Results 41 to 50 of about 29,745,998 (266)

Single nucleotide polymorphisms: rs833061, rs699947, and rs35569394, and the expression of the vascular endothelial growth factor gene in Moroccan patients with lung cancer [PDF]

Exploration of Medicine
Aim: Angiogenesis is a universal hallmark of all cancers involving a variety of proteins including vascular endothelial growth factor (VEGF). Extensive studies have explored the potential implications of single nucleotide polymorphisms (SNPs) within VEGF-
Younes El Founini, Sara Hafidi, Hind Dehbi, Mohammed Attaleb, Mehdi Karkouri, Souheil Boubia, Mohammed Ridai, Fadila Guessous, Mohammed El Mzibri, Imane Chaoui   +9 more
doaj   +1 more source

Discovery of new nicotinamides as apoptotic VEGFR-2 inhibitors: virtual screening, synthesis, anti-proliferative, immunomodulatory, ADMET, toxicity, and molecular dynamic simulation studies

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
A library of modified VEGFR-2 inhibitors was designed as VEGFR-2 inhibitors. Virtual screening was conducted for the hypothetical library using in silico docking, ADMET, and toxicity studies. Four compounds exhibited high in silico affinity against VEGFR-
Reda G. Yousef, Albaraa Ibrahim, Mohamed M. Khalifa, Wagdy M. Eldehna, Ibraheem M. M. Gobaara, Ahmed B. M. Mehany, Eslam B. Elkaeed, Aisha A. Alsfouk, Ahmed M. Metwaly, Ibrahim H. Eissa   +9 more
doaj   +1 more source

Structure of the full-length VEGFR-1 extracellular domain in complex with VEGF-A [PDF]

Acta Crystallographica Section A Foundations and Advances, 2016
SUMMARY Vascular Endothelial Growth Factors (VEGFs) regulate blood and lymph vessel development upon activation of three receptor tyrosine kinases (RTKs), VEGFR-1, −2, and −3. Partial structures of VEGFR/VEGF complexes based on single particle electron microscopy, small angle X-ray scattering, and X-ray crystallography revealed the ...
Markovic-Mueller, Sandra, Stuttfeld, Edward, Asthana, Mayanka, Weinert, Tobias, Bliven, Spencer, Goldie, Kenneth N., Kisko, Kaisa, Capitani, Guido, Ballmer-Hofer, Kurt   +8 more
openaire   +6 more sources

The structural and functional characterization of the extracellular domain of vascular endothelial growth factor receptors : their role in receptor activation and use as therapeutic targets [PDF]

, 2012
: The vascular endothelial growth factor (VEGF) family plays key roles in the development of the blood and lymphatic vasculature. Five members, VEGF A, B, -C, -D, and PlGF can be found in the human body.
Stuttfeld, Edward
core   +1 more source

Altered expression of vascular endothelial growth factor, vascular endothelial growth factor receptor-1, vascular endothelial growth factor receptor-2, and Soluble Fms-like Tyrosine Kinase-1 in peripheral blood mononuclear cells from normal and preeclamptic pregnancies

Chinese Journal of Physiology, 2019
Preeclampsia (PE) is the leading cause of maternal and fetal morbidity and mortality. It complicates around 2%–10% pregnancies worldwide due to imbalance between proangiogenic and anti-angiogenic factors, leading to incomplete placentation, ischemia, and
Zaima Ali, Saba Khaliq, Saima Zaki, Hafiz Usman Ahmad, Khalid Pervaiz Lone   +4 more
doaj   +1 more source

The Effects of VEGF Signal Pathway on Etiopathogenesis and AntiVEGF Treatments in Childhood Cancers

Çocuk Dergisi, 2023
Vascular endothelial growth factor (VEGF) is the most physiologically and pathologically potent angiogenic factor that acts directly on endothelial cells.
Ali Kazdal, Meryem Ertuğrul, Selma Söylemez, Hikmet Gülşah Tanyıldız   +3 more
doaj   +1 more source

The Prognostic Value of the Combination of Low VEGFR-1 and High VEGFR-2 Expression in Endothelial Cells of Colorectal Cancer. [PDF]

Int J Mol Sci, 2018
Research on tumor angiogenesis has mainly focused on the vascular endothelial growth factor (VEGF) family and on methods to block its actions. However, reports on VEGF receptor (VEGFR) expression in tumor-associated endothelial cells (ECs) are limited ...
D'Haene N, Koopmansch C, Van Eycke YR, Hulet F, Allard J, Bouri S, Rorive S, Remmelink M, Decaestecker C, Maris C, Salmon I.   +10 more
europepmc   +2 more sources

VEGFR-1–Selective VEGF Homologue PlGF Is Arteriogenic [PDF]

Circulation Research, 2003
Two signaling receptors for vascular endothelial growth factor (VEGF) in the vasculature are known with not yet well-understood roles in collateral vessel growth (arteriogenesis). In this study, we examined the involvement of the two VEGF receptors in arteriogenesis.
Frederic, Pipp, Matthias, Heil, Katja, Issbrücker, Tibor, Ziegelhoeffer, Sandra, Martin, Joop, van den Heuvel, Herbert, Weich, Borja, Fernandez, Gershon, Golomb, Peter, Carmeliet, Wolfgang, Schaper, Matthias, Clauss   +11 more
openaire   +2 more sources

Differential expression of Vegfr-2 and its soluble form in preeclampsia.

PLoS ONE, 2012
BackgroundSeveral studies have suggested that the main features of preeclampsia (PE) are consequences of endothelial dysfunction related to excess circulating anti-angiogenic factors, most notably, soluble sVEGFR-1 (also known as sFlt-1) and soluble ...
Carine Munaut, Sophie Lorquet, Christel Pequeux, Capucine Coulon, Jeanne Le Goarant, Frédéric Chantraine, Agnès Noël, Frédéric Goffin, Vassilis Tsatsaris, Damien Subtil, Jean-Michel Foidart   +10 more
doaj   +1 more source

Gene expression of VEGFR–1 and VEGFR–2 in HD1 and HD2.

, 2022
Median and standard error of gene expression of VEGFR–1 and VEGFR–2 at all points of investigation in native ECs of HD1 and HD2 are shown.
Christina Herre (12475755), Arpenik Nshdejan (12475758), Giuliano Mario Corte (6635627), Mahtab Bahramsoltani (12475761), Robert Klopfleisch (456698)   +4 more
core   +1 more source