Results 71 to 80 of about 25,436 (310)

The Road to Stockholm: [Dr. Bruce Merrifield] [PDF]

open access: yes, 1985
Rockefeller University Research Profiles are a series of scientific profiles that were published quarterly, from 1980-1990, by the Rockefeller University. Each issue features the research and achievements of an individual Rockefeller University scientist.
Bardossi, Fulvio, Schwartz, Judith N.
core   +1 more source

A Polyproline type II Peptidomimetic Disrupts a Grb2 SH3C Domain Protein‐protein Interaction Implicated in Breast Cancer

open access: yesChemBioChem, Accepted Article.
Given the essential role of protein‐protein interactions (PPIs) in cellular signalling pathways their selective modulation is of great therapeutic interest. Mimicry of secondary structural protein elements has emerged as a promising strategy, with various scaffolds reproducing recognition surfaces of α‐helical and β‐strand/sheet proteins.
James Luccarelli   +4 more
wiley   +1 more source

Protein co-evolution, co-adaptation and interactions [PDF]

open access: yes, 2008
Co-evolution has an important function in the evolution of species and it is clearly manifested in certain scenarios such as host–parasite and predator–prey interactions, symbiosis and mutualism.
Alfonso Valencia   +10 more
core   +2 more sources

A Rare Case of Nitroglycerin Resistant Coronary Arterial Vasospasm During Coronary Artery Bypass Surgery

open access: yesCatheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Coronary artery vasospasm following coronary artery bypass grafting (CABG) is a rare but potentially life‐threatening complication that can lead to myocardial ischemia, arrhythmias, and cardiogenic shock. Nitroglycerin‐resistant vasospasm, particularly involving the left main coronary artery (LMCA), poses significant diagnostic and ...
Dina Soliman   +3 more
wiley   +1 more source

Angiotensin II AT1 Receptor Blockade Changes Expression of Renal Sodium Transporters in Rats with Chronic Renal Failure [PDF]

open access: yes, 2005
We aimed to examine the effects of angiotensin II AT1 receptor blocker on the expression of major renal sodium transporters and aquaporin-2 (AQP2) in rats with chronic renal failure (CRF).
Beutler   +36 more
core   +2 more sources

An Efficient Thiol‐ene Mediated Protocol for Thiolated Peptide Synthesis and On‐Resin Diversification

open access: yesChemistry – A European Journal, EarlyView.
Herein, a sequential acyl‐thiol‐ene/S‐deacetylation protocol for selective installation of thiol residues onto synthetic peptides, on‐resin, is demonstrated. The hydrothiolation/S‐deacetylation protocol offers a novel synthetic tool for direct peptide conjugation on‐resin and for the preparation of novel disulfide containing neuropeptides displaying ...
Nikita Ostrovitsa   +5 more
wiley   +1 more source

Analytical methods for the quantitative determination of oxytocin [PDF]

open access: yes, 2010
Oxytocin is a clinically important nonapeptide that is used for the induction and/or augmentation of labor and is normally administered as a slow intravenous infusion diluted with normal saline or Ringer’s lactate solution. Oxytocin is also indicated for
Chaibva, F A, Walker, Roderick
core   +1 more source

Harnessing Viral Proteases for Cellular and Molecular Engineering

open access: yesChemistry–Methods, EarlyView.
Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui   +2 more
wiley   +1 more source

Severe hyponatremia induced by the association of fluoxetine, hydrochlorothiazide andcaptopril in a young patient [PDF]

open access: yes, 2009
Descrevemos um caso de hiponatremia grave, com um dos níveis séricos de sódio mais baixos da literatura, secundário ao uso de fluoxetina, captopril e hidroclorotiazida.
Alves, Luíza Hama   +4 more
core   +2 more sources

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