Oftalʹmologiâ, 2014 Development of late microvascular complications — diabetic retinopathy, nephropathy and neuropathy — in type 2 diabetic pa- tients is associated with higher invalidization risk and lethality.
I. V. Vorobieva, D. A. Merkushenkova
doaj +1 more source
miR-15a-5p suppresses peritoneal fibrosis induced by peritoneal dialysis via targeting VEGF in rats
Renal Failure, 2020 Aim When peritoneal fibrosis (PF) causes ultrafiltration failure in peritoneal dialysis (PD) patients, PD has to be discontinued. Currently, there is no effective way to relieve PF.
Qianxin He +9 more
doaj +1 more source
Control of VEGF-A transcriptional programs by pausing and genomic compartmentalization. [PDF]
, 2014 Vascular endothelial growth factor A (VEGF-A) is a master regulator of angiogenesis, vascular development and function. In this study we investigated the transcriptional regulation of VEGF-A-responsive genes in primary human aortic endothelial cells ...
Benner, Christopher +9 more
core +1 more source
RUDN Journal of Medicine, 2022 In the modern paradigm of public health protection, much attention is paid to the health of women in peri- and postmenopause, and a personalized approach prevails.
Irina S. Zhuravleva +4 more
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VEGF₁₂₁b and VEGF₁₆₅b are weakly angiogenic isoforms of VEGF-A.
Molecular cancer, 2010 Different isoforms of VEGF-A (mainly VEGF₁₂₁, VEGF₁₆₅ and VEGF189) have been shown to display particular angiogenic properties in the generation of a functional tumor vasculature. Recently, a novel class of VEGF-A isoforms, designated as VEGF(xxx)b, generated through alternative splicing, have been described.
Pio, R. (Rubén) +9 more
openaire +3 more sources
Clinical significance of VEGF-A, -C and -D expression in esophageal malignancies [PDF]
, 2005 Vascular endothelial growth factors ( VEGF)- A, - C and - D are members of the proangiogenic VEGF family of glycoproteins. VEGF-A is known to be the most important angiogenic factor under physiological and pathological conditions, while VEGF-C and VEGF-D
Ahn MJ +48 more
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Umbelliprenin Inhibited Angiogenesis and Metastasis of MDA-MB-231 Cell Line through Downregulation of CoCl2 / EGFMediated PI3K / AKT / ERK Signaling [PDF]
Middle East Journal of Cancer, 2022 Background: Breast cancer is known to be one of the most prevalent malignancies in women worldwide. Umbelliprenin (UMB) is a naturally-occurring component derived from plant species, which has shown anticancer properties.
Somayeh Mahmoodi Khatonabadi +7 more
doaj +1 more source
VEGF-Independent Angiogenic Factors: Beyond VEGF/VEGFR2 Signaling [PDF]
Journal of Vascular Research, 2022 Tumors induce angiogenesis to acquire oxygen and nutrition from their adjacent microenvironment. Tumor angiogenesis has been believed to be induced primarily by the secretion of vascular endothelial growth factor-A (VEGF-A) from various tumors.
Ryoji Eguchi +2 more
openaire +2 more sources
Biomarker analyses of clinical outcomes in patients with advanced hepatocellular carcinoma treated with Sorafenib with or without Erlotinib in the SEARCH Trial [PDF]
, 2016 Purpose: Sorafenib is the current standard therapy for advanced HCC, but validated biomarkers predicting clinical outcomes are lacking. This study aimed to identify biomarkers predicting prognosis and/or response to sorafenib, with or without erlotinib,
Evans, T.R. Jeffrey +10 more
core +1 more source
NF-κB signaling and crosstalk during carcinogenesis
4 open, 2019 Transcription factors (TFs) are proteins that control the transcription of genetic information from DNA to mRNA by binding to specific DNA sequences either on their own or with other proteins as a complex.
Brücher Björn L.D.M. +2 more
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