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Role of Hexokinase and VDAC in Neurological Disorders
Current Molecular Pharmacology, 2016Several neurological diseases such as bipolar disorders and schizophrenia are linked to impaired brain energy metabolism. A key feature of brain bioenergetics is hexokinase (HK) binding to the outer mitochondrial membrane through the voltage dependent anion channel (VDAC).
José César, Rosa +1 more
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VDAC, a Channel in the Outer Mitochondrial Membrane
1996Proteins that form aqueous channels in membranes generate conduction pathways with a variety of shapes and sizes. Perhaps the largest channel-forming protein is the 2-MDa ryanodine receptor while the smallest may be gramicidin. However, the size of the conducting pathway is not correlated with the amount of protein mass needed to make up the structure,
M, Colombini, E, Blachly-Dyson, M, Forte
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Gramicidin, VDAC, porin and perforin channels
Current Opinion in Cell Biology, 1990This review covers the miscellaneous channels that do not fall w=ithin the domain of the other reviews in this section. Three different channel systems will be reviewed: the gramicidin A channel; the large weakly selective channels that are present in the outer membrane of mitochondria (VDACs) and bacteria (porin); and the large channels whose function
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Mitochondrial apoptosis without VDAC
Nature Cell Biology, 2007Voltage-dependent anion channels (VDACs) are thought to participate in mitochondrial-membrane permeabilization, an event that frequently delimits the frontier between cell life and death. Recent work casts doubts on their contribution to mitochondrial cell death.
Lorenzo Galluzzi, Guido Kroemer
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Science, 2008
A channel that allows diffusion of metabolites across the mitochondrial outer membrane forms an unusual 19-stranded β barrel with a pore size of about 25 angstroms.
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A channel that allows diffusion of metabolites across the mitochondrial outer membrane forms an unusual 19-stranded β barrel with a pore size of about 25 angstroms.
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Editorial: VDAC As a Pharmaceutical Target
Current Medicinal Chemistry, 2018openaire +3 more sources
VDAC function in a cellular context
2004Trafficking of metabolites across the outer mitochondrial membrane is believed to be mediated primarily by the pore forming oltage-ependent anion channel, VDAC (also known as mitochondrial porin). An expanding body of in vitro studies strongly suggest that the pore formed by VDAC can be regulated in a number of ways that implicate it as a site for the ...
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Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson’s Disease: The Emerging Role of VDAC
Biomolecules, 2021Federica Zinghirino +2 more
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