Results 181 to 190 of about 17,038 (231)

Inhibiting Glycolysis and Disrupting the Mitochondrial HK2-VDAC1 Protein-Protein Interaction Using a Bifunctional Lonidamine-Conjugated Metal Probe for Combating Triple-Negative Breast Cancer.

Journal of the American Chemical Society
Triple-negative breast cancer (TNBC) relies primarily on aerobic glycolysis for energy and rapid cancer cell proliferation. Hexokinase 2 (HK2), a key enzyme regulating glycolysis, is overexpressed in TNBC, promoting tumor cell proliferation and apoptosis
Ling Wang, Lingtan Kong, Ding-qi Zhang, Liuqi Ye, Sang-Cuo Nao, Daniel Shiu-Hin Chan, Xueying Li, Yu-tong Peng, Lijun Yang, Chun-Yuen Wong, V. K. Wong, Wanhe Wang, Hui Chao, Chung-Hang Leung   +13 more
semanticscholar   +1 more source

Astragaloside VI attenuates mechanical stress-induced cardiac remodeling through piezo1-VDAC1 dependent endoplasmic reticulum unfolded protein response.

Phytomedicine
BACKGROUND The dysregulation of protein homeostasis is a condition associated with mechanical stress-induced cardiac remodeling (CR) due to endoplasmic reticulum (ER) dysfunction and stress. PURPOSE This research explores the effect of Piezo1 on the ER
Shiyu Zhang, Wan-li Gao, Xiongyi Gao, Wenshi Xu, Yan Liu, Zhongxiu Guo, Guobin Liu, Pu Zhang, Hongshuo Shi, Xing Chang   +9 more
semanticscholar   +1 more source

VSTM2L protects prostate cancer cells against ferroptosis via inhibiting VDAC1 oligomerization and maintaining mitochondria homeostasis

Nature Communications
Ferroptosis is a form of iron-dependent programmed cell death, which is distinct from apoptosis, necrosis, and autophagy. Mitochondria play a critical role in initiating and amplifying ferroptosis in cancer cells. Voltage-Dependent Anion Channel 1 (VDAC1)
Juan Yang, Xiao Lu, Jing-Lan Hao, Lan Li, Yong-Tong Ruan, Xue-Ni An, Qilai Huang, Xiao-Ming Dong, Ping Gao   +8 more
semanticscholar   +1 more source

Sigma-1 receptor activation attenuates DOX-induced cardiotoxicity by alleviating endoplasmic reticulum stress and mitochondrial calcium overload via PERK and IP3R-VDAC1-MCU signaling pathways

Biology Direct
Doxorubicin (DOX) is an anthracycline with potent antitumor properties and rare yet serious cardiotoxic side effects that limit its clinical application.
Zixuan Li, Q. Ran, C. Qu, Shan Hu, Shengyu Cui, You Zhou, Bo Shen, Bo Yang   +7 more
semanticscholar   +1 more source

Dihydromyricetin regulates the miR-155-5p/SIRT1/VDAC1 pathway to promote liver regeneration and improve alcohol-induced liver injury.

Phytomedicine
BACKGROUND Alcohol-related liver disease (ALD) has become an increasingly serious global health issue. In recent years, growing evidence has highlighted the restoration of liver regenerative capacity as an effective therapeutic strategy for improving ALD.
Qing Ma, Shuo-Wen Huang, Mei Li, Qihan Luo, Fangming Chen, Chunlan Hong, Honghao Yan, Jiang Qiu, Kang-lu Zhao, Yu Du, Jinkai Zhao, Li-qin Zhou, Dayong Lou, Thomas Efferth, Changyu Li, Ping Qiu   +15 more
semanticscholar   +1 more source

Fatty acid synthesis promotes mtDNA release via ETS1-mediated oligomerization of VDAC1 facilitating endothelial dysfunction in sepsis-induced lung injury

Cell Death and Differentiation
Sepsis involves endothelial cell dysfunction leading to the development of lung injury. Fatty acid synthesis contributes to the development of inflammatory injury in sepsis.
Shiyuan He, T. Pan, Rui Tian, Qian He, Decui Cheng, Hongping Qu, Ranran Li, R. Tan   +7 more
semanticscholar   +1 more source

Membrane lipid composition modulates the organization of VDAC1, a mitochondrial gatekeeper

Communications Biology
VDACs, the most abundant proteins in the outer mitochondrial membrane (MOM), are crucial for mitochondrial physiology. VDAC regulate metabolite and ion exchange, modulate calcium homeostasis, and play roles in numerous cellular events such as apoptosis ...
Elodie Lafargue, J. Duneau, N. Buzhinsky, P. Ornelas, Alexandre Ortega, Varun Ravishankar, James N Sturgis, Ignacio Casuso, Lucie Bergdoll   +8 more
semanticscholar   +1 more source

Intranasal insulin administration affecting perioperative neurocognitive dysfunction by regulating calcium transport protein complex IP3R/GRP75/VDAC1 on MAMs.

Free Radical Biology & Medicine
Perioperative neurocognitive disorders (PND) are common complications following surgery and anesthesia, especially in the elderly. These disorders are associated with disruptions in neuronal energy metabolism and mitochondrial function.
Huiqing Liu, Yanhua Jiang, Li Cong, Xinyue Zhang, Yongjian Zhou, Xue Pan, Sidan Liu, Renyi Wang, Xuezhao Cao   +8 more
semanticscholar   +1 more source

Zishen Tongyang Huoxue decoction (TYHX) alleviates sinoatrial node cell ischemia/reperfusion injury by directing mitochondrial quality control via the VDAC1-β-tubulin signaling axis.

Journal of Ethnopharmacology, 2023
ETHNOPHARMACOLOGICAL RELEVANCE Zishen Tongyang Huoxue decoction (TYHX) has been used clinically for nearly 40 years to treat sick sinus syndrome. Previous reports showed that TYHX can inhibit calcium flux by regulating mitochondrial homeostasis via β ...
Xing Chang, Siyuan Zhou, Jinfeng Liu, Yanli Wang, Xuanke Guan, Qiaomin Wu, Qin Zhang, Zhiming Liu, Ruxiu Liu   +8 more
semanticscholar   +1 more source

VDAC1 Oligomerization-Mediated mtDNA Release under Sublethal Oxidative Stress: A Novel Inflammatory Mechanism in Vitiligo.

Free Radical Biology & Medicine
Oxidative stress is a critical initiating factor in vitiligo, yet the early molecular events linking redox imbalance to melanocyte immune activation remain unclear.
Rongyin Gao, Duo Meng, Zhilin Zhao, Hui Xue, Nan Hu, Peiwen Jiang, Wenhao Yu, Wenhui Xu, Chuanwei Yin, Huansha Zhang, Jinpeng Lv   +10 more
semanticscholar   +1 more source