Results 21 to 30 of about 29,745,998 (266)

EXPRESSION OF THE VASCULAR ENDOTHELIAL GROWTH FACTOR AND ITS RECEPTORS (VEGFR-1 AND VEGFR-2) IN PRIMARY TUMOR CELLS IN PATIENTS WITH RENAL CANCER

Сибирский онкологический журнал, 2021
Purpose: to study the expression of vascular endothelial growth factor (vegf-a) and its receptors (vegfr-1 and vegfr-2) in renal cell carcinoma (rcc) cells and assess the effect of the expression levels of these markers on the tumor characteristics and ...
D. A. Khochenkov, M. I. Volkova, I. V. Timofeev, A. S. Olshanskaya, Yu. A. Khochenkova, E. Sh. Solomko, S. A. Ashuba, V. B. Matveev   +7 more
doaj   +1 more source

Establishment of an oral squamous cell carcinoma cell line expressing vascular endothelial growth factor a and its two receptors

Journal of Dental Sciences, 2022
Background/purpose: Vascular endothelial growth factor receptor (VEGFR) expression in oral squamous cell carcinoma (OSCC) promotes tumor growth through both autocrine and paracrine signaling.
Hanako Araki-Maeda, Mutsuki Kawabe, Yuji Omori, Koji Yamanegi, Kazunari Yoshida, Kyohei Yoshikawa, Kazuki Takaoka, Kazuma Noguchi, Yoshiro Nakano, Hiromitsu Kishimoto   +9 more
doaj   +1 more source

Vascular endothelial growth factor receptor-1 activation promotes migration and invasion of breast cancer cells through epithelial-mesenchymal transition. [PDF]

PLoS ONE, 2013
Vascular endothelial growth factor receptor-1 (VEGFR-1 or Flt-1), a tyrosine kinase receptor, is highly expressed in breast cancer tissues, but near absent in normal breast tissue.
Qian Ning, Caigang Liu, Lei Hou, Min Meng, Xiaojin Zhang, Minna Luo, Shan Shao, Xiaoxiao Zuo, Xinhan Zhao   +8 more
doaj   +1 more source

Structural Basis of Lymphangiogenic Receptor VEGFR-3 Activation Mediated by Distinctive Clustering of the Ligand-Receptor Complex. [PDF]

Adv Sci (Weinh)
VEGF‐C and its receptor VEGFR‐3 are critical for lymphangiogenesis. Cryo‐EM structures of the VEGFR‐3/VEGF‐C ectodomain complex reveal a canonical 2:2 ligand–receptor hetero‐tetramer that further assembles into higher‐order clusters beyond simple receptor dimerization.
Cho R, Ahn J, Yang J, Lee DS, Hong G, Lee S, Kim HM.   +6 more
europepmc   +2 more sources

VEGFR-2 blockade induces tumor T cell infiltration.

, 2022
MC38 tumor bearing mice were treated with 40mg/kg Rat IgG, MF1 (anti-VEGFR-1), DC101 (anti-VEGFR-2) and mF4-31C1 (VEGFR-3) at a single dose, and then tumors were collected on day 14.
Thompson N. Doman (12263590), Ruslan Novosiadly (5156267), Yanxia Li (436765), Erik R. Rasmussen (13113500), Michael Kalos (5156288), Manisha Brahmachary (67743), Bronislaw Pytowski (13113503), Ivan Inigo (2698249), Nelusha Amaladas (13113491), Marguerita O’Mahony (13113494), Gerald Hall (5156303), David A. Schaer (13113506), Oscar Puig (155433), Qi Li (67548), Jason R. Manro (13113497)   +14 more
core   +1 more source

GM-CSF Promotes Neutrophil PD-L1 Expression Through the VEGFR-2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma. [PDF]

Adv Sci (Weinh)
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Zhu F, You Y, Zhang Y, Dai Y, Zhou X, Fu Y, Lu X, Huang Y, Zhou Z, Xia R, Ju W, Yuan Z, Zhong L, Zhao T.   +13 more
europepmc   +2 more sources

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Prognostic roles of cross-talk between peritumoral hepatocytes and stromal cells in hepatocellular carcinoma involving peritumoral VEGF-C, VEGFR-1 and VEGFR-3. [PDF]

PLoS ONE, 2013
BACKGROUND: Peritumoral liver tissue could play a potential role in hepatocellular carcinoma (HCC) progression and patient survival via angiogenesis- and lymphangiogensis-related factors.
Peng-Yuan Zhuang, Jun Shen, Xiao-Dong Zhu, Lu Lu, Lu Wang, Zhao-You Tang, Hui-Chuan Sun   +6 more
doaj   +1 more source

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

VEGF family members : modulators of tumor angiogenesis and lymphangiogenesis [PDF]

, 2006
Members of the vascular endothelial growth factor (VEGF) family and their receptors (VEGFR) play an essential role in the development and maintenance of the blood and lymphatic vasculature.
Kopfstein, Lucie
core   +1 more source