Results 81 to 90 of about 345,542 (292)

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Investigation of the Effect of High-Intensity Interval Training (HIIT) on the Expression of the Genes miR-126, miR-296, HGS and VEGF-A Protein Levels in Tumor Tissue in Female Mice [PDF]

Journal of Advanced Biomedical Sciences, 2021
Background & Objective: The studies of the last two decades have shown that regular training is associated with the reduction of mortality among patients with breast cancer, and has an important role in inhibiting breast cancer progression as well as ...
Mahdiyeh Nasiri Ivanaki, Sirous Farsi, Hadi Ghaedi   +2 more
doaj  

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Serum IL-8 and VEGFA are Two Promising Diagnostic Biomarkers of Asthma-COPD Overlap Syndrome

International Journal of COPD, 2020
Qunli Ding,1 Shifang Sun,1 Yun Zhang,1 Pan Tang,1 Chengna Lv,1 Hongying Ma,1 Yiming Yu,1 Suling Xu,2 Zaichun Deng1 1Department of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Medical School of Ningbo University, Ningbo, People’s
Ding Q, Sun S, Zhang Y, Tang P, Lv C, Ma H, Yu Y, Xu S, Deng Z   +8 more
doaj  

Serum cytokine levels in breast cancer patients during neoadjuvant treatment with bevacizumab

OncoImmunology, 2018
A high concentration of circulating vascular endothelial growth factor (VEGF) in cancer patients is associated with an aggressive tumor phenotype. Here, serum levels of 27 cytokines and blood cell counts were assessed in breast cancer patients receiving ...
Shakila Jabeen, Manuela Zucknick, Marianne Nome, Ruth Dannenfelser, Thomas Fleischer, Surendra Kumar, Torben Lüders, Hedda von der Lippe Gythfeldt, Olga Troyanskaya, Jon Amund Kyte, Anne-Lise Børresen-Dale, Bjørn Naume, Xavier Tekpli, Olav Engebraaten, Vessela Kristensen   +14 more
doaj   +1 more source

INTERRELATIONSHIP OF THE MEDIATOR OF ANGIOGENESIS OF VEGF-A WITH GLUTATHIONE METABOLISM PARAMETERS AND THE CLINICAL CHARACTERISTICS OF SYSTEMIC AUTOIMMUNE DISEASES WITH JOINT DAMAGE

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2019
Introduction. In systemic autoimmune diseases with joint damage (SADJD), impaired angiogenesis occurs, which plays a key role in the progression of proliferative synovitis and in the development of lesions of the internal organs.
L. A. Alexandrova, N. A. Filippova, A. Iman, T. F. Subbotina, V. I. Trofimov   +4 more
doaj   +1 more source

Slow-Release Formulation of Cowpea Mosaic Virus for In Situ Vaccine Delivery to Treat Ovarian Cancer. [PDF]

, 2018
The plant viral nanoparticle cowpea mosaic virus (CPMV) is shown to be an effective immunotherapy for ovarian cancer when administered as in situ vaccine weekly, directly into the intraperitoneal (IP) space in mice with disseminated tumors.
Aguirre, Albertazzi, Bysell, Callahan, Cho, Cho, Conejo-Garcia, Corrales, Czapar, Dobrovolskaia, Emoto, Fransen, Hammerich, Jayson, Kostiainen, Kostiainen, LeBlond, Lin, Lizotte, Lomonossoff, Mikkilä, Mukherjee, Pandita, Pardoll, Pierce, Prokop, Singh, Smet, Stefano, Sun, Susman, Umeki, Veliz, Wallat, Wang, Wen, Wen, Wen, Winograd, Wright, Xu, Yoon   +41 more
core   +2 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

miR-124, miR-126-3p, and miR-200b: Potential therapeutic targets for VEGF-mediated complications in proliferative diabetic retinopathy

Indian Journal of Ophthalmology
Introduction: This study aimed to investigate alterations in intravitreal microRNA and vascular endothelial growth factor (VEGF) levels in patients with proliferative diabetic retinopathy (PDR) as these factors are implicated in PDR pathogenesis. Methods:
Irfan Akaray, Sadık Altan Ozal, Hilal Sancar, Ece Ozal, Lokman Ayaz   +4 more
doaj   +1 more source

Marked Long‐Term Improvement in Lung Function in Melanoma Differentiation–Associated Protein 5 Antibody–Positive Dermatomyositis Patients: Experience of a Single‐Center Longitudinal Cohort in North America

Arthritis Care &Research, EarlyView.
Objective The objective of this study was to describe the longitudinal disease course and pulmonary outcomes of North American patients with melanoma differentiation–associated protein 5 (MDA5) antibody–associated dermatomyositis (DM). Methods Thirty patients with MDA5 antibody–associated DM were identified in a single‐center longitudinal cohort of 352
Jenice X. Cheah, Sangmee S. Bae, Tiffany De Leon, Yuna Lee, Rong Guo, David Elashoff, Jennifer Wang, Ani Shahbazian, Christina Charles‐Schoeman   +8 more
wiley   +1 more source