Results 41 to 50 of about 21,287,561 (278)

VEGFR-1–Selective VEGF Homologue PlGF Is Arteriogenic [PDF]

Circulation Research, 2003
Two signaling receptors for vascular endothelial growth factor (VEGF) in the vasculature are known with not yet well-understood roles in collateral vessel growth (arteriogenesis). In this study, we examined the involvement of the two VEGF receptors in arteriogenesis.
Frederic, Pipp, Matthias, Heil, Katja, Issbrücker, Tibor, Ziegelhoeffer, Sandra, Martin, Joop, van den Heuvel, Herbert, Weich, Borja, Fernandez, Gershon, Golomb, Peter, Carmeliet, Wolfgang, Schaper, Matthias, Clauss   +11 more
openaire   +2 more sources

Unlocking Doors without Keys: Activation of Src by Truncated C-terminal Intracellular Receptor Tyrosine Kinases Lacking Tyrosine Kinase Activity

Cells, 2014
One of the best examples of the renaissance of Src as an open door to cancer has been the demonstration that just five min of Src activation is sufficient for transformation and also for induction and maintenance of cancer stem cells [1].
Belén Mezquita, Pau Mezquita, Montserrat Pau, Jovita Mezquita, Cristóbal Mezquita   +4 more
doaj   +1 more source

Altered expression of vascular endothelial growth factor, vascular endothelial growth factor receptor-1, vascular endothelial growth factor receptor-2, and Soluble Fms-like Tyrosine Kinase-1 in peripheral blood mononuclear cells from normal and preeclamptic pregnancies

Chinese Journal of Physiology, 2019
Preeclampsia (PE) is the leading cause of maternal and fetal morbidity and mortality. It complicates around 2%–10% pregnancies worldwide due to imbalance between proangiogenic and anti-angiogenic factors, leading to incomplete placentation, ischemia, and
Zaima Ali, Saba Khaliq, Saima Zaki, Hafiz Usman Ahmad, Khalid Pervaiz Lone   +4 more
doaj   +1 more source

Vascular Endothelial Growth Factor Receptor-1 Expression in Breast Cancer and Its Correlation to Vascular Endothelial Growth Factor A

International Journal of Breast Cancer, 2013
VEGF-A is the most potent angiogenic factor in tumour angiogenesis. Its effects are mediated via two receptors VEGFR-1 and VEGFR-2. Primary aim of our study was to examine the expression of VEGFR-1 in breast cancer and its correlation to VEGF expression,
Nahida Srabovic, Zlata Mujagic, Jasminka Mujanovic-Mustedanagic, Adaleta Softic, Zdeno Muminovic, Adi Rifatbegovic, Lejla Begic   +6 more
doaj   +1 more source

Discovery of new nicotinamides as apoptotic VEGFR-2 inhibitors: virtual screening, synthesis, anti-proliferative, immunomodulatory, ADMET, toxicity, and molecular dynamic simulation studies

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
A library of modified VEGFR-2 inhibitors was designed as VEGFR-2 inhibitors. Virtual screening was conducted for the hypothetical library using in silico docking, ADMET, and toxicity studies. Four compounds exhibited high in silico affinity against VEGFR-
Reda G. Yousef, Albaraa Ibrahim, Mohamed M. Khalifa, Wagdy M. Eldehna, Ibraheem M. M. Gobaara, Ahmed B. M. Mehany, Eslam B. Elkaeed, Aisha A. Alsfouk, Ahmed M. Metwaly, Ibrahim H. Eissa   +9 more
doaj   +1 more source

In Silico Evaluation of Interactions of Triterpenes in Momordica charantia on Proteins Involved in Angiogenesis

Proceedings, 2019
Angiogenesis is important process that play active role in tumorigenesis. VEGFR-1, a member of the tyrosine kinase receptor family, is known as the receptor for VEGF ligands in tumor cells.
Büşra Sevim, Onur Eroğlu
doaj   +1 more source

The Effects of VEGF Signal Pathway on Etiopathogenesis and AntiVEGF Treatments in Childhood Cancers

Çocuk Dergisi, 2023
Vascular endothelial growth factor (VEGF) is the most physiologically and pathologically potent angiogenic factor that acts directly on endothelial cells.
Ali Kazdal, Meryem Ertuğrul, Selma Söylemez, Hikmet Gülşah Tanyıldız   +3 more
doaj   +1 more source

The structural and functional characterization of the extracellular domain of vascular endothelial growth factor receptors : their role in receptor activation and use as therapeutic targets [PDF]

, 2012
: The vascular endothelial growth factor (VEGF) family plays key roles in the development of the blood and lymphatic vasculature. Five members, VEGF A, B, -C, -D, and PlGF can be found in the human body.
Stuttfeld, Edward
core   +1 more source

Single nucleotide polymorphisms: rs833061, rs699947, and rs35569394, and the expression of the vascular endothelial growth factor gene in Moroccan patients with lung cancer [PDF]

Exploration of Medicine
Aim: Angiogenesis is a universal hallmark of all cancers involving a variety of proteins including vascular endothelial growth factor (VEGF). Extensive studies have explored the potential implications of single nucleotide polymorphisms (SNPs) within VEGF-
Younes El Founini, Sara Hafidi, Hind Dehbi, Mohammed Attaleb, Mehdi Karkouri, Souheil Boubia, Mohammed Ridai, Fadila Guessous, Mohammed El Mzibri, Imane Chaoui   +9 more
doaj   +1 more source

Gene expression of VEGFR–1 and VEGFR–2 in HD1 and HD2.

, 2022
Median and standard error of gene expression of VEGFR–1 and VEGFR–2 at all points of investigation in native ECs of HD1 and HD2 are shown.
Christina Herre (12475755), Arpenik Nshdejan (12475758), Giuliano Mario Corte (6635627), Mahtab Bahramsoltani (12475761), Robert Klopfleisch (456698)   +4 more
core   +1 more source