Results 11 to 20 of about 29,745,998 (266)

Heterodimerisation between VEGFR-1 and VEGFR-2 and not the homodimers of VEGFR-1 inhibit VEGFR-2 activity [PDF]

Vascular Pharmacology, 2017
Vascular endothelial growth factor (VEGF) signaling is tightly regulated by specific VEGF receptors (VEGF-R). Recently, we identified heterodimerisation between VEGFR-1 and VEGFR-2 (VEGFR1-2) to regulate VEGFR-2 function. However, both the mechanism of action and the relationship with VEGFR-1 homodimers remain unknown.
Meng Cai, Keqing Wang, Colin E. Murdoch, Yuchun Gu, Asif Ahmed   +4 more
openaire   +6 more sources

Attenuation of VEGFR-2 expression by sFlt-1 and low oxygen in human placenta. [PDF]

PLoS ONE, 2013
Vascular endothelial growth factor receptor 2 (VEGFR-2), the primary receptor for VEGF, is crucial for normal endothelial function. sFlt-1, a truncated and soluble form of VEGFR-1 which binds and inhibits VEGF, is increased in preeclampsia and is ...
Ori Nevo, Dennis K Lee, Isabella Caniggia   +2 more
doaj   +2 more sources

Placental Pathology and Placental Growth Factor (PlGF)/Vascular Endothelial Growth Factor Receptor-1 (VEGFR-1) Pathway Expression Evaluation in Fetal Congenital Heart Defects [PDF]

Life
The heart and placenta have simultaneous embryologic development, the interactions between the two organs representing the heart–placental axis. They both share key developmental pathways, one of which involves the placental growth factor (PlGF) and its ...
Alexandru Cristian Bolunduț, Ximena Maria Mureșan, Rada Teodora Suflețel, Lavinia Patricia Mocan, Simina Pîrv, Sergiu Șușman, Carmen Mihaela Mihu   +6 more
doaj   +2 more sources

Notch regulates the angiogenic response via induction of VEGFR-1 [PDF]

Journal of Angiogenesis Research, 2010
Notch is a critical regulator of angiogenesis and arterial specification. We show that ectopic expression of activated Notch1 induces endothelial morphogenesis in human umbilical vein endothelial cells (HUVEC) in a VEGFR-1-dependent manner. Notch1-mediated upregulation of VEGFR-1 in HUVEC increased their responsiveness to the VEGFR-1 specific ligand ...
Funahashi, Yasuhiro, Shawber, Carrie, Vorontchikhina, Marina, Sharma, Anshula, Outtz, Hasina, Kitajewski, Jan K.   +5 more
openaire   +7 more sources

VEGF, VEGFR-1 and VEGFR-2 immunoreactivity in the porcine arteries of vascular subovarian plexus (VSP) during the estrous cycle. [PDF]

Folia Histochemica et Cytobiologica, 2006
: Vascular endothelial growth factor (VEGF) is an important angiogenic factor in the female reproductive tract. It binds to cell surface through ligand-stimulatable tyrosine kinase receptors, the most important being VEGFR-1 (flt-1) and VEGFR-2 (flk-1 ...
A Andronowska, A Postek, T Doboszyńska, H Niewegłowski, K Jankowska   +4 more
doaj   +3 more sources

VEGFR-1 Regulates EGF-R to Promote Proliferation in Colon Cancer Cells. [PDF]

Int J Mol Sci, 2019
The relationship between epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) pathways in tumor growth is well established. EGF induces VEGF production in cancer cells, and the paracrine VEGF activates vascular endothelial cells to promote tumor angiogenesis and thus supports tumor cell growth in an angiogenesis-dependent manner.
Nagano H, Tomida C, Yamagishi N, Teshima-Kondo S.   +3 more
europepmc   +3 more sources

The Anti-Vascular Endothelial Growth Factor Receptor 1 (VEGFR-1) D16F7 Monoclonal Antibody Inhibits Melanoma Adhesion to Soluble VEGFR-1 and Tissue Invasion in Response to Placenta Growth Factor. [PDF]

Cancers (Basel), 2022
Melanoma is an aggressive cancer type with a high tendency to spread to distant body sites, including bones. Despite the availability of effective therapies, many patients still do not fully benefit from treatment.
Atzori MG, Ceci C, Ruffini F, Scimeca M, Cicconi R, Mattei M, Lacal PM, Graziani G.   +7 more
europepmc   +2 more sources

Correction: VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody. [PDF]

J Exp Clin Cancer Res
Micheli L, Parisio C, Lucarini E, Vona A, Toti A, Pacini A, Mello T, Boccella S, Ricciardi F, Maione S, Graziani G, Lacal PM, Failli P, Ghelardini C, Di Cesare Mannelli L.   +14 more
europepmc   +3 more sources

Pigment Epithelium-Derived Factor Binding to VEGFR-1 (Flt-1) Increases the Survival of Retinal Neurons. [PDF]

Invest Ophthalmol Vis Sci
PURPOSE The purpose of this study was to examine possible involvement of vascular endothelial growth factor (VEGF) receptor (VEGFR)-1/Flt-1 in pigment epithelium-derived factor (PEDF)-promoted survival of retinal neurons.
Meng J, Yang XM, Scheer O, Lange J, Müller H, Bürger S, Rothemund S, Younis R, Unterlauft JD, Eichler W.   +9 more
europepmc   +4 more sources

VEGF-A/VEGFR-1: a painful astrocyte-mediated signaling blocked by the anti-VEGFR-1 mAb D16F7 [PDF]

, 2021
Abstract Chemotherapy-induced neuropathic pain is a clinically relevant adverse effect of several anticancer drugs leading to dose reduction or therapy discontinuation. The lack of knowledge about the mechanisms of neuropathy development and pain chronicization makes chemotherapy-induced neuropathic pain treatment an unmet medical need.
Laura Micheli, Carmen Parisio, Elena Lucarini, Alessia Vona, Alessandra Toti, Alessandra Pacini, Tommaso Mello, Serena Boccella, Flavia Ricciardi, Sabatino Maione, Grazia Graziani, Pedro Miguel Lacal, Paola Failli, Carla Ghelardini, Lorenzo Di Cesare Mannelli   +14 more
openaire   +1 more source