Results 201 to 210 of about 17,038 (231)

VDAC1‐Targeted NHK1 Peptide Recovers Mitochondrial Dysfunction Counteracting Amyloid‐β Oligomers Toxicity in Alzheimer's Disease

Aging Cell
Mitochondrial dysfunction has been implicated in a broad range of age‐related pathologies and has been proposed as a causative factor in Alzheimer's disease (AD).
F. Cavallaro, Stefano Conti Nibali, S. M. Cubisino, Pietro Caruso, S. Zimbone, I. Infantino, S. Reina, V. De Pinto, Angela Messina, M. L. Giuffrida, Andrea Magrì   +10 more
semanticscholar   +1 more source

FMO2 Prevents Pathological Cardiac Hypertrophy by Maintaining the ER-Mitochondria Association Through Interaction With IP3R2-Grp75-VDAC1

Circulation
BACKGROUND: Cardiac hypertrophy, as an important pathological change, contributes to heart failure. Recent studies indicate that the mitochondria-associated endoplasmic reticulum membranes (MAMs) play key roles in this pathological process.
Changchen Xiao, Chao Wang, Jingyi Wang, Xianpeng Wu, Changle Ke, J. Nan, Hao Ding, Yinghui Xu, Yanna Shi, Jing Zhao, Cheng Ni, Qingnian Liu, Jiamin Li, Shuyuan Sheng, Hua Chen, Jiayue Cai, T. Zhao, Jinghai Chen, Qiming Sun, Bin Zhou, Jian’an Wang, Wei Zhu, Xinyang Hu   +22 more
semanticscholar   +1 more source

Koumine mediates the generation of mtROS through the IP3R1-GRP75-VDAC1 complex to improve Citrinin induced intestinal inflammation.

Phytomedicine
BACKGROUND Citrinin (CTN) is a mycotoxin that is difficult to eliminate and easy to ingest. Chronic exposure to CTN can lead to inflammatory bowel disease (IBD). The herb Koumine has strong anti-inflammatory activity and is considered a candidate for the
Yuanyuan Li, Xiaofang Liu, Qike Zhang, Zonghan Jiang, Weiqing Zhang, Chenglin Yang, Jie Ni, Si-Min Deng, J. Yi, Jing Wu, Zhiliang Sun, Zengenni Liang, Zhihang Yuan   +12 more
semanticscholar   +1 more source

Astragalin actives autophagy and inhibits apoptosis of astrocytes in AD mice via down-regulating Fas/Fasl-VDAC1 pathway.

Free Radical Biology & Medicine
Alzheimer's disease (AD) as a common neurodegenerative disease, which characterized by amyloid Aβ deposition and neurofibrillary tangles. Astragalin (AST), a natural flavonoid, has anti-inflammatory, antioxidant, anti-cancer, and other pharmacological ...
Shuhan Wang, YaQi Yang, Jiahong Lin, Weishan Zhang, Cuizhu Yang, Runheng Zhang, Chang Zhou, Li Zhang, Xin Wang, Jing Liu, Xiaobao Jin, Yuxin Ma   +11 more
semanticscholar   +1 more source

Liquiritigenin Alleviates Inflammation and Mitochondrial Dysfunction in Acute Pancreatitis via ERβ-VDAC1 Signaling.

Journal of Ethnopharmacology
ETHNOPHARMACOLOGICAL RELEVANCE Liquorice (Gancao), a classic Chinese herb, has been historically prescribed for inflammation and gastrointestinal disorders.
Yi-fan Miao, D. Bai, Shuhan Fan, Hong-Ying Li, Jia-Qi Yao, Jun-Feng Mo, Yong Chen, Wei Jin, Yun Lu   +8 more
semanticscholar   +1 more source

Neuroprotective effect of Urolithin A via downregulating VDAC1-mediated autophagy in Alzheimer's disease.

Acta Histochemica
BACKGROUND Amyloid β (Aβ) accumulation in the brains of patients with Alzheimer's disease (AD) contributes to cognitive impairment and neuronal damage. Urolithin A (UA), a gut microbiota-derived metabolite of ellagic acid, has been reported to cross the ...
Bensi Zhang, Xiujun Zhang, Waleephan Treebupachatsakul, Rungusa Pantan, Natnicha Kampan, M. Phatsara, C. Shi, Suteera Narakornsak   +7 more
semanticscholar   +1 more source

VDAC1 as Janus in cell death and survival: Annexin A5 to the rescue.

Cell Calcium
VDAC1, a large conductance channel in the outer mitochondrial membrane, plays a crucial role in mitochondrial physiology. VDAC1 supports cellular metabolism and survival by serving as a mitochondrial Ca2+-uptake and ATP-exit system.
Ophélie Champion, Jacek J Litewka, Pawel E. Ferdek, G. Bultynck   +3 more
semanticscholar   +1 more source

Harpagide from Radix Scrophulariae Attenuated Ischemic Stroke Injury Through Calcium Homeostasis Regulation Between Mitochondria-Associated Membranes via the IP3R1/GRP75/VDAC1 Complex.

Journal of Ethnopharmacology
ETHNOPHARMACOLOGICAL RELEVANCE Numerous studies have provided evidence supporting the significant roles of Radix Scrophulariae in the treatment of fevers, bacterial infection and encephalopathy.
Ke Wang, Yue Wang, Huaiyang Liu, G. Su, Yuan-yuan Dong, Yue Chen, Yan-ping Wang, Zhi He   +7 more
semanticscholar   +1 more source

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Nature Cell Biology, 2010
Sven Geisler, Kira M. Holmström, Diana Skujat, F. Fiesel, Oliver C. Rothfuss, P. Kahle, W. Springer   +6 more
semanticscholar   +1 more source

Hexokinase-I directly binds to a charged membrane-buried glutamate of mitochondrial VDAC1 and VDAC2

bioRxiv
Binding of hexokinase HKI to mitochondrial voltage-dependent anion channels (VDACs) has far-reaching physiological implications. However, the structural basis of this interaction is unclear.
Sebastian Bieker, Michael Timme, Nils Woge, D. G. Hassan, Chelsea M. Brown, Siewert J. Marrink, Manuel N. Melo, J. Holthuis   +7 more
semanticscholar   +1 more source