Results 71 to 80 of about 345,542 (292)

Long-Term Intravitreal Ranibizumab as a Potential Additional Risk Factor for Neurodegeneration in Parkinson's Disease: A Case Report. [PDF]

, 2018
In November 2012, a 72-year old patient was diagnosed with left eye wet age-related macular degeneration. The patient received three monthly intravitreal injections of ranibizumab, with complete resolution of retinal hemorrhage and edema and ...
Antonini, Bodis-Wollner, Brilliant, Brown, Chung, Cutroneo, de Jong, Ding, Drake, Enders, Falk, Gibson, Kemp, Krum, Miners, Naranjo, Nowacka, Nowacka, Piltonen, Pitzer, Poewe, Postuma, Pratt, Quittet, Rosenfeld, Shamloo, Sheikh, Silverman, Slotnick, Stewart, Storkebaum, Tian, Trost, Ueta, Whitton, Wu, Yasuda, Yasuhara, Yasuhara, Yasuhara, Yla-Herttuala, Yue, Zachary, Zehetner   +43 more
core   +2 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Glucocerebroside reduces endothelial progenitor cell-induced angiogenesis

Food and Agricultural Immunology, 2019
The recruitment of bone marrow-derived endothelial progenitor cells (EPCs) facilitates physiological and pathological processes involved in new blood vessel synthesis.
Hsiang-Ping Lee, Shih-Wei Wang, Yang-Chang Wu, Chang-Hai Tsai, Fuu-Jen Tsai, Jing-Gung Chung, Chih-Yang Huang, Jai-Sing Yang, Yuan-Man Hsu, Mei-Chin Yin, Te-Mao Li, Chih-Hsin Tang   +11 more
doaj   +1 more source

Simulations demonstrate a simple network to be sufficient to control branch point selection, smooth muscle and vasculature formation during lung branching morphogenesis [PDF]

, 2012
Proper lung functioning requires not only a correct structure of the conducting airway tree, but also the simultaneous development of smooth muscles and vasculature.
Cellière, Géraldine, Iber, Dagmar, Menshykau, Denis   +2 more
core   +3 more sources

VEGF-A-related genetic variants protect against Alzheimer’s disease

Aging, 2022
The Apolipoprotein E (APOE) genotype has been shown to be the strongest genetic risk factor for Alzheimer's disease (AD). Moreover, both the lipolysis-stimulated lipoprotein receptor (LSR) and the vascular endothelial growth factor A (VEGF-A) are involved in the development of AD.
Petrelis, Alexandros, Stathopoulou, Maria, Kafyra, Maria, Murray, Helena, Masson, Christine, Lamont, John, Fitzgerald, Peter, Dedoussis, George, Yen, Frances, Visvikis-Siest, Sophie   +9 more
openaire   +4 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Inhibition of MAPK-Erk pathway in vivo attenuates aortic valve disease processes in Emilin1-deficient mouse model [PDF]

, 2017
Aortic valve disease (AVD) is a common condition with a progressive natural history, and presently, there are no pharmacologic treatment strategies. Elastic fiber fragmentation (EFF) is a hallmark of AVD, and increasing evidence implicates developmental ...
Aikawa, Barnette, Basalyga, Bonow, Brown-Augsburger, Brunskill, Brunskill, Chung, Fondard, Franco, Gallegos, Gapski, Ghosh, Gu, Helske, Hinton, Hinton, Holm, Ihn, Iverson, Jensen, Keane, Krenz, Liang, Lindeman, Marshall, Mercer, Mohler, Mozaffarian, Munjal, Nishimura, Nkomo, Perrotta, Poggio, Potter, Rajamannan, Rossebo, Sauls, Schmieder, Schoen, Starcher, Vesely, Wirrig, Wylie-Sears, Xiong, Xiong   +45 more
core   +2 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

VEGF-A isoforms differentially regulate ATF-2-dependent VCAM-1 gene expression and endothelial-leukocyte interactions [PDF]

, 2014
Vascular endothelial growth factor A (VEGF-A) regulates many aspects of vascular physiology. VEGF-A stimulates signal transduction pathways that modulate endothelial outputs such as cell migration, proliferation, tubulogenesis, and cell-cell interactions.
Abid MR, Abid MR, Adam F. Odell, Alexander F. Bruns, Antony M. Latham, Arthur JS, Baker M, Bartoli M, Bates DO, Bruns AF, Bruns AF, Butler JM, Carl-Henrik Heldin, Carmeliet P, Chen TT, Chung AS, Collins T, Cuhlmann S, Dejana E, Delcombel R, Ding BS, Ewan LC, Fearnley GW, Gareth W. Fearnley, Gerits N, Goddard LM, Griffioen AW, Harper SJ, Herve MA, Holmqvist K, Hordijk PL, Horowitz A, Howell GJ, Ian C. Zachary, Jain RK, Jopling HM, Jopling HM, Karihaloo A, Kawasaki H, Kawasaki H, Keyt BA, Kim I, Kim I, Koch S, Koch S, Lau E, Lemmon MA, Liu D, Meadows KL, Melder RJ, Monica C. Hollstein, Nadeem A. Mughal, Nakatsu MN, Nakayama M, Naldini A, Nicholas J. Burgoyne, Nourshargh S, Pan Q, Panne D, Plotnikov A, Reglero-Real N, Reimold AM, Rivera CG, Salameh A, Schweighofer B, Seko Y, Shalaby F, Shervanthi Homer-Vanniasinkam, Sixt M, Sreenivasan Ponnambalam, Stannard AK, Stephen B. Wheatcroft, Takahashi T, Testori J, Usui T, Weber C, Xu D, Zhang HT, Zhang Y   +78 more
core   +3 more sources

Nuclear translocation of cGAS orchestrates VEGF-A-mediated angiogenesis

Cell Reports, 2023
Cyclic GMP-AMP synthase (cGAS) senses cytosolic incoming DNA and consequently activates stimulator of interferon response cGAMP interactor 1 (STING) to mount immune response. Here, we show nuclear cGAS could regulate VEGF-A-mediated angiogenesis in an immune-independent manner. We found VEGF-A stimulation induces cGAS nuclear translocation via importin-
Juanjuan Luo, Chunjiao Lu, Yang Chen, Xuewei Wu, Chenchen Zhu, Wei Cui, Shicang Yu, Ningning Li, Yihang Pan, Weijiang Zhao, Qingkai Yang, Xiaojun Yang   +11 more
openaire   +3 more sources