Results 171 to 180 of about 11,641 (203)

Preserving Insulin Secretion in Diabetes by Inhibiting VDAC1 Overexpression and Surface Translocation in β Cells [PDF]

Cell Metabolism, 2019
Type 2 diabetes (T2D) develops after years of prediabetes during which high glucose (glucotoxicity) impairs insulin secretion. We report that the ATP-conducting mitochondrial outer membrane voltage-dependent anion channel-1 (VDAC1) is upregulated in ...
Albert Salehi, Leif Groop, Enming Zhang
exaly   +2 more sources

VDAC1 as a Player in Mitochondria-Mediated Apoptosis and Target for Modulating Apoptosis

Current Medicinal Chemistry, 2018
Background: The voltage-dependent anion channel 1 (VDAC1), an outer mitochondria membrane protein, functions as a mitochondrial governor, controlling transport of metabolites in and out of the mitochondria and energy production, while also coordinating ...
Quan Chen, Varda Shoshan-Barmatz, Yakov Krelin   +2 more
exaly   +2 more sources

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WDR26/MIP2 interacts with VDAC1 and regulates VDAC1 expression levels in H9c2 cells

Free Radical Biology and Medicine, 2018
MIP2, one of WDR26 isoforms, encodes a 498 amino acid protein with an amino-terminal CTLH domain and five carboxyl-terminal WD40 motifs. MIP2 is localized to the mitochondria and protects cardiomyocytes against oxidative stress; however, nothing is known about how MIP2 confers its cytoprotection.
Lei, Jiang, Hao, Wang, Guangbin, Chen, Yansheng, Feng, Jiang, Zou, Meidong, Liu, Ke, Liu, Nian, Wang, Huali, Zhang, Kangkai, Wang, Xianzhong, Xiao   +10 more
openaire   +2 more sources

Dominant-negative VDAC1 mutants reveal oligomeric VDAC1 to be the active unit in mitochondria-mediated apoptosis

Biochemical Journal, 2010
Mitochondria play a central role in the intrinsic pathway of apoptosis. Oligomerization of the mitochondrial protein VDAC1 (voltage-dependent anion channel 1) has been proposed to play a role in apoptosis in various studies. In the present study, we have generated dimeric fusion proteins consisting of tandem-linked wild-type and RuR (Ruthenium Red ...
Asaf, Mader, Salah, Abu-Hamad, Nir, Arbel, Manuel, Gutiérrez-Aguilar, Manuel, Gutierr-Asuilar, Varda, Shoshan-Barmatz   +5 more
openaire   +2 more sources

ANP32B promotes lung cancer progression by regulating VDAC1

Gene, 2023
It has been reported before that acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B) plays roles in many cancers, yet no report of its role in lung cancer exists. In this study, we documented an elevation of ANP32B within lung cancer tissues and cells. Knockdown of ANP32B hindered the proliferation as well as migration of lung cancer
Tiezhi, Li, Na, Wang, Shujun, Li, Hongjiang, Yan, Shaolin, Gao, Weinian, Gao, Ruoxuan, Xu   +6 more
openaire   +2 more sources

In silico construction of HK2-VDAC1 complex and investigating the HK2 binding-induced molecular gating mechanism of VDAC1

Mitochondrion, 2016
Hexokinase 2 (HK2) binds to Voltage-Dependent Anion Channel 1 (VDAC1) on mitochondrial outer membrane (MOM) to facilitate a preferential access of ATP to HK2 for glycolysis, in order to maintain a constant energy source for cell proliferation in cancer especially. While previous studies have discovered that the VDAC1 N-terminal helix is responsible for
Dawei, Zhang, Yew Mun, Yip, Liben, Li
openaire   +2 more sources

Purification of VDAC1 from Rat Liver Mitochondria

Cold Spring Harbor Protocols, 2013
To make biophysical measurements of functions such as the pore-forming activity of mitochondrial voltage-dependent anion-selective channel protein 1 (VDAC1), it is first necessary to obtain a source of purified VDAC protein. In this protocol, we present a method for obtaining rat liver mitochondria as a source of VDAC1 and then describe two methods ...
Danya, Ben-Hail, Varda, Shoshan-Barmatz
openaire   +2 more sources

VDAC1: at the crossroads of cancer signalling and metabolism

Expert Review of Proteomics
Mitochondrial membrane proteins are key regulators of mitochondrial physiology and function. Voltage-dependent anion channel 1 (VDAC1), also termed mitochondrial porin, regulates metabolite and ion exchange across the outer mitochondrial membrane. It governs mitochondrial bioenergetics, apoptotic signaling, redox balance, and intracellular calcium ...
Mahima Choudhari, Khushman Taunk, Bhargab Kalita, Srikanth Rapole   +3 more
openaire   +2 more sources

Characterization of VDAC1 as a plasma membrane NADH‐oxidoreductase

BioFactors, 2004
AbstractWe have recently demonstrated that voltage dependent anion selective channel 1 (porin, isoform 1) can function as a transplasma membrane NADH:ferricyanide‐reductase. However, both the specific redox characteristics and the mechanism of electron transport in this enzyme presently remain unclear.
Mark A, Baker, Jennifer D, Ly, Alfons, Lawen   +2 more
openaire   +2 more sources

Identification of VDAC1 as a cardioprotective target of Ginkgolide B

Chemico-Biological Interactions
Ginkgolide B (GB), a compound derived from Ginkgo biloba, exhibits significant cardioprotective properties, although its precise molecular target has yet to be identified. In this study, we synthesized a biotin-labeled GB probe (GB-biotin) to identify the molecular targets of GB.
Tingbiao Wu, Deyao Li, Qiuyu Chen, Dezhi Kong, Hongxuan Zhu, Hefeng Zhou, Qingwen Zhang, Guozhen Cui   +7 more
openaire   +2 more sources