Results 41 to 50 of about 316,152 (254)

The Role of VEGF and VEGF Receptors in Carcinogenesis [PDF]

Journal of Carcinogenesis & Mutagenesis, 2012
The vascular endothelial growth factor (VEGF) family and its associated cognate receptors are critical components of angiogenesis, the process of new blood vessel formation. Under normal conditions, angiogenesis supports organism development and tissue homeostasis in a tightly controlled fashion.
openaire   +1 more source

Vascular endothelial growth factor attenuates enhanced spontaneous transdifferentiation of classical and intermediate monocytes in patients with ischemic cardiomyopathy

Сеченовский вестник
Aim. To evaluate the effect of vascular endothelial growth factor A (VEGF-A) on the subpopulation composition of monocytes in the blood mononuclear cell culture of patients with coronary heart disease (CHD), with and without ischemic cardiomyopathy (ICMP)
M. V. Gladkovskaya, S. P. Chumakova, O. I. Urazova, V. S. Poletika, V. M. Shipulin, S. L. Andreev   +5 more
doaj   +1 more source

Neuroprotective Effects of VEGF-A Nanofiber Membrane and FAAH Inhibitor URB597 Against Oxygen–Glucose Deprivation-Induced Ischemic Neuronal Injury

International Journal of Nanomedicine, 2021
Da-Peng Wang,1 Kai-Yan Jin,1 Peng Zhao,2 Qi Lin,3 Kai Kang,4 Jian Hai1 1Department of Neurosurgery, Tong Ji Hospital, Tong Ji University School of Medicine, Shanghai, 200065, People’s Republic of China; 2Institute for Translational Medicine ...
Wang DP, Jin KY, Zhao P, Lin Q, Kang K, Hai J   +5 more
doaj  

Comparative analysis of diagnostic significance of biomarkers’ panels in cardiac recipients in the long term period after transplantation

Вестник трансплантологии и искусственных органов, 2017
Aim. To perform comparative analysis of the diagnostic efficacy of sCD40L, PDGF-BB, VEGF-A and ST2 in recipients with cardiac rejection in different periods after transplantation. Materials and methods. The study included 144 cardiac recipients aged from
O. P. Shevchenko, A. V. Aksyonova, А. А. Ulybysheva, N. P. Mozheiko, E. A. Nikitina, V. I. Orlov, E. A. Stakhanova, А. О. Shevchenko   +7 more
doaj   +1 more source

VASCULAR ENDOTHELIAL GROWTH FACTORS IN HEART TRANSPLANT REJECTIONS

Вестник трансплантологии и искусственных органов, 2015
Aim: to determine the clinical significance of vascular endothelial growth factors VEGF-A, VEGF-D, PlGF-1 to assess the risk of cardiovascular complications in heart recipients. Materials and methods.
O. P. Shevchenko, E. A. Stakhanova, A. O. Shevchenko, N. P. Mogeiko, O. E. Gichkun   +4 more
doaj   +1 more source

Utilization of a chicken embryo membrane model for evaluation of embryonic vascular toxicity of Dorema ammoniacum [PDF]

Avicenna Journal of Phytomedicine, 2020
Objective: Extensive research has been done to assess the efficacy of herbs for treating different disorders. Dorema ammoniacum (D. ammoniacum) is used in folk medicines for various goals.
Hadi Tavakkoli, Amin Derakhshanfar, Javad Moayedi, Ali Poostforoosh Fard   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source