Bioactive VEGF-C from E. coli [PDF]
Scientific Reports, 2022 Vascular endothelial growth factor-C (VEGF-C) stimulates lymphatic vessel growth in transgenic models, via viral gene delivery, and as a recombinant protein.
Khushbu Rauniyar +4 more
doaj +6 more sources
Recombinant VEGF-C (Cys156Ser) improves mesenteric lymphatic drainage and gut immune surveillance in experimental cirrhosis [PDF]
JHEP Reports, 2023 Background & Aims: Lymphatic vessels (LVs) are crucial for maintaining abdominal fluid homoeostasis and immunity. In cirrhosis, mesenteric LVs (mLVs) are dilated and dysfunctional.
Pinky Juneja +15 more
doaj +2 more sources
ADSCs stimulated by VEGF-C alleviate intestinal inflammation via dual mechanisms of enhancing lymphatic drainage by a VEGF-C/VEGFR-3-dependent mechanism and inhibiting the NF-κB pathway by the secretome [PDF]
Stem Cell Research & Therapy, 2022 Background Adipose-derived stem cells (ADSCs) have provided promising applications for Crohn’s disease (CD). However, the practical efficacy of ADSCs remains controversial, and their mechanism is still unclear.
Lei Zhang +6 more
doaj +2 more sources
DNA methylation regulates expression of VEGF-C, and S-adenosylmethionine is effective for VEGF-C methylation and for inhibiting cancer growth [PDF]
Brazilian Journal of Medical and Biological Research, 2014 DNA hypomethylation may activate oncogene transcription, thus promoting carcinogenesis and tumor development. S-adenosylmethionine (SAM) is a methyl donor in numerous methylation reactions and acts as an inhibitor of intracellular demethylase activity ...
M.X. Da, Y.B. Zhang, J.B. Yao, Y.X. Duan
doaj +4 more sources
MMP13 Regulates Aggressiveness of Pediatric Multiple Myeloma Through VEGF-C
Cellular Physiology and Biochemistry, 2015 Background/Aims: Even though the blood and lymphatic vascular systems are both involved in the occurrence of cancer metastases, it is believed that lymphatic system is primarily responsible for the initial metastasis.
Lingyun Xu +4 more
doaj +3 more sources
VEGF-C and p53 Gene Expression in the Normal and Neoplastic Mammary Gland of Canines: A Pilot Study [PDF]
Journal of Cell and Molecular Research, 2021 p53 is a tumor suppressor protein that plays an essential role in controlling the cell and vascular endothelial growth factor (VEGF) is one of the most strong and specific angiogenic factors. The main objective of this study was to evaluate the impact of
Mohammadreza Nassiri +6 more
doaj +1 more source
VEGF-C promotes survival in podocytes [PDF]
American Journal of Physiology-Renal Physiology, 2006 Vascular endothelial growth factor (VEGF)-A is an autocrine survival factor for podocytes, which express two VEGF receptors, VEGF-R1 and VEGF-R3. As VEGF-A is not a known ligand for VEGF-R3, the aim of this investigation was to examine whether VEGF-C, a known ligand for VEGF-R3, served a function in podocyte biology and whether this was VEGF-R3 ...
Harper, SJ +9 more
openaire +4 more sources
VEGF-C et vaisseaux lymphatiques [PDF]
médecine/sciences, 2019 Le système lymphatique est formé de vaisseaux qui drainent les liquides interstitiels dans tout l’organisme. La circulation de la lymphe dans les vaisseaux lymphatiques est unidirectionnelle : des tissus vers les ganglions lymphatiques puis les veines.
Papa Diogop Ndiaye, Gilles Pagès
openaire +1 more source
Characterization of murine Flt4 ligand/VEGF-C [PDF]
Oncogene, 1997 Flt4 is a receptor protein tyrosine kinase that is expressed in the adult lymphatic endothelium and high endothelial venules. We have used a BIAcore assay to identify rodent and human cell conditioned media containing the ligand of Flt4 (Flt4-L). Receptor-based affinity chromatography was used to purify this growth factor, followed by amino acid ...
L J, Fitz +17 more
openaire +2 more sources
Migration-promoting role of VEGF-C and VEGF-C binding receptors in human breast cancer cells [PDF]
British Journal of Cancer, 2007 Vascular endothelial growth factor C (VEGF-C) is a lymphangiogenic factor over-expressed in highly metastatic, cyclooxygenase (COX)-2 expressing breast cancer cells. We tested the hypothesis that tumour-derived VEGF-C may play an autocrine role in metastasis by promoting cellular motility through one or more VEGF-C-binding receptors VEGFR-2, VEGFR-3 ...
Timoshenko, A V, Rastogi, S, Lala, P K
openaire +2 more sources