Results 31 to 40 of about 285,367 (303)

VEGF-C-mediated cardiac lymphangiogenesis in high salt intake accelerated progression of left ventricular remodeling in spontaneously hypertensive rats

Clinical and Experimental Hypertension, 2017
High salt (HS) diet can accelerate the progress of hypertensive left ventricular (LV) remodeling. But the detailed mechanism remains poorly understood. We hypothesized HS intake could impact cardiac lymphangiogenesis through tonicity-responsive enhancer ...
Guo-Hong Yang, Xin Zhou, Wen-Jie Ji, Jun-Xiang Liu, Jing Sun, Yan Dong, Tie-Min Jiang, Yu-Ming Li   +7 more
doaj   +1 more source

Gene Expression of VEGF-A and VEGF-C in Peripheral Blood Mononuclear Cells of Iranian Patients with Acute Myeloid Leukemia

Turkish Journal of Hematology, 2013
OBJECTIVE: The crucial role of angiogenesis in the pathophysiology of acute myeloid leukemia (AML) has been proposed. One of the key regulators of angiogenesis is the vascular endothelial growth factor (VEGF).
Mohammad Reza Aliparasti, Shohreh Almasi, Zohreh Sanaat, Aliakbar Movasaghpoor, Reza Khalili Dizaji, Homaun Sadeghi Bazargani   +5 more
doaj   +1 more source

Effect of vascular endothelial growth factors A, C, and D in HIV-associated pre-eclampsia

Hypertension in Pregnancy, 2017
Objective: To measure and correlate the level of vascular endothelial growth factors A, C, and D in HIV-associated pre-eclampsia. Methods: VEGF-A, VEGF-C, and VEGF-D were measured in serum of 76 normotensive and pre-eclamptic pregnant women stratified by
Gugulethu Promise Shange, Jagidesa Moodley, Thajasvarie Naicker   +2 more
doaj   +1 more source

VEGF-A, VEGF-C, and VEGF-D in Colorectal Cancer Progression

Neoplasia: An International Journal for Oncology Research, 2001
We aimed to assess the relationship of the angiogenic cytokines VEGF-A, VEGF-C, and VEGF-D and their receptors VEGFR-2 and VEGFR-3 in the adenomacarcinoma sequence and in metastatic spread of colorectal cancer (CRC).
Mark L. George, Matthew G. Tutton, Frank Janssen, Abed Arnaout, A. Muti Abulafi, Suzanne A. Eccles, R. Ian Swift   +6 more
doaj   +1 more source

Alginate hydrogels allow for bioactive and sustained release of VEGF-C and VEGF-D for lymphangiogenic therapeutic applications. [PDF]

PLoS ONE, 2017
Lymphatic dysfunction is associated with the progression of many cardiovascular disorders due to their role in maintaining tissue fluid homeostasis.
Kevin T Campbell, Dustin J Hadley, David L Kukis, Eduardo A Silva   +3 more
doaj   +1 more source

Biomarker analyses of clinical outcomes in patients with advanced hepatocellular carcinoma treated with Sorafenib with or without Erlotinib in the SEARCH Trial [PDF]

, 2016
Purpose: Sorafenib is the current standard therapy for advanced HCC, but validated biomarkers predicting clinical outcomes are lacking. This study aimed to identify biomarkers predicting prognosis and/or response to sorafenib, with or without erlotinib,
Evans, T.R. Jeffrey, Gane, Edward, Jeffers, Michael, Kang, Yoon-Koo, Meinhardt, Gerold, Peña, Carol E.A., Rosmorduc, Olivier, Ross, Paul, Santoro, Armando, Vogel, Arndt, Zhu, Andrew X.   +10 more
core   +1 more source

Complex formation of anti-VEGF-C with VEGF-C released during blood coagulation resulted in an artifact in its serum pharmacokinetics. [PDF]

Pharmacol Res Perspect, 2020
AbstractA phage‐derived human monoclonal antibody against VEGF‐C was developed as a potential anti‐tumor therapeutic and exhibited fast clearance in preclinical species, with notably faster clearance in serum than in plasma. The purpose of this work was to understand the factors contributing to its fast clearance.
Bumbaca Yadav D, Reyes AE, Gupta P, Vernes JM, Meng YG, Schweiger MG, Stainton SL, Fuh G, Fielder PJ, Kamath AV, Shen BQ.   +10 more
europepmc   +4 more sources

Distinct characteristics of circulating vascular endothelial growth factor-a and C levels in human subjects.

PLoS ONE, 2011
The mechanisms that lead from obesity to atherosclerotic disease are not fully understood. Obesity involves angiogenesis in which vascular endothelial growth factor-A (VEGF-A) plays a key role.
Hiromichi Wada, Shuichi Ura, Shuji Kitaoka, Noriko Satoh-Asahara, Takahiro Horie, Koh Ono, Tomohide Takaya, Rieko Takanabe-Mori, Masaharu Akao, Mitsuru Abe, Tatsuya Morimoto, Toshinori Murayama, Masayuki Yokode, Masatoshi Fujita, Akira Shimatsu, Koji Hasegawa   +15 more
doaj   +1 more source

Synaptonemal complex protein 3 is associated with lymphangiogenesis in non-small cell lung cancer patients with lymph node metastasis

Journal of Translational Medicine, 2017
Background The interaction of vascular endothelial growth factor-C (VEGF-C)/VEGF-D/VEGF receptor-3 is considered to be a major driver of lymphangiogenesis, however the mechanism of this process remains unclear.
Haruhisa Kitano, Joon-Yong Chung, Kyung Hee Noh, Young-Ho Lee, Tae Woo Kim, Seok Hyung Lee, Soo-Heang Eo, Hyung Jun Cho, Chel Hun Choi, Shuhei Inoue, Jun Hanaoka, Junya Fukuoka, Stephen M. Hewitt   +12 more
doaj   +1 more source

VEGF-C Gene Polymorphisms Increase Susceptibility to Rheumatoid Arthritis [PDF]

International Journal of Medical Sciences, 2019
Vascular endothelial growth factor C (VEGF-C) promotes angiogenesis, a prominent feature in rheumatoid synovitis, contributing to the perpetuation of the global burden of rheumatoid arthritis (RA). VEGF-C gene polymorphisms predict the risk of developing various human diseases, such as urothelial cell carcinoma, oral cancer and coronary artery disease.
Dai, Chengqian, Kuo, Shu-Jui, Hu, Sung-Lin, Tsai, Chun-Hao, Huang, Yuan-Li, Huang, Chien-Chung, Wang, Lihong, Xu, Guohong, Su, Chen-Ming, Tang, Chih-Hsin   +9 more
openaire   +2 more sources