Results 41 to 50 of about 285,367 (303)
KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D
eLife, 2019 Vascular endothelial growth factor-C (VEGF-C) acts primarily on endothelial cells, but also on non-vascular targets, for example in the CNS and immune system.
Sawan Kumar Jha +8 more
doaj +1 more source
VEGF-C and VEGF-D Blockade Inhibits Inflammatory Skin Carcinogenesis [PDF]
Cancer Research, 2013 Abstract VEGF-C and VEGF-D were identified as lymphangiogenic growth factors and later shown to promote tumor metastasis, but their effects on carcinogenesis are poorly understood. Here, we have studied the effects of VEGF-C and VEGF-D on tumor development in the murine multistep chemical carcinogenesis model of squamous cell ...
Alitalo, A. K. +8 more
openaire +2 more sources
Serum biomarkers VEGF-C and IL-6 are associated with severe human Peripheral Artery Stenosis [PDF]
, 2015 BACKGROUND: Emerging reports propose possible biomarkers that are related to inflammation, nutrition and lipid parameters for detection of the progression of atherosclerotic plaques, peripheral artery disease (PAD) and particularly peripheral artery ...
Bin Wei +5 more
core +1 more source
VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours [PDF]
Nature, 2020 Immune surveillance against pathogens and tumours in the central nervous system is thought to be limited owing to the lack of lymphatic drainage. However, the characterization of the meningeal lymphatic network has shed light on previously unappreciated ways that an immune response can be elicited to antigens that are expressed in the brain1-3. Despite
Song, Eric +8 more
openaire +2 more sources
Interleukin-6 Induces Vascular Endothelial Growth Factor-C Expression via Src-FAK-STAT3 Signaling in Lymphatic Endothelial Cells. [PDF]
PLoS ONE, 2016 Elevated serum interleukin-6 (IL-6) levels correlates with tumor grade and poor prognosis in cancer patients. IL-6 has been shown to promote tumor lymphangiogenesis through vascular endothelial growth factor-C (VEGF-C) induction in tumor cells.
Yu-Han Huang +5 more
doaj +1 more source
Brain homeostasis : VEGF receptor 1 and 2 ; two unequal brothers in mind [PDF]
, 2013 Vascular endothelial growth factors (VEGFs), initially thought to act specifically on the vascular system, exert trophic effects on neural cells during development and adulthood.
Plate, Karl H. +2 more
core +1 more source
Indian Journal of Pathology and MicrobiologyBackground: Vascular Endothelial Growth Factor-C (VEGF-C) plays a critical role in tumor growth and invasion through lymphangiogenesis and helps to identify the variability of lymphatic potential of oral squamous cell carcinoma (OSCC) cases with or ...
Ankita Tandon +3 more
doaj +1 more source
Analytical Cellular Pathology, 2015 In this study 80 malignant CMT were submitted to immunohistochemical detection of CD3, c-kit, VEGF, and CD31, together with clinicopathological parameters of tumor aggressiveness. CD3+ T-cells and c-kit overexpression revealed a positive correlation with
Maria Isabel Carvalho +6 more
doaj +1 more source
Digital Chinese Medicine, 2018 : Objective The effects of Shuang Dan Ming Mu capsule on expression of VEGF-a, VEGF-b, VEGF-c and the VEGF receptor, Flk-1, were examined in a diabetic retinopathy rats model.Methods Forty Sprague-Dawley (SD) rats were randomized into Groups A (blank), B
Jun PENG +4 more
doaj +1 more source
Correlation between Vegf-C Expression in Tissue and Serum Vegf-C in Patients with Bulky Cervical Cancer Receiving Paclitaxel – Carboplatin Neoadjuvan Chemotherapy [PDF]
, 2018 Background: The development of cervical cancer is highly dependent on the ability of cancer cells to form new capillaries and lymphatic vessels. Neo-adjuvant chemotherapy shrinks tumor size and reduces angiogenesis.
Andrijono, A. (Andrijono) +3 more
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