Results 11 to 20 of about 345,542 (292)
Exploring the Intracrine Functions of VEGF-A [PDF]
Biomolecules, 2021 Vascular endothelial growth factor A (VEGF-A or VEGF) is a highly conserved secreted signalling protein best known for its roles in vascular development and angiogenesis.
Sophie Wiszniak, Quenten Schwarz
doaj +4 more sources
Circulating levels of anti-angiogenic VEGF-A isoform (VEGF-Axxxb) in colorectal cancer patients predicts tumour VEGF-A ratios [PDF]
American journal of cancer research, 2015 Purpose: Bevacizumab as an adjunct to chemotherapy improves survival for some patients with metastatic colorectal cancer. Immunohistochemical staining of samples from the registration ECOG E3200 trial of bevacizumab with FOLFOX demonstrated that only ...
Bates, David O +7 more
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N-VEGF, the autoregulatory arm of VEGF-A [PDF]
Cells, 2021 Vascular endothelial growth factor A (VEGF-A) is a secreted protein that stimulates angiogenesis in response to hypoxia. Under hypoxic conditions, a non-canonical long isoform called L-VEGF is concomitantly expressed with VEGF-A. Once translated, L-VEGF it is proteolytically cleaved to generate N-VEGF and VEGF-A. Interestingly, while VEGF-A is secreted
Marina Katsman +4 more
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VEGF-A in Cardiomyocytes and Heart Diseases [PDF]
International Journal of Molecular Sciences, 2020 The vascular endothelial growth factor (VEGF), a homodimeric vasoactive glycoprotein, is the key mediator of angiogenesis. Angiogenesis, the formation of new blood vessels, is responsible for a wide variety of physio/pathological processes, including cardiovascular diseases (CVD).
Braile M. +8 more
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Expression of functional eGFP-fused antigen-binding fragment of ranibizumab in Pichia pastoris [PDF]
BioImpacts, 2022 Introduction: Ranibizumab is a mouse monoclonal antibody fragment antigen-binding (Fab) against human vascular endothelial growth factor-A (VEGF-A), inhibiting angiogenesis.
Shirin Movaghar Asareh +6 more
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VEGF: a critical player in neurodegeneration [PDF]
Journal of Clinical Investigation, 2004 VEGF is a prototype angiogenic factor, but recent evidence indicates that this growth factor also has direct effects on neural cells. Abnormal regulation of VEGF expression has now been implicated in several neurodegenerative disorders, including motoneuron degeneration.
Erik, Storkebaum, Peter, Carmeliet
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Association of VEGF cytokine levels and single nucleotide polymorphisms of the VEGF-A gene with the genital endometriosis in the female population of the Northwestern Federal District of Russia [PDF]
Гинекология, 2022 Aim. To study the association of neoangiogenesis VEGF-A gene polymorphisms C(-460)T (rs833061), C(+936)T (rs3025039) with the risk of genital endometriosis in the population of the Northwestern Federal District; to examine the relationship of polymorphic
Natalia V. Kulikova +3 more
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Zaporožskij Medicinskij Žurnal, 2022 Extracellular small vesicles – exosomes, attract the attention of researchers as a promising tool for regulating intercellular communication. At the same time, the therapeutic effects achieved through the use of mesenchymal stem cells (MSCs) are ...
L. V. Natrus +6 more
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VEGF-A related SNPs: a cardiovascular context
Frontiers in Cardiovascular Medicine, 2023 Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Currently, cardiovascular disease risk algorithms play a role in primary prevention. However, this is complicated by a lack of powerfully predictive biomarkers that could be observed in individuals before the onset of overt symptoms.
Meza-Alvarado JC +4 more
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Positive and negative regulation of angiogenesis by soluble vascular endothelial growth factor receptor-1 [PDF]
, 2018 Vascular endothelial growth factor receptor (VEGFR)-1 exists in different forms, derived from alternative splicing of the same gene. In addition to the transmembrane form, endothelial cells produce a soluble VEGFR-1 (sVEGFR-1) isoform, whereas non ...
Carbo, Miriam +2 more
core +6 more sources