Results 61 to 70 of about 21,287,561 (278)

VEGFR-1 Expressed by Malignant Melanoma-Initiating Cells Is Required for Tumor Growth [PDF]

Cancer Research, 2011
Abstract Melanoma growth is driven by malignant melanoma-initiating cells (MMIC) identified by expression of the ATP-binding cassette (ABC) member ABCB5. ABCB5+ melanoma subpopulations have been shown to overexpress the vasculogenic differentiation markers CD144 (VE-cadherin) and TIE1 and are associated with CD31− vasculogenic mimicry
Natasha Y, Frank, Tobias, Schatton, Soo, Kim, Qian, Zhan, Brian J, Wilson, Jie, Ma, Karim R, Saab, Veronika, Osherov, Hans R, Widlund, Martin, Gasser, Ana-Maria, Waaga-Gasser, Thomas S, Kupper, George F, Murphy, Markus H, Frank   +13 more
openaire   +2 more sources

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

VEGFR-1 Pseudogene Expression and Regulatory Function in Human Colorectal Cancer Cells [PDF]

Molecular Cancer Research, 2015
Abstract A large number of pseudogenes have been found to be transcribed in human cancers. However, only a few pseudogenes are functionally characterized. Here, we identified a transcribed pseudogene of VEGFR1, or fms-related tyrosine kinase 1 (FLT1), in human colorectal cancer cells.
Xiangcang, Ye, Fan, Fan, Rajat, Bhattacharya, Seth, Bellister, Delphine R, Boulbes, Rui, Wang, Ling, Xia, Cristina, Ivan, Xiaofeng, Zheng, George A, Calin, Jing, Wang, Xiongbin, Lu, Lee M, Ellis   +12 more
openaire   +2 more sources

The role of heterodimerization between VEGFR-1 and VEGFR-2 in the regulation of endothelial cell homeostasis [PDF]

, 2012
VEGF-A activity is tightly regulated by ligand and receptor availability. Here we investigate the physiological function of heterodimers between VEGF receptor-1 (VEGFR-1; Flt-1) and VEGFR-2 (KDR; Flk-1) (VEGFR(1-2)) in endothelial cells with a synthetic ...
Cudmore, Melissa J., Gu, Yuchun, Barleon, Bernhard, Hewett, Peter W, Al-Ani, Bahjat, Newby, David E., Cudmore, Melissa J, Fujisawa, Takeshi; id_orcid, Weich, Herbert, Hewett, Peter, Newby, David E, Sissaoui, Samir, Ahmed, Asif, Hewett, Peter W., Wang, Ke-Qing, Cai, Meng, Miller, Mark R., Ramma, Wenda, Fujisawa, Takeshi, Ahmad, Shakil, Miller, Mark R, Ma, Bin   +21 more
core   +1 more source

Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang, Baoshuai Liang, Liangmin Fu, Weiliang Deng, Yuyan Jiang, Weiping Xu, Jinwei Chen, Ya Zhou, Ke Wu, Jiaguo Huang   +9 more
wiley   +1 more source

Modulation of Receptor Tyrosine Kinase Activity through Alternative Splicing of Ligands and Receptors in the VEGF-A/VEGFR Axis

Cells, 2019
Vascular endothelial growth factor A (VEGF-A) signaling is essential for physiological and pathological angiogenesis. Alternative splicing of the VEGF-A pre-mRNA gives rise to a pro-angiogenic family of isoforms with a differing number of amino acids ...
Megan Stevens, Sebastian Oltean
doaj   +1 more source

A Bone Marrow–Mimetic Hydrogel Enables Dual‐Phase Hemostasis and Vascularized Osteogenesis for Cranial Defects

Advanced Science, EarlyView.
A biomimetic, fiber‐reinforced hydrogel (FE‐PDA@Fib/Gel‐TG) that enables dual‐phase cranial defect repair. The system provides: instant hemostasis in the early stage, and sustained co‐delivery of pro‐angiogenic and osteogenic signals for synergistic vascularized bone regeneration.
Lingbin Che, Donghong Li, Huan Zhang, Tingting Xu, Juhan Li, Xuanzhou Chen, Louis D. Zhang, Shuguang Wang, Dianwen Song, Dongyong Sha   +9 more
wiley   +1 more source

Cytotoxicity of VEGF₁₂₁/rGel on vascular endothelial cells resulting in inhibition of angiogenesis is mediated via VEGFR-2

BMC Cancer, 2011
Background The fusion protein VEGF121/rGel composed of the growth factor VEGF121 and the plant toxin gelonin targets the tumor neovasculature and exerts impressive anti-vascular effects.
Hittelman Walter N, Cheung Lawrence H, Kim Sehoon, Xu Jing, Ramdas Latha, Gomez-Manzano Candelaria, Ran Sophia, Mohamedali Khalid A, Zhang Wei, Waltenberger Johannes, Thorpe Philip E, Rosenblum Michael G   +11 more
doaj   +1 more source

Silencing VEGFR-2 Hampers Odontoblastic Differentiation of Dental Pulp Stem Cells

Frontiers in Cell and Developmental Biology, 2021
Dental pulp stem cells (DPSCs) are a source of postnatal stem cells essential for maintenance and regeneration of dentin and pulp tissues. Previous in vivo transplantation studies have shown that DPSCs are able to give rise to odontoblast-like cells ...
Kajohnkiart Janebodin, Kajohnkiart Janebodin, Kajohnkiart Janebodin, Rakchanok Chavanachat, Aislinn Hays, Aislinn Hays, Aislinn Hays, Morayma Reyes Gil   +7 more
doaj   +1 more source

Additional file 1 of VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody

, 2021
Additional file 1: Table S1. List of antibodies used for immunohistochemistry and western blot assays.
Micheli, Laura, Parisio, Carmen, Lucarini, Elena, Vona, Alessia, Toti, Alessandra, Pacini, Alessandra, Mello, Tommaso, Boccella, Serena, Ricciardi, Flavia, Maione, Sabatino, Graziani, Grazia, Lacal, Pedro Miguel, Failli, Paola, Ghelardini, Carla, Di Cesare Mannelli, Lorenzo   +14 more
openaire   +1 more source