VEGF family members : modulators of tumor angiogenesis and lymphangiogenesis [PDF]
Members of the vascular endothelial growth factor (VEGF) family and their receptors (VEGFR) play an essential role in the development and maintenance of the blood and lymphatic vasculature.
Kopfstein, Lucie
core +1 more source
Mechanisms of vascular morphogenesis and stabilization by VEGF dose [PDF]
VEGF is the master regulator of angiogenesis and the most investigated factor in therapeutic angiogenesis approaches to induce the growth of new vessels that could restore oxygen and nutrients supply in tissues affected by ischemia.
Groppa, Elena
core +1 more source
Clinical significance of VEGF-A, -C and -D expression in esophageal malignancies [PDF]
Vascular endothelial growth factors ( VEGF)- A, - C and - D are members of the proangiogenic VEGF family of glycoproteins. VEGF-A is known to be the most important angiogenic factor under physiological and pathological conditions, while VEGF-C and VEGF-D
Jauch, Karl-Walter +2 more
core +1 more source
VEGF(164)-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization [PDF]
Hypoxia-induced VEGF governs both physiological retinal vascular development and pathological retinal neovascularization. In the current paper, the mechanisms of physiological and pathological neovascularization are compared and contrasted.
Ogura, Y +44 more
core +1 more source
VEGF-A, VEGF-C, and VEGF-D in Colorectal Cancer Progression
We aimed to assess the relationship of the angiogenic cytokines VEGF-A, VEGF-C, and VEGF-D and their receptors VEGFR-2 and VEGFR-3 in the adenoma-carcinoma sequence and in metastatic spread of colorectal cancer (CRC). mRNA expression levels were measured using semi-quantitative reverse transcription polymerase chain reaction in 70 CRC (35 with paired ...
Mark L. George +6 more
openaire +3 more sources
VEGF in the Nervous System [PDF]
Vascular endothelial growth factor (VEGF, VEGFA) is critical for blood vessel growth in the developing and adult nervous system of vertebrates. Several recent studies demonstrate that VEGF also promotes neurogenesis, neuronal patterning, neuroprotection and glial growth.
Jeffrey M, Rosenstein +2 more
openaire +2 more sources
Tumour cells expressing single VEGF isoforms display distinct growth, survival and migration characteristics [PDF]
Vascular endothelial growth factor-A (VEGF) is produced by most cancer cells as multiple isoforms, which display distinct biological activities. VEGF plays an undisputed role in tumour growth, vascularisation and metastasis; nevertheless the functions of
Reyes-Aldasoro, Constantino C. +61 more
core +2 more sources
The significance of some growth factors in the pathogenesis of endocrine ophthalmopathy
Aim. The purpose of this work was to study the role of transforming growth factors (TGF-, FGF-2, VEGF-A) during endocrine ophthalmopathy (EOC). Materials and methods. The study 119 patients with endocrine ophthalmopathy were examined, at the age of 48
Vladimir V. Charinzev +3 more
doaj +1 more source
Regulatory Role of microRNAs in Tumor Angiogenesis
The process of neoangiogenesis is one of the classic hallmarks of a cancer. Its intricate mechanisms have long been one of the major domains in cancer research and a hope for a therapeutic breakthrough.
Popov T. +7 more
doaj +1 more source
Brain homeostasis : VEGF receptor 1 and 2 ; two unequal brothers in mind [PDF]
Vascular endothelial growth factors (VEGFs), initially thought to act specifically on the vascular system, exert trophic effects on neural cells during development and adulthood.
Karl H. Plate +5 more
core +1 more source

