Results 61 to 70 of about 29,745,998 (266)

LRG1 Drives Pathological Angiogenesis by Disrupting Neutrophil Mitochondrial Homeostasis in Bladder Cancer

Advanced Science, EarlyView.
In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen, Cong Zhang, Song Xue, Yuan Zeng, Haochen Cui, Chenfei Wang, Jiayi Feng, Lei Yan, Yuanwei Zang   +8 more
wiley   +1 more source

Modulation of Receptor Tyrosine Kinase Activity through Alternative Splicing of Ligands and Receptors in the VEGF-A/VEGFR Axis

Cells, 2019
Vascular endothelial growth factor A (VEGF-A) signaling is essential for physiological and pathological angiogenesis. Alternative splicing of the VEGF-A pre-mRNA gives rise to a pro-angiogenic family of isoforms with a differing number of amino acids ...
Megan Stevens, Sebastian Oltean
doaj   +1 more source

The role of heterodimerization between VEGFR-1 and VEGFR-2 in the regulation of endothelial cell homeostasis [PDF]

, 2012
VEGF-A activity is tightly regulated by ligand and receptor availability. Here we investigate the physiological function of heterodimers between VEGF receptor-1 (VEGFR-1; Flt-1) and VEGFR-2 (KDR; Flk-1) (VEGFR(1-2)) in endothelial cells with a synthetic ...
Cudmore, Melissa J., Gu, Yuchun, Barleon, Bernhard, Hewett, Peter W, Al-Ani, Bahjat, Newby, David E., Cudmore, Melissa J, Fujisawa, Takeshi; id_orcid, Weich, Herbert, Hewett, Peter, Newby, David E, Sissaoui, Samir, Ahmed, Asif, Hewett, Peter W., Wang, Ke-Qing, Cai, Meng, Miller, Mark R., Ramma, Wenda, Fujisawa, Takeshi, Ahmad, Shakil, Miller, Mark R, Ma, Bin   +21 more
core   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

Cytotoxicity of VEGF₁₂₁/rGel on vascular endothelial cells resulting in inhibition of angiogenesis is mediated via VEGFR-2

BMC Cancer, 2011
Background The fusion protein VEGF121/rGel composed of the growth factor VEGF121 and the plant toxin gelonin targets the tumor neovasculature and exerts impressive anti-vascular effects.
Hittelman Walter N, Cheung Lawrence H, Kim Sehoon, Xu Jing, Ramdas Latha, Gomez-Manzano Candelaria, Ran Sophia, Mohamedali Khalid A, Zhang Wei, Waltenberger Johannes, Thorpe Philip E, Rosenblum Michael G   +11 more
doaj   +1 more source

Silencing VEGFR-2 Hampers Odontoblastic Differentiation of Dental Pulp Stem Cells

Frontiers in Cell and Developmental Biology, 2021
Dental pulp stem cells (DPSCs) are a source of postnatal stem cells essential for maintenance and regeneration of dentin and pulp tissues. Previous in vivo transplantation studies have shown that DPSCs are able to give rise to odontoblast-like cells ...
Kajohnkiart Janebodin, Kajohnkiart Janebodin, Kajohnkiart Janebodin, Rakchanok Chavanachat, Aislinn Hays, Aislinn Hays, Aislinn Hays, Morayma Reyes Gil   +7 more
doaj   +1 more source

Additional file 8 of VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody

, 2021
Additional file 8: Table S2. Hole Board test. (DOCX 17 kb). The Hole board test was performed 3, 5 and 9 days after the beginning of oxaliplatin treatment (n=5). Each value represents the mean ± SEM. **P<0.01 vs vehicle + vehicle treated animals. The analysis of variance was performed by one-way ANOVA.
Micheli, Laura, Parisio, Carmen, Lucarini, Elena, Vona, Alessia, Toti, Alessandra, Pacini, Alessandra, Mello, Tommaso, Boccella, Serena, Ricciardi, Flavia, Maione, Sabatino, Graziani, Grazia, Lacal, Pedro Miguel, Failli, Paola, Ghelardini, Carla, Di Cesare Mannelli, Lorenzo   +14 more
openaire   +1 more source

Expression Pattern of Angiogenic Factors in Healthy Heart in Response to Physical Exercise Intensity

Frontiers in Physiology, 2019
Recently, many studies showing the regeneration potential of both cardiac and hematopoietic stem cells in adult heart following injury were definitively retracted by the literature.
Marianna Bellafiore, Giuseppe Battaglia, Antonino Bianco, Antonio Palma   +3 more
doaj   +1 more source

Additional file 1 of VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody

, 2021
Additional file 1: Table S1. List of antibodies used for immunohistochemistry and western blot assays.
Micheli, Laura, Parisio, Carmen, Lucarini, Elena, Vona, Alessia, Toti, Alessandra, Pacini, Alessandra, Mello, Tommaso, Boccella, Serena, Ricciardi, Flavia, Maione, Sabatino, Graziani, Grazia, Lacal, Pedro Miguel, Failli, Paola, Ghelardini, Carla, Di Cesare Mannelli, Lorenzo   +14 more
openaire   +1 more source

Lv-VEGFR-10-Ig is required for BC transfating.

, 2019
(A) MO knockdown strategy. Following the approach of Duloquin and coworkers [9], an MO was directed at the exon 2/intron 2 splice junction of the Lv-vegfr-10-Ig primary transcript. (B) RT-PCR analysis of morphant embryos. The Lv-vegfr-10-Ig MO produced a
Ashrifia Adomako-Ankomah (7401002), Charles A. Ettensohn (5062514)   +1 more
core   +1 more source