Results 71 to 80 of about 21,287,561 (278)
Advanced Science, EarlyView.IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng +7 more
wiley +1 more source
Lv-VEGFR-10-Ig is required for BC transfating.
, 2019 (A) MO knockdown strategy. Following the approach of Duloquin and coworkers [9], an MO was directed at the exon 2/intron 2 splice junction of the Lv-vegfr-10-Ig primary transcript. (B) RT-PCR analysis of morphant embryos. The Lv-vegfr-10-Ig MO produced a
Ashrifia Adomako-Ankomah (7401002) +1 more
core +1 more source
VEGFR–1 and VEGFR–2 expression in native ECs of HD1 and HD2.
, 2022 Median and standard error was evaluated at day 1, 5, 15, 25 and 50 of cultivation. By using Mann–Whitney U test for unpaired data, it was shown that VEGFR–2 was higher expressed than VEGFR–1 at every point of investigation in both cultures (p (DOCX)
Christina Herre (12475755) +4 more
core +1 more source
Advanced Science, EarlyView.ABSTRACT Vascularization remains a major obstacle in tissue engineering. Here, we introduce a bioprinting strategy to generate centimeter‐scale, self‐organizing “mother vessel” constructs from iPSC‐derived hiMPCs. By optimizing bioink composition, printing was accomplished in a single‐step approach. Within one week, hiMPCs differentiated into both CD31+
Leyla E. Dogan +5 more
wiley +1 more source
Expression Pattern of Angiogenic Factors in Healthy Heart in Response to Physical Exercise Intensity
Frontiers in Physiology, 2019 Recently, many studies showing the regeneration potential of both cardiac and hematopoietic stem cells in adult heart following injury were definitively retracted by the literature.
Marianna Bellafiore +3 more
doaj +1 more source
VEGFR-1 Activation-Induced MMP-9-Dependent Invasion in Hepatocellular Carcinoma [PDF]
Future Oncology, 2015 VEGFR-1 can promote invasion through epithelial-mesenchymal transition induction in hepatocellular carcinoma (HCC). This study aims to elucidate VEGFR-1 impact on proteolytic enzymes profile involved with invasion.The effect on cell invasion was evaluated by invasive and migration assays with and without VEGFR-1 activation.
Tao, Li +5 more
openaire +2 more sources
Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276
Advanced Science, EarlyView.WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan +10 more
wiley +1 more source
Advanced Science, EarlyView.This non‑enzymatic function of DHODH drives sunitinib resistance by competing with TRIM37 to block TRIM28 ubiquitination, thereby stabilizing TRIM28 and activating VEGFA transcription. Disrupting the DHODH–TRIM28 interaction with lisaftoclax restores drug sensitivity.
Shijie Qian +10 more
wiley +1 more source
Activation of VEGFR-1 and VEGFR-2 by UVA involves activation of PKC and SFK.
, 2013 (a) Western blotting detection of P-VEGFR-1 and P-VEGFR-2 in keratinocytes 12 h after treatment of 10 J/cm2 UVA with or without pre-incubation of Go6976 (0.5 µM), or rottlerin (5.0 µM) for 1 h. (b) The densitometric analysis of P-VEGFR-1 and P-VEGFR-2 in
Zhong-Fa Lu (285979) +5 more
core +1 more source
, 2021 Additional file 8: Table S2. Hole Board test. (DOCX 17 kb). The Hole board test was performed 3, 5 and 9 days after the beginning of oxaliplatin treatment (n=5). Each value represents the mean ± SEM. **P<0.01 vs vehicle + vehicle treated animals. The analysis of variance was performed by one-way ANOVA.
Micheli, Laura +14 more
openaire +1 more source