Bottom‐Up Programming of Cell States in Cancer Organoids with Defined Synthetic Adhesion Cues
Advanced Materials, EarlyView.A bottom‐up biomaterial platform is developed to program transcriptomic states in pancreatic cancer organoids by tuning adhesion cues within synthetic matrices. By combining a Design of Experiments framework with multiobjective optimization, matrix compositions are identified that enrich specific cellular programs like EMT.
Ali Nadernezhad +6 more
wiley +1 more source
Vasohibin 2 promotes lymphangiogenesis of lung squamous cell carcinoma through snail-dependent vascular endothelial growth factor-D (VEGF-D) signaling pathway. [PDF]
Ann Transl Med, 2022 Liu P +8 more
europepmc +1 more source
Chicken Embryo as Model for Effects of Nnitrosodimethylamine Using Morphology, Haematology and Proteomic Analyses During Embryogenesis [PDF]
, 2009 This study was carried out to investigate the developmental toxicity effects of an established carcinogen namely N-Nitrosodimethylamine (NDMA) and its administration method on the early and mid embryogenesis of chicken. The study was also conducted to
Sulaiman, Mohd Rosni
core
Hydrogel‐Based Airway‐on‐Tube With Perfusable Endothelial Lumen and Outward Epithelialization
Advanced Materials, EarlyView.A hydrogel‐based airway‐on‐tube platform featuring a perfusable endothelial lumen and outward epithelialization is presented. The system supports primary human bronchial epithelial and lung microvascular endothelial coculture under air‐liquid interface conditions.
Ali Doryab +8 more
wiley +1 more source
淋巴生成因子VEGF-C、VEGF-D在家兔颅底组织中的表达
Zhongguo shiyan zhenduanxue, 2008 目的观察家兔颅底组织:颈内动脉、硬膜和视神经中淋巴生成因子VEGF-C、VEGF-D蛋白表达,探讨家兔颅底淋巴转移途径。方法应用免疫组化染色、图像分析方法检测淋巴生成因子VEGF-C、VEGF-D在家兔颅底组织（颈内动脉、硬膜和视神经）中的蛋白表达,与脑组织中VEGF-C、VEGF-D蛋白表达比较,分析其差异。结果VEGF-C、VEGF-D在颈内动脉和硬膜中高表达,在视神经和脑组织中低表达。其中VEGF-C、VEGF-D在颈内动脉中的表达高于硬膜,二者比较,差异显著 ...
高宇飞 +4 more
doaj
circEHBP1 promotes lymphangiogenesis and lymphatic metastasis of bladder cancer via miR-130a-3p/TGFβR1/VEGF-D signaling. [PDF]
Mol Ther, 2021 Zhu J +11 more
europepmc +1 more source
AI–Guided 4D Printing of Carnivorous Plants–Inspired Microneedles for Accelerated Wound Healing
Advanced Materials, EarlyView.This work presents an artificial intelligence (AI)‐guided 4D‐printed microneedle platform inspired by carnivorous plants for wound healing. A thermo‐responsive shape memory polymer enables body temperature–triggered self‐coiling for autonomous wound closure.
Hyun Lee +21 more
wiley +1 more source
Conductive Hydrogels for Exogenous Sensing and Cell Fate Control
Advanced Materials, EarlyView.We engineer electrically conductive hydrogels by combining sulfated glycosaminoglycans with semiconducting polymers. These hydrogels bind bioactive proteins, including growth factors, whose release or retention can be modulated by low‐voltage stimulation. The hydrogels are also integrated as 3D channels in organic electrochemical transistors as part of
Teuku Fawzul Akbar +15 more
wiley +1 more source
Fabrication, Properties, and Applications of Scaffolds for Bone Tissue Regeneration
Advanced Materials Technologies, EarlyView.This review explores cutting‐edge biomaterials and fabrication techniques for scaffolds in bone tissue regeneration. It conducts a critical comparison of various strategies, meticulously analyzes the key contradictions in the field, and outlines an integrated development path spanning from biomaterial selection to clinical application, while ...
Shangsi Chen, Min Wang
wiley +1 more source
VEGF-C、COX-2、Cath-D在MDS患者血清中的表达及意义
Zhongguo shiyan zhenduanxue, 2015 目的探讨血管内皮生长因子-C（vascular endothelial growth factor-C,VEGF-C）、环氧化酶-2（cyclooxygenase 2,COX-2）、组织蛋白酶-D（cathepsin-D,Cath-D）在骨髓增生异常综合症（myelodysplastic syndromes,MDS）患者血清中的表达水平及意义。方法采用酶联免疫吸附法（ELISA）定量检测44例MDS患者、50例正常健康人血清中的VEGF-C、COX-2、Cath-D含量并进行比较。结果 ...
卢志贤, 王亚萍, 谢敏瑚
doaj