Results 11 to 20 of about 20,098,805 (300)

VEGF-C promotes survival in podocytes [PDF]

American Journal of Physiology-Renal Physiology, 2006
Vascular endothelial growth factor (VEGF)-A is an autocrine survival factor for podocytes, which express two VEGF receptors, VEGF-R1 and VEGF-R3. As VEGF-A is not a known ligand for VEGF-R3, the aim of this investigation was to examine whether VEGF-C, a known ligand for VEGF-R3, served a function in podocyte biology and whether this was VEGF-R3 ...
Harper, SJ, Foster, RR, Satchell, SC, Seckley, J, Emmett, MS, Joory, K, Xing, CY, Saleem, MA, Mathieson, PW, Bates, DO   +9 more
openaire   +5 more sources

DNA methylation regulates expression of VEGF-C, and S-adenosylmethionine is effective for VEGF-C methylation and for inhibiting cancer growth [PDF]

Brazilian Journal of Medical and Biological Research, 2014
DNA hypomethylation may activate oncogene transcription, thus promoting carcinogenesis and tumor development. S-adenosylmethionine (SAM) is a methyl donor in numerous methylation reactions and acts as an inhibitor of intracellular demethylase activity ...
M.X. Da, Y.B. Zhang, J.B. Yao, Y.X. Duan
doaj   +4 more sources

An Important Role of VEGF-C in Promoting Lymphedema Development [PDF]

Journal of Investigative Dermatology, 2017
Secondary lymphedema is a common complication after cancer treatment, but the pathomechanisms underlying the disease remain unclear. Using a mouse tail lymphedema model, we found an increase in local and systemic levels of the lymphangiogenic factor vascular endothelial growth factor (VEGF)-C and identified CD68+ macrophages as a cellular source ...
Gousopoulos, Epameinondas, Proulx, Steven T, Bachmann, Samia B, Dieterich, Lothar C, Scholl, Jeannette, Karaman, Sinem, Bianchi, Roberta, Detmar, Michael   +7 more
openaire   +8 more sources

KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D [PDF]

eLife, 2019
Vascular endothelial growth factor-C (VEGF-C) acts primarily on endothelial cells, but also on non-vascular targets, for example in the CNS and immune system.
Sawan Kumar Jha, Khushbu Rauniyar, Ewa Chronowska, Kenny Mattonet, Eunice Wairimu Maina, Hannu Koistinen, Ulf-Håkan Stenman, Kari Alitalo, Michael Jeltsch   +8 more
doaj   +2 more sources

VEGF-A, VEGF-C, and VEGF-D in Colorectal Cancer Progression

Neoplasia: An International Journal for Oncology Research, 2001
We aimed to assess the relationship of the angiogenic cytokines VEGF-A, VEGF-C, and VEGF-D and their receptors VEGFR-2 and VEGFR-3 in the adenomacarcinoma sequence and in metastatic spread of colorectal cancer (CRC).
Mark L. George, Matthew G. Tutton, Frank Janssen, Abed Arnaout, A. Muti Abulafi, Suzanne A. Eccles, R. Ian Swift   +6 more
doaj   +2 more sources

Current biology of VEGF-B and VEGF-C

Current Opinion in Biotechnology, 1999
Endothelial growth factors and their receptors may provide important therapeutic tools for the treatment of pathological conditions characterised by defective or aberrant angiogenesis. Vascular endothelial growth factor (VEGF) is pivotal for vasculogenesis and for angiogenesis in normal and pathological conditions.
B, Olofsson, M, Jeltsch, U, Eriksson, K, Alitalo   +3 more
openaire   +3 more sources

VEGF-A/VEGF-B/VEGF-C expressions in non-hereditary, non-metastatic phaeochromocytoma. [PDF]

, 2021
Vascular endothelial growth factor (VEGF) is important in pathogenesis of different cancers. The aim of this study is to investigate the relationships between different VEGFs and clinicopathological factors in patients with phaeochromocytomas.
Pillai, Suja, Islam, Farhadul, Lo, Chung Yau, Lam, Alfred K, Abe, Ichiro, Liew, Victor   +5 more
core   +3 more sources

Use of VEGF-C to prevent restenosis [PDF]

, 2005
The present invention provides materials and methods for preventing stenosis or restenosis of a blood vessel using Vascular Endothelial Growth Factor C (VEGF-C) and/or Vascular Endothelial Growth Factor D (VEGF-D) genes or ...
ALITALO KARI, YLA-HERTTUALA SEPPO, HILTUNEN MIKKO O, JELTSCH MARKKU M   +3 more
openaire   +2 more sources

Migration-promoting role of VEGF-C and VEGF-C binding receptors in human breast cancer cells [PDF]

British Journal of Cancer, 2007
Vascular endothelial growth factor C (VEGF-C) is a lymphangiogenic factor over-expressed in highly metastatic, cyclooxygenase (COX)-2 expressing breast cancer cells. We tested the hypothesis that tumour-derived VEGF-C may play an autocrine role in metastasis by promoting cellular motility through one or more VEGF-C-binding receptors VEGFR-2, VEGFR-3 ...
Timoshenko, A V, Rastogi, S, Lala, P K
openaire   +2 more sources

Characterization of murine Flt4 ligand/VEGF-C [PDF]

Oncogene, 1997
Flt4 is a receptor protein tyrosine kinase that is expressed in the adult lymphatic endothelium and high endothelial venules. We have used a BIAcore assay to identify rodent and human cell conditioned media containing the ligand of Flt4 (Flt4-L). Receptor-based affinity chromatography was used to purify this growth factor, followed by amino acid ...
L J, Fitz, J C, Morris, P, Towler, A, Long, P, Burgess, R, Greco, J, Wang, R, Gassaway, E, Nickbarg, S, Kovacic, A, Ciarletta, J, Giannotti, H, Finnerty, R, Zollner, D R, Beier, L V, Leak, K J, Turner, C R, Wood   +17 more
openaire   +2 more sources