Results 161 to 170 of about 10,788 (194)

Mitochondrial interplay with membrane organelles in health and disease. [PDF]

Cell Commun Signal
Liu SH, Wang Y, Tong C, Liu XM.
europepmc   +1 more source

A dual-action core-shell microneedle system restores mitochondrial function and accelerates healing in diabetic wounds. [PDF]

J Nanobiotechnology
Li X, Fu H, Yang C, Xu F, Li Y, Yang X, Shi Z, Zhang D, Li D, Zhang R.   +9 more
europepmc   +1 more source

Parkin Deficiency Impairs ER-Mitochondria Associations and calcium homeostasis via IP3R-Grp75-VDAC1 Complex. [PDF]

Int J Biol Sci
Xue NJ, Liu Y, Lin ZH, Huang WH, Zhang F, Zheng R, Si XL, Gu LY, Fan Y, Pu JL, Zhang BR.   +10 more
europepmc   +1 more source

Combined single-cell transcriptome and Mendelian randomization to identify and validate prognostic genes associated with endoplasmic reticulum stress and butyrate metabolism in lung adenocarcinoma. [PDF]

Front Genet
Li J, Shen F, Zha J, Zhou M, Yi N, Li K, Li Y.   +6 more
europepmc   +1 more source

VDAC1 at the Intersection of Cell Metabolism, Apoptosis, and Diseases

Biomolecules, 2020
The voltage-dependent anion channel 1 (VDAC1) protein, is an important regulator of mitochondrial function, and serves as a mitochondrial gatekeeper, with responsibility for cellular fate. In addition to control over energy sources and metabolism, the protein also regulates epigenomic elements and apoptosis via mediating the release of apoptotic ...
Varda Shoshan-Barmatz, Anna Shteinfer-Kuzmine, Shoshan-Barmatz Varda   +2 more
exaly   +6 more sources

VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria [PDF]

Cell Death and Differentiation, 2011
Voltage-dependent anion channels (VDACs) are expressed in three isoforms, with common channeling properties and different roles in cell survival. We show that VDAC1 silencing potentiates apoptotic challenges, whereas VDAC2 has the opposite effect. Although all three VDAC isoforms are equivalent in allowing mitochondrial Ca(2+) loading upon agonist ...
Diego De Stefani, A Bononi, Angela Messina   +2 more
exaly   +9 more sources

VDAC1-interacting anion transport inhibitors inhibit VDAC1 oligomerization and apoptosis

Biochimica Et Biophysica Acta - Molecular Cell Research, 2016
Mitochondria-mediated apoptosis involves pro-apoptotic protein release from the mitochondria to the cytosol, triggering apoptosis. However, the mechanisms by which apoptotic initiators cross the outer mitochondrial membrane (OMM) remain unclear. The voltage-dependent anion channel 1 (VDAC1), an OMM protein, is central to mitochondria-mediated apoptosis.
Danya Ben-Hail, Varda Shoshan-Barmatz
exaly   +3 more sources

Targeting the Mitochondrial Protein VDAC1 as a Potential Therapeutic Strategy in ALS

International Journal of Molecular Sciences, 2022
Impaired mitochondrial function has been proposed as a causative factor in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), caused by motor neuron degeneration. Mutations in superoxide dismutase (SOD1) cause ALS and SOD1 mutants
Anna Shteinfer-Kuzmine, Uttpal Anand, Ran Zalk   +2 more
exaly   +2 more sources

Preserving Insulin Secretion in Diabetes by Inhibiting VDAC1 Overexpression and Surface Translocation in β Cells [PDF]

Cell Metabolism, 2019
Type 2 diabetes (T2D) develops after years of prediabetes during which high glucose (glucotoxicity) impairs insulin secretion. We report that the ATP-conducting mitochondrial outer membrane voltage-dependent anion channel-1 (VDAC1) is upregulated in ...
Enming Zhang, Danya Ben-Hail, Yang De Marinis   +2 more
exaly   +2 more sources

VDAC1 as a Player in Mitochondria-Mediated Apoptosis and Target for Modulating Apoptosis

Current Medicinal Chemistry, 2018
Background: The voltage-dependent anion channel 1 (VDAC1), an outer mitochondria membrane protein, functions as a mitochondrial governor, controlling transport of metabolites in and out of the mitochondria and energy production, while also coordinating ...
Varda Shoshan-Barmatz, Yakov Krelin, Quan Chen   +2 more
exaly   +2 more sources