Results 91 to 100 of about 2,059,233 (272)

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

The TUBA1B–G3BP2 Axis Sustains p65 Transcriptional Activity to Promote Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
TUBA1B is consistently upregulated in hepatocellular carcinoma and sustains malignant progression by stabilizing G3BP2. By restraining TRIM25‐associated K48‐linked ubiquitination, TUBA1B preserves the G3BP2–IκBα complex and basal NF‐κB/p65 activity. Concurrent TUBA1B/G3BP2 upregulation identifies an aggressive HCC subgroup with enhanced p65 activation ...
Fen Lin, Hechun Lin, Junming Yu, Chao Ge, Lin Mao, Saihua Zhang, Yizi Jin, Yunyu Wu, Taoyang Chen, Jinjun Li, Hong Li   +10 more
wiley   +1 more source

Skin models for studying vector-borne kinetoplastid infections

Current Opinion in Microbiology
Kinetoplastid infections, caused by Leishmania and Trypanosoma species, pose significant global health challenges, disproportionally affecting vulnerable populations in tropical regions. Despite the skin's pivotal role as both an entry point and a reservoir for these parasites, the mechanistic understanding of host-parasite interactions at this ...
Laura Hauf, Markus Engstler
openaire   +2 more sources

Epidemiological Situation on Vector-Borne Natural-Focal Infections in the Territory of Caucasian Mineral Waters

Проблемы особо опасных инфекций, 2014
Represented is the analysis of epidemiological situation on vector-borne natural-focal infections in the specially protected eco-resort territory of Russia - Caucasian Mineral Waters of the Stavropol Region.
N. F. Vasilenko, A. V. Ermakov, O. V. Maletskaya, A. N. Kulichenko   +3 more
doaj   +1 more source

Case report: Substantial improvement of autism spectrum disorder in a child with learning disabilities in conjunction with treatment for poly-microbial vector borne infections. [PDF]

Front Psychiatry, 2023
Offutt A, Breitschwerdt EB.
europepmc   +1 more source

m5C Reader ALYREF Promotes the Progression of Endometrial Cancer by Activating the XRCC6‐Mediated Wnt/β‐catenin Signaling Pathway

Advanced Science, EarlyView.
This study identifies ALYREF as an oncogenic m5C reader in endometrial cancer. ALYREF recognizes NSUN2‐mediated m5C modification on XRCC6 mRNA to enhance transcript stability and increase XRCC6 expression. Elevated XRCC6 activates Wnt/β‐catenin signaling, resulting in accelerated tumor cell proliferation, migration, invasion, and xenograft tumor growth.
Linlin Hao, Jian Zhang, Qi Qian, Min Jiang, Yu Liu, Yan Geng, Nan Cui, Qi Guo, Jie Guo   +8 more
wiley   +1 more source

WNV infection - an emergent vector borne viral infection in Serbia: Current situation

Veterinarski glasnik, 2015
West Nile virus (WNV) is a neurovirulent mosquito-borne Flavivirus with zoonotic potential. Virus is maintained in nature in an enzootic transmission cycle between avian hosts and mosquito vectors, but occasionally infects other vertebrates.
Tamas Petrovic, Diana Lupulovic, Dusan Petric, Ana Vasic, Ivana Hrnjakovic-Cvjetkovic, Vesna Milosevic, Dejan Vidanovic, Milanko Sekler, Sava Lazic, Bosiljka Djuricic, Budimir Plavsic, Juan-Carlos Saiz   +11 more
openaire   +3 more sources

Human tick biting and tick-borne disease risk in Türkiye: Systematic review.

PLoS Neglected Tropical Diseases
Ticks serve as significant vectors for over 100 pathogens, many of which pose serious health risks to humans. Türkiye's diverse tick species and ideal ecological conditions facilitate their proliferation.
Salar Zarrabi Ahrabi, Fatihan Pınarlık, Gürkan Akyıldız, Mert Kuşkucu, Sırrı Kar, Önder Ergönül, Ayşen Gargılı Keleş, TEH Vector-Borne Infections Study Group   +7 more
doaj   +1 more source

Chronological change in the incidence risk levels of mosquito-borne and rodent-borne infections

International Journal of Infectious Diseases
Introduction: We examined the change over time in the incidence risk levels of mosquito-borne and rodent-borne infections. Methods: We used the data of “Summary of risk assessment of vector-borne disease at Japanese Quarantine ports and airports ...
Dr Soichi Takeishi, Dr Tatsuo Inoue, Dr Koichi Miyamura   +2 more
doaj   +1 more source

Haematological Alterations Associated with Selected Vector-Borne Infections and Exposure in Dogs from Pereira, Risaralda, Colombia. [PDF]

Animals (Basel), 2022
Bonilla-Aldana DK, Gutiérrez-Grajales EJ, Osorio-Navia D, Chacón-Peña M, Trejos-Mendoza AE, Pérez-Vargas S, Valencia-Mejía L, Marín-Arboleda LF, Martínez-Hidalgo JP, Reina-Mora MA, González-Colonia LV, Cardona-Ospina JA, Jiménez-Posada EV, Diaz-Guio DA, Salazar JC, Sierra M, Muñoz-Lara F, Zambrano LI, Ramírez-Vallejo E, Álvarez JC, Jaramillo-Delgado IL, Pecho-Silva S, Paniz-Mondolfi A, Faccini-Martínez ÁA, Rodríguez-Morales AJ.   +24 more
europepmc   +1 more source