely on medicinal plants as a source of primary healthcare for treatment of hypertension instead of conventional antihypertensive drugs ...
Newton Simfukwe, Lavina Prashar, James Nyirenda, Fastone Mathew Goma, Christian Chinyere Ezeala   +4 more
doaj   +1 more source

The Role of the NO/cGMP Pathway and SKCa and IKCa Channels in the Vasodilatory Effect of Apigenin 7-Glucoside

Molecules
This study aimed to elucidate the vasorelaxant mechanism of action for apigenin 7-glucoside (A7G) by integrating computational and ex vivo pharmacological approaches.
Maria Luiza Fidelis da Silva, Erdi Can Aytar, Arquimedes Gasparotto Junior   +2 more
doaj   +1 more source

Spironolactone Induces Vasodilation by Endothelium-Dependent Mechanisms Involving NO and by Endothelium-Independent Mechanisms Blocking Ca²⁺ Channels

Journal of Xenobiotics
Background: Spironolactone (SPI) is a diuretic widely used to treat cardiovascular diseases (CVD) and is non-specific for mineralocorticoid receptors (MR) and with an affinity for progesterone (PR) and androgen (AR) receptors.
Margarida Lorigo, João Amaro, Elisa Cairrao   +2 more
doaj   +1 more source

Modeling of Blood Flow Dynamics in Rat Somatosensory Cortex

Biomedicines
Background: The cerebral microvasculature forms a dense network of interconnected blood vessels where flow is modulated partly by astrocytes. Increased neuronal activity stimulates astrocytes to release vasoactive substances at the endfeet, altering the ...
Stéphanie Battini, Nicola Cantarutti, Christos Kotsalos, Yann Roussel, Alessandro Cattabiani, Alexis Arnaudon, Cyrille Favreau, Stefano Antonel, Henry Markram, Daniel Keller   +9 more
doaj   +1 more source

In vivo comparative study of ocular vasodilation, a relative indicator of hyperemia, in guinea pigs following treatment with bimatoprost ophthalmic solutions 0.01% and 0.03%

Clinical Ophthalmology, 2010
Abayomi B Ogundele, David Earnest, Marsha A McLaughlinAlcon Research, Limited, Fort Worth, TX, USAObjective: The objective of this in vivo study was to compare the incidence of vasodilation in guinea pigs following topical administration of bimatoprost ...
Abayomi B Ogundele, David Earnest, Marsha A McLaughlin   +2 more
doaj  

Corrigendum: Current Knowledge on the Vascular Effects of Menthol

Frontiers in Physiology, 2020
Henrique Silva, Henrique Silva, Henrique Silva, Henrique Silva   +3 more
doaj   +1 more source