Results 91 to 100 of about 1,916,755 (267)

Prevalence of Borrelia miyamotoi and Neoehrlichia mikurensis in a cohort of tick-exposed individuals and population controls in Denmark 2002–2021

Ticks and Tick-Borne Diseases
Borrelia miyamotoi and Neoehrlichia mikurensis are recently discovered tick-borne pathogens. The aim of this study was to ascertain the extent of transmission among high-risk groups and healthy controls.The study design is retrospective cohort study ...
Helene Mens, Rosa Gynthersen, Nanna Skaarup Andersen, Mathilde Ørbæk, Fredrikke C. Knudtzen, Sanne Løkkegaard Larsen, Sigurdur Skarphedinsson, Olga A. Stukolova, Dieuwertje Hoornstra, Joppe W. Hovius, Anne-Mette Lebech   +10 more
doaj   +1 more source

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

Acute Vector-Borne Viral Infection: Zika and MinION Surveillance

Microbiology Spectrum, 2019
ABSTRACTThe MinION sequencer was launched by the Oxford Nanopore Technologies start-up as a disruptive technology for genome sequencing based on single-molecule synthesis. Its characteristics as a portable device, low cost, and simple library preparation have made it a good candidate for field researchers.
Jaqueline Goes, de Jesus, Marta, Giovanetti, Nuno, Rodrigues Faria, Luiz Carlos Junior, Alcantara   +3 more
openaire   +2 more sources

REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma

Advanced Science, EarlyView.
Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu, Shihui Shen, Dongxia Li, Peilin Shi, Jiaming Xu, Tongxin Lv, Yingying Du, Jingwei Zhang, Bo Yang, Hansen Chen, Zhuoya Peng, Wenjie Ren, Lu Zhang, Sheng Cheng, Tongjin Yin, Wencai Sheng, Lei Li, Juan Wu, Qingcheng Yang, Shuogui Xu, Wei Zheng   +20 more
wiley   +1 more source

Contributions of ENDOBACT multicentric study to the infective endocarditis etiology in Romania

Romanian Journal of Laboratory Medicine, 2013
Studiul multicentric ENDOBACT a avut ca scop implementarea metodelor moleculare de identificare a speciilor bacteriene implicate in endocardita infecţioasă, precum şi încercarea de a diminua numărul cazurilor cu etiologie neprecizată.
Oprea Mihaela, Surdeanu Maria, Badescu Daniela, Cotar Ani Ioana, Dinu Sorin, Banu Otilia, Flonta Mirela, Straut Monica   +7 more
doaj   +1 more source

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, EarlyView.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source

Cockroaches and Food-borne Pathogens

Environmental Health Insights, 2020
Food-borne disease is a widespread and escalating public health problem globally. About a quarter of the microorganisms isolated from cockroaches are food-borne pathogens including Escherichia coli O157:H7, Staphylococcus aureus, Bacillus cereus ...
Eric S Donkor
doaj   +1 more source

Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Advanced Science, EarlyView.
Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta, Shuyi Wang, Boyan Zhang, Ning Liu, Yingchen Han, Aoran Liu, Ying Xu, Tingsong Chen, Ye Zhang, Qiuhua Luo, Tao Han   +10 more
wiley   +1 more source

WNV infection - an emergent vector borne viral infection in Serbia: Current situation

Veterinarski glasnik, 2015
West Nile virus (WNV) is a neurovirulent mosquito-borne Flavivirus with zoonotic potential. Virus is maintained in nature in an enzootic transmission cycle between avian hosts and mosquito vectors, but occasionally infects other vertebrates.
Tamas Petrovic, Diana Lupulovic, Dusan Petric, Ana Vasic, Ivana Hrnjakovic-Cvjetkovic, Vesna Milosevic, Dejan Vidanovic, Milanko Sekler, Sava Lazic, Bosiljka Djuricic, Budimir Plavsic, Juan-Carlos Saiz   +11 more
openaire   +3 more sources

Single‐cell Transcriptome Profiling Reveals Gene Regulatory Networks and Key Genes in the Root Epidermis and Cortical Cells Associated with Early Nodulation in Glycine Max

Advanced Science, EarlyView.
Single‐cell transcriptomics of soybean roots soon after rhizobial inoculation reveals epidermal and cortical cell‐specific programs and gene‐regulatory networks acting in symbiosis establishment. We identify an ethylene‐driven regulatory circuit involving WRKY6.3/6.4 transcription factors targeting select Nod19 genes that promotes infection‐thread ...
Yongbin Zhuang, Yu Geng, Xinyu Guo, Chen Wang, Yongjing Sun, Luqi Liu, Li Liu, QianQian Gao, XinFang Zhu, Hongxiang Cao, Gengshuo Zhang, Yunxia Liu, Guobin Zhang, Baoyin Chen, Jinfei Zhang, Xin Hou, Xiaoming Li, Dajian Zhang   +17 more
wiley   +1 more source