Results 51 to 60 of about 29,745,998 (266)
Angewandte Chemie, EarlyView.Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee +5 more
wiley +2 more sources
The role of the FLT1 gene alternative splicing in the fetal growth retardation development
Acta Biomedica ScientificaBackground. Fetal growth restriction (FGR) is a major pregnancy complication often associated with placental dysfunction and angiogenic imbalance. The FLT1 gene encodes VEGFR-1, producing both membrane receptors and soluble isoforms (sFlt-1) through ...
M. M. Gavrilenko +5 more
doaj +1 more source
Mediating EGFR-TKI Resistance by VEGF/VEGFR Autocrine Pathway in Non-Small Cell Lung Cancer
Cells, 2022 NSCLC treatment includes targeting of EGFR with tyrosine kinase inhibitors (TKIs) such as Erlotinib; however, resistance to TKIs is commonly acquired through T790M EGFR mutations or overexpression of vascular endothelial growth factor receptor-2 (VEGFR-2)
Chike Osude +11 more
doaj +1 more source
Current Issues in Molecular Biology, 2022 Vascular endothelial growth factors (VEGFs) are important regulators of angiogenesis, neuroprotection, and neurogenesis. Studies have indicated the association of VEGF dysregulation with the development of neurodegenerative and cerebrovascular diseases ...
Anastasiya S. Babkina +7 more
doaj +1 more source
VEGFR-2 Expression in Glioblastoma Multiforme Depends on Inflammatory Tumor Microenvironment
International Journal of Inflammation, 2015 Glioblastoma multiforme (GBM) is one of the most angiogenic tumors. However, antiangiogenic therapy has not shown significant clinical efficacy. The aim of our study was to evaluate the impact of inflammatory tumor microenvironment on the expression of ...
Jana Jaal +10 more
doaj +1 more source
Lv-vegfr-10-Ig expression during BC transfating.
, 2019 (A) Control gastrula. Lv-vegfr-10-Ig is expressed at high levels by PMCs (arrow), as previously reported [9]. (B) PMC(−) embryo, 2 hpd. Expression of Lv-vegfr-10-Ig is evident in the invaginating vegetal plate (arrow), a region that includes presumptive ...
Ashrifia Adomako-Ankomah (7401002) +1 more
core +1 more source
Renal ischemia-reperfusion increases endothelial VEGFR-2 without increasing VEGF or VEGFR-1 expression [PDF]
, 2002 Renal ischemia-reperfusion increases endothelial VEGFR-2 without increasing VEGF or VEGFR-1 expression.BackgroundHypoxia is a potent stimulus to angiogenesis.
Stacker, Steven A. +6 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Expression and Significances of Contactin-1 in Human Gastric Cancer
Gastroenterology Research and Practice, 2013 Background. This study aimed at determining the relationship between vascular endothelial growth factor-C (VEGF-C), vascular endothelial growth factor receptor-3 (VEGFR-3), and contactin-1 (CNTN-1) expression in gastric cancer (GC ...
Ji-Wei Yu +10 more
doaj +1 more source
Advanced Science, EarlyView.A double‐layered shell‐core microneedle patch is developed to co‐deliver FOLFIRINOX, surufatinib, and anti‐PD‐1 for localized chemo‐immunotherapy of PDAC. This strategy achieves sustained tumor suppression, reduces metastasis, and reprograms the TME by enhancing CD8+ T‐cell infiltration and inhibiting Tregs and M2 macrophages infiltration, while ...
Tingting Kong +13 more
wiley +1 more source