Results 81 to 90 of about 164,296 (306)

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

Advanced Biology, EarlyView.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li, Sepehr Akhtarkhavari, Sumeng Qi, Jiawei Fan, Tu‐Yung Chang, Yao‐An Shen, JinMing Yang, Barbara S. Slusher, Ie‐Ming Shih, Stephanie Gaillard, Tian‐Li Wang   +10 more
wiley   +1 more source

Acceptability of 4-poster deer treatment devices for community-wide tick control among residents of high Lyme disease incidence counties in Connecticut and New York, USA

Ticks and Tick-Borne Diseases, 2023
The 4-Poster Tick Control Deer Feeder (4-poster) device applies acaricide to white-tailed deer (Odocoileus virginianus) and can reduce populations of the blacklegged tick (Ixodes scapularis), which transmits the agents of Lyme disease, anaplasmosis ...
Courtney C. Nawrocki, Nicholas Piedmonte, Sara A. Niesobecki, Adam Rowe, AmberJean P. Hansen, Alison Kaufman, Erik Foster, James I. Meek, Linda Niccolai, Jennifer White, Bryon Backenson, Lars Eisen, Sarah A. Hook, Neeta P. Connally, Victoria L. Hornbostel, Alison F. Hinckley   +15 more
doaj  

Integrated Mapping of Establishment Risk for Emerging Vector-Borne Infections: A Case Study of Canine Leishmaniasis in Southwest France

PLoS ONE, 2011
Background Zoonotic visceral leishmaniasis is endemic in the Mediterranean Basin, where the dog is the main reservoir host. The disease's causative agent, Leishmania infantum, is transmitted by blood-feeding female sandflies.
N. Hartemink, S. Vanwambeke, H. Heesterbeek, David Rogers, D. Morley, B. Pesson, C. Davies, S. Mahamdallie, P. Ready   +8 more
semanticscholar   +1 more source

3D Bioprinting of Thick Adipose Tissues with Integrated Vascular Hierarchies

Advanced Functional Materials, Volume 35, Issue 12, March 18, 2025.
An advanced 3D bioprinting technique is used here to create thick adipose tissues with a central, vessel and extensive branching. The construct is made using alginate, gelatin and collagen‐based bioinks. Flow through the complex vessel network is demonstrated as well as its successful integration with a femoral artery following implantation in a rat ...
Idit Goldfracht, Majd Machour, Inbal Michael, Maria Bulatova, Janette Zavin, Shulamit Levenberg   +5 more
wiley   +1 more source

Improved antibody breadth with an extended primary dose interval of COVID-19 vaccine is overcome by boosters

Frontiers in Immunology
IntroductionDuring rollout of mRNA-based COVID-19 vaccines, several jurisdictions extended the interval between the first and second doses to prioritize wider population access to limited vaccine supply.
Jessica I. Ahmed, Samantha J. Krosta, Mandy N. Reimer, Winnie Cheung, Christine Mesa, Carmen Lopez, Rayeil J. Chua, Farah Alsattari, Alyssia Robinson, Kathy Manguiat, Naima Jahan, Bernard Abrenica, Angela Harris, Karla Cachero, Rissa Fabia, Jonathan Walker, Myo Minn Oo, Derek Stein, Derek Stein, Hezhao Ji, Hezhao Ji, Ruey-Chyi Su, Ruey-Chyi Su, Paul J. McLaren, Paul J. McLaren, Lyle R. McKinnon, Lyle R. McKinnon, Lyle R. McKinnon, T Blake Ball, T Blake Ball, Heidi Wood, John Kim, Sandra A. Kiazyk, Sandra A. Kiazyk, Catherine M. Card, Catherine M. Card   +35 more
doaj   +1 more source

Characteristics of extreme increase of vector-borne infections in the european north

, 2014
Aim. To describe clinical and epidemiological situation of the massive increase of cases of vector-borne infections and the level of preventive and antiepidemic measures in the Archangelsk region over the last decade. Methods. Retrospective, longitudinal
I. Burmagina, V. Agafonov, D. V. Burmagin   +2 more
semanticscholar   +1 more source

Strategies to Design and Optimize Artificial Antigen‐Presenting Cells for T Cell Expansion in Cancer Immunotherapy

Advanced Functional Materials, EarlyView.
This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

The role of companion animals in the environmental circulation of tick-borne bacterial pathogens

Annals of Agricultural and Environmental Medicine, 2018
Ticks are known as vectors of a wide range of pathogens of medical and veterinary importance; some of them of zoonotic concern constitute a hazard for the emergence of tick-borne diseases shared between humans and domestic animals and becoming a part of ...
Bogumiła Skotarczak
doaj   +1 more source

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Advanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla, Vincenzo Verdi, Willemijn de Voogt, Mariona Estapé Sentí, Arnold C. Koekman, Julian Rietveld, Sven van Kempen, Qiangbing Yang, Juliette van Merris, Guido Jenster, Martin E. van Royen, Marcel H. Fens, Sander A. A. Kooijmans, Wytske M. van Weerden, Guillaume van Niel, Pieter Vader, Raymond M. Schiffelers   +16 more
wiley   +1 more source