Results 81 to 90 of about 29,745,998 (266)

Knockdown of Lv-VEGFR-10-Ig in PMCs reduces their ability to suppress BC transfating.

, 2019
(A) Experimental design. The entire complement of PMCs was removed from a recipient embryo and replaced with 15–40 RITC-labeled PMCs from control or Lv-VEGFR-10-Ig morphant donor embryos.
Ashrifia Adomako-Ankomah (7401002), Charles A. Ettensohn (5062514)   +1 more
core   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

VEGF and VEGFR‐1 are coexpressed by epithelial and stromal cells of renal cell carcinoma [PDF]

Cancer, 2007
AbstractBACKGROUND.Tumor angiogenesis is a dynamic process that plays a major role in cancer progression. Vascular endothelial growth factor (VEGF) and its receptors play a pivotal role in angiogenesis. The expression of VEGF and its receptors VEGFR‐1 and VEGFR‐2 in renal cell carcinoma (RCC) was investigated in the perspective of anti‐VEGF treatments ...
Jacqueline, Rivet, Samia, Mourah, Hideyuki, Murata, Nicolas, Mounier, Helena, Pisonero, Pierre, Mongiat-Artus, Pierre, Teillac, Fabien, Calvo, Anne, Janin, Christine, Dosquet   +9 more
openaire   +2 more sources

A Cytosine‑Bulged (3+1) Hybrid G‑Quadruplex Formed by the Chicken DNA Replication Origin

Chemistry – A European Journal, EarlyView.
The first high‐resolution structure of an OGRE‐derived G‐quadruplex from the chicken β‐globin replication origin reveals an intramolecular three‐layer (3+1) hybrid fold with a cytosine bulge and an unprecedented 5'‐outer‐quartet anti guanine, creating a distinctive surface for molecular recognition.
Yingying You, Monica Ching Suen, Haitao Miao, Yanyan Geng, Rahman Ud Din, Mu Yuan, Qiang Xue, Xiaoting Li, Naining Xu, Zhihong Guo, Hon‐Ming Lam, Kwok‐Wai Lo, Changdong Liu, Guang Zhu   +13 more
wiley   +1 more source

VEGFR-1 Expressed by Malignant Melanoma-Initiating Cells Is Required for Tumor Growth [PDF]

Cancer Research, 2011
Abstract Melanoma growth is driven by malignant melanoma-initiating cells (MMIC) identified by expression of the ATP-binding cassette (ABC) member ABCB5. ABCB5+ melanoma subpopulations have been shown to overexpress the vasculogenic differentiation markers CD144 (VE-cadherin) and TIE1 and are associated with CD31− vasculogenic mimicry
Natasha Y, Frank, Tobias, Schatton, Soo, Kim, Qian, Zhan, Brian J, Wilson, Jie, Ma, Karim R, Saab, Veronika, Osherov, Hans R, Widlund, Martin, Gasser, Ana-Maria, Waaga-Gasser, Thomas S, Kupper, George F, Murphy, Markus H, Frank   +13 more
openaire   +2 more sources

Dissecting VEGFR-2 and VEGFR-3 function : VEGFR-3 mediates lymphangiogenic signals [PDF]

, 2002
ei ...
Veikkola, Tanja
core  

Time‐Dependent Bias and Prognostic Confounding in Exposure–Response Analysis of Targeted Therapies: Lessons from Sunitinib in Metastatic Renal Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Exposure–response (E–R) analyses of sunitinib in metastatic renal cell carcinoma (mRCC) have supported concentration‐guided dose escalation. However, such analyses may be biased when exposure metrics incorporate post‐baseline dose modifications, time‐varying apparent clearance, or baseline factors that influence both pharmacokinetics and clinical ...
Han Liu, Lena E. Friberg
wiley   +1 more source

Treatment with a VEGFR-2 antibody results in intra-tumor immune modulation and enhances anti-tumor efficacy of PD-L1 blockade in syngeneic murine tumor models

PLoS ONE, 2022
Prolonged activation of vascular endothelial growth factor receptor-2 (VEGFR-2) due to mis-regulation of the VEGF pathway induces aberrant blood vessel expansion, which supports growth and survival of solid tumors.
Yanxia Li, Nelusha Amaladas, Marguerita O’Mahony, Jason R. Manro, Ivan Inigo, Qi Li, Erik R. Rasmussen, Manisha Brahmachary, Thompson N. Doman, Gerald Hall, Michael Kalos, Ruslan Novosiadly, Oscar Puig, Bronislaw Pytowski, David A. Schaer   +14 more
doaj  

The functions and applications of A7R in anti-angiogenic therapy, imaging and drug delivery systems

Asian Journal of Pharmaceutical Sciences, 2019
Vascular endothelial growth factor receptor 2 (VEGFR-2) and neuropilin-1 (NRP-1) are two prominent antiangiogenic targets. They are highly expressed on vascular endothelial cells and some tumor cells.
Lu Lu, Hongyuan Chen, Dake Hao, Xinke Zhang, Fengshan Wang   +4 more
doaj   +1 more source

A Theobromine Derivative with Anticancer Properties Targeting VEGFR‐2: Semisynthesis, in silico and in vitro Studies

ChemistryOpen, 2023
A computer‐assisted drug design (CADD) approach was utilized to design a new acetamido‐N‐(para‐fluorophenyl)benzamide) derivative of the naturally occurring alkaloid, theobromine, (T‐1‐APFPB), following the pharmacophoric features of VEGFR‐2 inhibitors ...
Prof. Ibrahim H. Eissa, Reda G. Yousef, Dr. Hazem Elkady, Dr. Eslam B. Elkaeed, Dr. Aisha A. Alsfouk, Dr. Dalal Z. Husein, Ibrahim M. Ibrahim, Prof. Mohamed M. Radwan, Prof. Ahmed M. Metwaly   +8 more
doaj   +1 more source