Results 191 to 200 of about 17,038 (231)

The low-dose CHK1 inhibitor prexasertib triggers VDAC1 dephosphorylation to activate mtDNA-STING signaling and synergize immunotherapy.

Cell Reports
CHK1 inhibitors exhibit dose-limiting toxicity despite potent tumor cytotoxicity in clinical trials. Here, we reveal that low-dose prexasertib induces mtDNA damage by impairing repair machinery, triggering cytosolic mtDNA release via VDAC1 to activate ...
Yu Fu, Xiaoyan Kang, Wenting Li, Zanhong Wang, Wanwan Luo, Bin Yang, Yaoyuan Cui, Funian Lu, T. Qin, Xingyuan Hu, Jingjing Yin, Xi Li, Junpeng Fan, Beibei Wang, Gang Chen, Rourou Xiao, Zhiqiang Han, Ensong Guo, Xu Qin   +18 more
semanticscholar   +1 more source

Resveratrol’s Pro-Apoptotic Effects in Cancer Are Mediated Through the Interaction and Oligomerization of the Mitochondrial VDAC1

International Journal of Molecular Sciences
Resveratrol is a naturally occurring phenolic compound found in various foods such as red wine, chocolate, peanuts, and blueberries. Both in-vitro and in-vivo studies have shown that it has a broad spectrum of pharmacological effects such as providing ...
T. Raviv, A. Shteinfer-Kuzmine, Meital M. Moyal, V. Shoshan-Barmatz   +3 more
semanticscholar   +1 more source

PFOS causes lysosomes-regulated mitochondrial fission through TRPML1-VDAC1 and oligomerization of MCU/ATP5J2.

Journal of Hazardous Materials
Perfluorooctane sulfonate (PFOS), a listed persistent organic pollutant, poses risks to human health and is closely linked to chronic metabolic diseases. Although the role of mitochondrial fission in these diseases has garnered attention, whether and how
Wei Yang, Yu Li, Ruzhen Feng, Peiyao Liang, Kefan Tian, Lingli Hu, Kejing Wang, Tianming Qiu, Jingyuan Zhang, Xiance Sun, X. Yao   +10 more
semanticscholar   +1 more source

Resveratrol protects cardiomyocytes against ischemia/reperfusion-induced ferroptosis via inhibition of the VDAC1/GPX4 pathway.

European Journal of Pharmacology
The present study aimed to explore how resveratrol (Res) confers myocardial protection by attenuating ferroptosis. In vivo and in vitro myocardial ischemia/reperfusion injury (MIRI) models were established, with or without Res pretreatment.
Tie Hu, Hua-Xi Zou, Zeyu Zhang, Yi-Cheng Wang, Fajia Hu, Wen-Xiong Huang, Ji-chun Liu, Song-Qing Lai, Huang Huang   +8 more
semanticscholar   +1 more source

VDAC1 Inhibition Protects Against Noise‐Induced Hearing Loss via the PINK1/Parkin Pathway

CNS Neuroscience & Therapeutics
This study examined the effect of 4,4′‐diisothiocyanostilbene‐2,2′‐disulfonic acid (DIDS), an anion channel blocker of voltage‐dependent anion channel 1 (VDAC1), on noise‐induced hearing loss (NIHL) and its underlying mechanisms.
Yuchen Jin, Wenqi Dong, Yumeng Jiang, Lingkang Dong, Zhuangzhuang Li, Dongzhen Yu   +5 more
semanticscholar   +1 more source

Mitochondrial Ferritin Overexpression Attenuates Ferroptosis and Mitochondrial Dysfunction by Reducing VDAC1 to Relieve MI/RI‐Induced Damage

Journal of Cellular and Molecular Medicine
Ischaemic cardiomyopathy is becoming one of the most prevalent cardiovascular diseases among the global elderly population. However, the underlying molecular mechanisms remain incompletely understood.
Yong Yuan, Xiu-qi Wang, Hua Xu, Lanxiang Liu, Jichun Liu, Songqing Lai, Huang Huang   +6 more
semanticscholar   +1 more source

VDAC1 is a target for pharmacologically induced insulin hypersecretion in β cells

Cell Reports
SUMMARY β cells are dysfunctional in type 2 diabetes (T2D) and congenital hyperinsulinism (HI), but the mechanisms linking hypersecretion to β cell failure are poorly understood.
Gitanjali Roy, Andrea Ordóñez, D. Binns, Karina Rodrigues-dos-Santos, Michael B Kwakye, George C. King, Rachel L Kuntz, Noyonika Mukherjee, Andrew T. Templin, Zhiyong Tan, Timothy I. Richardson, E. Doud, Amber L. Mosley, K. Schueler, Christopher H. Emfinger, A. Attie, M. Keller, Travis S. Johnson, Michael A. Kalwat   +18 more
semanticscholar   +1 more source

Knockdown of VDAC1 Promotes Ferroptosis in Diffuse Large B‐Cell Lymphoma

Hematological Oncology
Diffuse large B‐cell lymphoma (DLBCL) is a prevalent subtype of non‐Hodgkin's lymphoma (NHL). Ferroptosis is a novel form of cell death involved in multiple tumor development.
Chuanming Lin, Liuyan Xin, Shuiling Xie
semanticscholar   +1 more source

Resveratrol inhibits autophagy in cardiomyocytes subjected anoxia/reoxygenation injury: involved in VDAC1/PINK1/Parkin pathway.

Toxicology and Applied Pharmacology
Resveratrol has confirmed effectiveness in alleviating myocardial ischemia/reperfusion(I/R) injury. However, the underlying mechanisms remain unclear. Mitochondrial dysfunction in injured cardiomyocytes activates autophagy, and excessive autophagy during
Ying Zhou, Yongzhen Huang, Haiyan Liang, Xiaomei Yang, Shuli Zhang, Yi-Ning Huang, Yanping Wan, Hang Zhou, A. Huang, Yue Chen, Xiao Li, Yian Peng, Z. Liao   +12 more
semanticscholar   +1 more source

Citrinin-Induced Intestinal Onset of Pyroptosis via the IP3R1-GRP75-VDAC1 Complex-Mediated Mitochondrial Oxidative Stress.

Journal of Agricultural and Food Chemistry
Citrinin (CTN) is commonly found in animal feed and stored grains and poses a serious threat to human and animal health. Formation of the IP3R1-GRP75-VDAC1 complex has been shown to play a key role in intestinal defense against harmful stimuli, but the ...
Yuanyuan Li, Qike Zhang, Xiaofang Liu, Yongkang Wang, Chenglin Yang, You Wu, Bo Xiao, Yiya Feng, Aoao Wu, J. Yi, Jing Wu, Zengenni Liang, Zhihang Yuan   +12 more
semanticscholar   +1 more source