Results 21 to 30 of about 21,287,561 (278)

Placental Pathology and Placental Growth Factor (PlGF)/Vascular Endothelial Growth Factor Receptor-1 (VEGFR-1) Pathway Expression Evaluation in Fetal Congenital Heart Defects [PDF]

Life
The heart and placenta have simultaneous embryologic development, the interactions between the two organs representing the heart–placental axis. They both share key developmental pathways, one of which involves the placental growth factor (PlGF) and its ...
Alexandru Cristian Bolunduț, Ximena Maria Mureșan, Rada Teodora Suflețel, Lavinia Patricia Mocan, Simina Pîrv, Sergiu Șușman, Carmen Mihaela Mihu   +6 more
doaj   +2 more sources

VEGFR-1 Regulates EGF-R to Promote Proliferation in Colon Cancer Cells [PDF]

International Journal of Molecular Sciences, 2019
The relationship between epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) pathways in tumor growth is well established. EGF induces VEGF production in cancer cells, and the paracrine VEGF activates vascular endothelial cells to promote tumor angiogenesis and thus supports tumor cell growth in an angiogenesis-dependent manner.
Hikaru Nagano, Chisato Tomida, Naoko Yamagishi, Shigetada Teshima-Kondo   +3 more
openaire   +3 more sources

Ventilation-induced changes correlate to pulmonary vascular response and VEGF, VEGFR-1/2, and eNOS expression in the rat model of postnatal hypoxia [PDF]

Brazilian Journal of Medical and Biological Research, 2018
Neonatal asphyxia occurs due to reduction in oxygen supply to vital organs in the newborn. Rapid restoration of oxygen to the lungs after a long period of asphyxia can cause lung injury and decline of respiratory function, which result from the activity ...
R.L. Figueira, F.L. Gonçalves, A.R. Prado, M.C. Ribeiro, K.M. Costa, O. Castro e Silva, L. Sbragia   +6 more
doaj   +2 more sources

High Expression of Vascular Endothelial Growth Factor Receptor-1 (VEGFR-1) is Highly Correlated with Eclampsia

Indonesian Journal of Obstetrics and Gynecology, 2012
Objectives: To understand the expression of placental vascular endothelial growth factor receptor (VEGFR-1) in severe preeclampsia with complication (eclampsia and HELLP syndrome). Methods: The study was an observational study with cross sectional design,
Efendi Lukas
doaj   +3 more sources

Correction: VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody [PDF]

Journal of Experimental & Clinical Cancer Research
Laura Micheli, Carmen Parisio, Elena Lucarini, Alessia Vona, Alessandra Toti, Alessandra Pacini, Tommaso Mello, Serena Boccella, Flavia Ricciardi, Sabatino Maione, Grazia Graziani, Pedro Miguel Lacal, Paola Failli, Carla Ghelardini, Lorenzo Di Cesare Mannelli   +14 more
openaire   +3 more sources

VEGFR-1 blockade disrupts peri-implantation decidual angiogenesis and macrophage recruitment

Vascular Cell, 2014
Background: Angiogenesis and macrophage recruitment to the uterus are key features of uterine decidualization; the progesterone-mediated uterine changes that allow for embryo implantation and initiation of pregnancy. In the current study, we characterized the expression of vascular endothelial growth factor receptor-1 (VEGFR-1) in macrophages and ...
Douglas, Nataki C., Zimmermann, Ralf C., Tan, Qian, Sullivan-Pyke, Chantae, Sauer, Mark V., Kitajewski, Jan K., Shawber, Carrie   +6 more
openaire   +6 more sources

Synthesis, Characterization, Antioxidant Evaluation, Cytotoxicity Studies, and Molecular Docking of Novel Sulfonamide Derivatives. [PDF]

J Biochem Mol Toxicol
A series of novel sulfonamide derivatives (4a–i) were synthesized and characterized. Compound 4d showed significant antioxidant activity, while compounds 4g, 4h, and 4i exhibited high cytotoxicity against ovarian and prostate cancer cells, particularly 4h with a log IC50 of 1.343 µg/mL.
Bouraoui O, Şekerci G, Mesbah K, Ezugwu JA, Benkiniouar R, Tekin S, Küçükbay F, Boulebd H, Küçükbay H.   +8 more
europepmc   +2 more sources

VEGFR-2 blockade induces tumor T cell infiltration.

, 2022
MC38 tumor bearing mice were treated with 40mg/kg Rat IgG, MF1 (anti-VEGFR-1), DC101 (anti-VEGFR-2) and mF4-31C1 (VEGFR-3) at a single dose, and then tumors were collected on day 14.
Thompson N. Doman (12263590), Ruslan Novosiadly (5156267), Yanxia Li (436765), Erik R. Rasmussen (13113500), Michael Kalos (5156288), Manisha Brahmachary (67743), Bronislaw Pytowski (13113503), Ivan Inigo (2698249), Nelusha Amaladas (13113491), Marguerita O’Mahony (13113494), Gerald Hall (5156303), David A. Schaer (13113506), Oscar Puig (155433), Qi Li (67548), Jason R. Manro (13113497)   +14 more
core   +1 more source

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source