Results 21 to 30 of about 285,367 (303)

VEGF-C — a biomarker of renal injury in the experimental model of intra-abdominal hypertension

Сеченовский вестник, 2020
Lymphangiogenesis plays an important role in development of renal parenchyma inflammation during kidney injury. Vascular endothelial growth factor type C (VEGF-C), cytokine that regulates lymphangiogenesis, is a potential early biomarker for acute kidney
V. V. Iakovlev, A. V. Badaeva, E. I. Ivanova, L. O. Severgina, L. D. Maltseva, O. L. Morozova   +5 more
doaj   +1 more source

Phage-derived fully human monoclonal antibody fragments to human vascular endothelial growth factor-C block its interaction with VEGF receptor-2 and 3. [PDF]

PLoS ONE, 2010
Vascular endothelial growth factor C (VEGF-C) is a key mediator of lymphangiogenesis, acting via its receptors VEGF-R2 and VEGF-R3. High expression of VEGF-C in tumors correlates with increased lymphatic vessel density, lymphatic vessel invasion ...
Matthias Rinderknecht, Alessandra Villa, Kurt Ballmer-Hofer, Dario Neri, Michael Detmar   +4 more
doaj   +1 more source

DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination

Journal of Extracellular Vesicles, 2020
Early dissemination is a unique characteristic and a detrimental process of pancreatic ductal adenocarcinoma (PDAC); however, the underlying mechanism remains largely unknown.
Chu-An Wang, I-Heng Chang, Pei-Chi Hou, Yu-Jing Tai, Wan-Ning Li, Pei-Ling Hsu, Shang-Rung Wu, Wen-Tai Chiu, Chien-Feng Li, Yan-Shen Shan, Shaw-Jenq Tsai   +10 more
doaj   +1 more source

AXL promotes lymphangiogenesis by amplifying VEGF-C-mediated AKT pathway. [PDF]

Cell Mol Life Sci
Lymphangiogenesis has gained considerable interest due to its established role in cancer progression and dissemination of metastatic cells through lymph nodes. Deciphering the molecular mechanisms that govern lymphangiogenesis within lymph nodes holds promise for revealing novel targetable molecules and pathways to inhibit metastasis. In this study, we
Pirson S, Gautier-Isola M, Baudin L, Rouaud L, Vanwynsberghe A, Deroye J, Bekisz S, Gucciardo F, Lebeau A, Buntinx F, Ivanova E, Staumont B, Blacher S, Gilles C, Noël A.   +14 more
europepmc   +4 more sources

Proteolytic Cleavages in the VEGF Family: Generating Diversity among Angiogenic VEGFs, Essential for the Activation of Lymphangiogenic VEGFs

Biology, 2021
Specific proteolytic cleavages turn on, modify, or turn off the activity of vascular endothelial growth factors (VEGFs). Proteolysis is most prominent among the lymph­angiogenic VEGF-C and VEGF-D, which are synthesized as precursors that need to undergo ...
Jaana Künnapuu, Honey Bokharaie, Michael Jeltsch   +2 more
doaj   +1 more source

Expressions of COX-2 and VEGF-C in gastric cancer: correlations with lymphangiogenesis and prognostic implications [PDF]

, 2011
Background Cyclooxygenase-2 (COX-2) has recently been considered to promote lymphangiogenesis by up-regulating vascular endothelial growth factor-C (VEGF-C) in breast and lung cancer.
Hong-Feng Gou, Xin-Chuan Chen, Jiang Zhu, Ming Jiang, Yu Yang, Dan Cao, Mei Hou   +6 more
core   +1 more source

Heparanase induces VEGF C and facilitates tumor lymphangiogenesis [PDF]

International Journal of Cancer, 2008
AbstractHeparanase is an endoglycosidase that specifically cleaves heparan sulfate side chains, a class of glycosaminoglycans abundantly present in the extracellular matrix and on the cell surface. Heparanase activity is strongly implicated in tumor angiogenesis and metastasis attributed to remodeling of the subepithelial and subendothelial basement ...
Victoria, Cohen-Kaplan, Inna, Naroditsky, Anna, Zetser, Neta, Ilan, Israel, Vlodavsky, Ilana, Doweck   +5 more
openaire   +2 more sources

VEGF Expression in Colorectal Cancer Metastatic Lymph Nodes: Clinicopathological Correlation and Prognostic Significance

Gastrointestinal Disorders, 2020
Background: Angiogenesis plays an important role in colorectal cancer (CRC) tumorigenesis and metastatic progression. Methods: The present series consisted of CRC lymph node metastasis (LNM) tissue samples from 210 patients.
Inês Mazeda, Sandra F. Martins, Eduardo A. Garcia, Mesquita Rodrigues, Adhemar Longatto   +4 more
doaj   +1 more source

Local induction of lymphangiogenesis with engineered fibrin-binding VEGF-C promotes wound healing by increasing immune cell trafficking and matrix remodeling [PDF]

, 2017
Lymphangiogenesis occurs in inflammation and wound healing, yet its functional roles in these processes are not fully understood. Consequently, clinically relevant strategies for therapeutic lymphangiogenesis remain underdeveloped, particularly using ...
Achen, Baluk, Baluk, Baluk, Baluk, Beauvillain, Boardman, Briquez, Broggi, Card, Didier Foretay, Djonov, Ehrbar, Epstein, Esra Güç, Fonseca, Forster, Goldman, Goldman, Guc, Helm, Hoshida, Isaka, Issa, Janmey, Jeffrey A. Hubbell, Jeltsch, Johnson, Johnson, Joukov, Kilarski, Kilarski, Kilarski, Kilarski, Kilarski, Kim, Kukk, Lammermann, Lawrance, Lee, Lorentz, Lorentz, Lutolf, Manuel A. Fankhauser, Martino, Martino, Martino, Maruyama, Melody A. Swartz, Mitchell, Ng, Ng, Ng, Norrmen, Olszewski, Paavonen, Pepper, Petrova, Podgrabinska, Priscilla S. Briquez, Rigby, Roth, Rutkowski, Saaristo, Saaristo, Saaristo, Saeki, Schense, Seliktar, Shepro, Swartz, Swartz, Szuba, Tammela, Tomasek, Venugopal, Wetzler, Witold W. Kilarski, Yao   +78 more
core   +1 more source

Slit2N and Robo4 regulate lymphangiogenesis through the VEGF-C/VEGFR-3 pathway [PDF]

, 2014
Background: Signaling through vascular endothelial growth factor C (VEGF–C) and VEGF receptor 3 (VEGFR-3) plays a central role in lymphangiogenesis and the metastasis of several cancers via the lymphatics.
Groopman, Jerome E, Jiang, Shuxian, Kuzontkoski, Paula M, Li, Dean Y, Yu, Jinlong, Zhang, Xuefeng, Zhu, Weiquan   +6 more
core   +2 more sources