Results 51 to 60 of about 285,367 (303)

Lymphatic vessel density and VEGF-C expression are significantly different among benign and malignant thyroid lesions [PDF]

, 2010
Thyroid cancer is the most frequent endocrine neoplasia worldwide. The route for metastasis and loco-regional invasion preferentially occurs by lymphatic vessels.
A Longatto-Filho, A Longatto-Filho, Adhemar Longatto-Filho, Alda Wakamatsu, AM Byrne, BHH Lang, Eduardo Anselmo Garcia, GNL Torre, H Kurahara, HJ Kahn, I Auwera Van der, J Afonso, JS Reis-Fillho, K Alitalo, Kleber Simões, L Jussila, M Fassnacht, MJ Karkkainen, MJ Schlumberger, N Weidner, NJ Beasley, P Bono, RJ Roskoski, Roberto Souza Camargo, Rodrigo Albergaria Ressio, RS Camargo, SA Stacker, SE Duff, T Kondo, TA Giorgadze, TP Padera, V Schacht, Venâncio Avancini Ferreira Alves, Y Yamazaki, Z Gombos   +34 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Serum VEGF, high-sensitivity CRP, and cystatin-C assist in the diagnosis of type 2 diabetic retinopathy complicated with hyperuricemia

Open Medicine, 2023
Elevated serum uric acid (UA) level is related to type 2 diabetic retinopathy (DR). Vascular endothelial growth factor (VEGF), high-sensitivity C-reactive protein (hs-CRP), and cystatin C (Cys-C) have involvement in type 2 DR complicated with ...
Wei Jing, Zhang Jincheng, Shi Yanan, Zhang Huiqin, Wu Yan   +4 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Long Noncoding RNA ASLNC07322 Functions in VEGF-C Expression Regulated by Smad4 during Colon Cancer Metastasis

Molecular Therapy: Nucleic Acids, 2019
Deletion and mutation of the Smad4 gene are favorable events for the progression of colon cancer, which is related to the negative regulation of vascular endothelial growth factor C (VEGF-C).
Xuemei Li, Xiaohong Lv, Zhuowei Li, Chao Li, Xinlei Li, Jianbing Xiao, Baoquan Liu, Huike Yang, Yafang Zhang   +8 more
doaj   +1 more source

Lymphangiogenesis and tumor metastasis [PDF]

, 2018
The lymphatic system transports interstitial fluid and macromolecules from tissues back to the blood circulation, and plays an important role in the immune response by directing the traffic of lymphocytes and antigen-presenting cells.
Nisato, Riccardo, Pepper, Michael, Skobe, Mihaela, Tille, Jean-Christophe   +3 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Proteolytic processing regulates receptor specificity and activity of VEGF-C [PDF]

The EMBO Journal, 1997
The recently identified vascular endothelial growth factor C (VEGF-C) belongs to the platelet-derived growth factor (PDGF)/VEGF family of growth factors and is a ligand for the endothelial-specific receptor tyrosine kinases VEGFR-3 and VEGFR-2. The VEGF homology domain spans only about one-third of the cysteine-rich VEGF-C precursor.
V, Joukov, T, Sorsa, V, Kumar, M, Jeltsch, L, Claesson-Welsh, Y, Cao, O, Saksela, N, Kalkkinen, K, Alitalo   +8 more
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Expression and Prognostic Value of VEGF-C and Lymphangeogenesis 
in Lung Adenocarcinoma and Squamous Cell Carcinoma

Chinese Journal of Lung Cancer, 2011
Background and objective Vascular endothelial growth factor-C (VEGF-C), a member of the VEGF family, has been proven to be a relatively special VEGF. When binding to its receptor VEGFR-3, it activates lymphangiogenesis, which likely induces lymph node ...
Xueli DAI, Wenli WANG, Yang SHEN-TU, Jie ZHANG   +3 more
doaj   +1 more source