Results 31 to 40 of about 29,745,998 (266)

Vascular Endothelial Growth Factor Receptor-1 Modulates Hypoxia-Mediated Endothelial Senescence and Cellular Membrane Stiffness via YAP-1 Pathways

Frontiers in Cell and Developmental Biology, 2022
Hypoxia-induced endothelial cell (EC) dysfunction has been implicated as potential initiators of different pathogenesis, including Alzheimer’s disease and vascular dementia. However, in-depth structural, mechanical, and molecular mechanisms leading to EC
Ramcharan Singh Angom, Tanmay Kulkarni, Enfeng Wang, Shamit Kumar Dutta, Santanu Bhattacharya, Santanu Bhattacharya, Pritam Das, Debabrata Mukhopadhyay, Debabrata Mukhopadhyay   +8 more
doaj   +1 more source

Structural and functional characterization of the intracellular kinase domain of vascular endothelial growth factor receptor-2 [PDF]

, 2013
Vascular Endothelial Growth Factors (VEGFs) are key players in blood and lymphatic vessel development and homeostasis. The family consists of five members, VEGF-A, -B, -C, -D and placenta growth factor (PLGF).
Manni, Sandro
core   +1 more source

Brain homeostasis : VEGF receptor 1 and 2 ; two unequal brothers in mind [PDF]

, 2013
Vascular endothelial growth factors (VEGFs), initially thought to act specifically on the vascular system, exert trophic effects on neural cells during development and adulthood.
Karl H. Plate, Plate, Karl, Wittko-Schneider, Ina M., Schneider, Fabian T., Fabian T. Schneider, Ina M. Wittko-Schneider   +5 more
core   +1 more source

Additional file 7 of VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody

, 2021
Additional file 7: Figure S6. VEGFR-2 is increased in the spinal cord of mice with oxaliplatin-induced neuropathy. Representative western blot images and densitometric analysis of VEGF-R1 and VEGFR-2 expression in the lumbar section of the spinal cord of
Lorenzo Di Cesare Mannelli (600627), Sabatino Maione (140730), Pedro Miguel Lacal (11567064), Carla Ghelardini (600626), Paola Failli (443253), Alessia Vona (11567061), Flavia Ricciardi (6590378), Alessandra Pacini (748841), Elena Lucarini (5326928), Serena Boccella (331854), Carmen Parisio (9395492), Grazia Graziani (111563), Laura Micheli (256012), Tommaso Mello (677155), Alessandra Toti (9395495)   +14 more
core   +1 more source

hSulf-1 gene exhibits anticancer efficacy through negatively regulating VEGFR-2 signaling in human cancers. [PDF]

PLoS ONE, 2011
BACKGROUND: Human sulfatase 1 (hSulf-1) is a heparin-degrading endosulfatase that desulfates cell surface heparan sulfate proteoglycans (HSPGs) in extracellular matrix and negatively modulates heparin-binding growth factor and cytokine signaling in cell ...
Weidan Ji, Jiahe Yang, Duanming Wang, Lu Cao, Weifeng Tan, Haihua Qian, Bin Sun, Qijun Qian, Zhengfeng Yin, Mengchao Wu, Changqing Su   +10 more
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Additional file 3 of VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody

, 2021
Additional file 3: Figure S2. Hypersensitivity-induced by VEGF-A family members is not due to the interaction with VEGFR-2. The response to a thermal stimulus (Cold plate test) was recorded after intrathecal infusion (30 ng) of (a) VEGF165b (n=5), (b ...
Lorenzo Di Cesare Mannelli (600627), Sabatino Maione (140730), Pedro Miguel Lacal (11567064), Carla Ghelardini (600626), Paola Failli (443253), Alessia Vona (11567061), Flavia Ricciardi (6590378), Alessandra Pacini (748841), Elena Lucarini (5326928), Serena Boccella (331854), Carmen Parisio (9395492), Grazia Graziani (111563), Laura Micheli (256012), Tommaso Mello (677155), Alessandra Toti (9395495)   +14 more
core   +1 more source

Unlocking Doors without Keys: Activation of Src by Truncated C-terminal Intracellular Receptor Tyrosine Kinases Lacking Tyrosine Kinase Activity

Cells, 2014
One of the best examples of the renaissance of Src as an open door to cancer has been the demonstration that just five min of Src activation is sufficient for transformation and also for induction and maintenance of cancer stem cells [1].
Belén Mezquita, Pau Mezquita, Montserrat Pau, Jovita Mezquita, Cristóbal Mezquita   +4 more
doaj   +1 more source

The anti-vascular endothelial growth factor receptor-1 monoclonal antibody D16F7 inhibits invasiveness of human glioblastoma and glioblastoma stem cells

Journal of Experimental & Clinical Cancer Research, 2017
Background Glioblastoma (GBM) is a highly migratory, invasive, and angiogenic brain tumor. Like vascular endothelial growth factor-A (VEGF-A), placental growth factor (PlGF) promotes GBM angiogenesis. VEGF-A is a ligand for both VEGF receptor-1 (VEGFR-1)
Maria Grazia Atzori, Lucio Tentori, Federica Ruffini, Claudia Ceci, Lucia Lisi, Elena Bonanno, Manuel Scimeca, Eskil Eskilsson, Thomas Daubon, Hrvoje Miletic, Lucia Ricci Vitiani, Roberto Pallini, Pierluigi Navarra, Rolf Bjerkvig, Stefania D’Atri, Pedro Miguel Lacal, Grazia Graziani   +16 more
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In Silico Evaluation of Interactions of Triterpenes in Momordica charantia on Proteins Involved in Angiogenesis

Proceedings, 2019
Angiogenesis is important process that play active role in tumorigenesis. VEGFR-1, a member of the tyrosine kinase receptor family, is known as the receptor for VEGF ligands in tumor cells.
Büşra Sevim, Onur Eroğlu
doaj   +1 more source

Vascular Endothelial Growth Factor Receptor-1 Expression in Breast Cancer and Its Correlation to Vascular Endothelial Growth Factor A

International Journal of Breast Cancer, 2013
VEGF-A is the most potent angiogenic factor in tumour angiogenesis. Its effects are mediated via two receptors VEGFR-1 and VEGFR-2. Primary aim of our study was to examine the expression of VEGFR-1 in breast cancer and its correlation to VEGF expression,
Nahida Srabovic, Zlata Mujagic, Jasminka Mujanovic-Mustedanagic, Adaleta Softic, Zdeno Muminovic, Adi Rifatbegovic, Lejla Begic   +6 more
doaj   +1 more source