Results 221 to 230 of about 21,287,561 (278)

IL-10 secretion by CD8 T cells orchestrates early NK cell recruitment and antitumor immunity after anti-VEGFR-2/PD-1 therapy. [PDF]

J Immunother Cancer
Geindreau M, Pignol C, Coënon L, Varin A, Racoeur C, Milian L, Roger N, Chalmin F, Vernet T, Alibert L, Bellaye PS, Thibaudin M, Louis C, Wicks I, Truntzer C, Boidot R, Paul C, Lamarthée B, Vegran F, Ghiringhelli F, Bruchard M.   +20 more
europepmc   +1 more source

Prospective Multicenter Observational Study of Anlotinib in Advanced Non‐Small Cell Lung Cancer: Real‐World Evidence From China

Thoracic Cancer, Volume 17, Issue 11, June 2026.
In this prospective real‐world study, anlotinib demonstrated meaningful efficacy and manageable safety in advanced NSCLC. ABSTRACT Background Anlotinib has shown remarkable efficacy in later‐line treatment of advanced non‐small cell lung cancer (NSCLC).
Jinlin Wang, Youhong Dong, Fengjun Cao, Ruizhi Ran, Yifa Yin, Yinping Li, Yang Fu, Yanhua Xu, Li Kuang, Guiming Chen, Guangqiao Qu, Jun Li, Zhiguo Luo, Qibin Song, Yuan Chen, Xinhua Xu, Tienan Yi, Qian Chu   +17 more
wiley   +1 more source

Hand-foot skin reaction associated with vascular endothelial growth factor receptor tyrosine kinase inhibitors: a FAERS-based pharmacovigilance study. [PDF]

Front Med (Lausanne)
Chen J, Xu Q, Wang B, Sun H, Shu Q.
europepmc   +1 more source

The Aging Microenvironment Shapes Angiogenic Remodeling in IBD‐Associated Colorectal Carcinogenesis

Aging Cell, Volume 25, Issue 6, June 2026.
In IBD, chronic inflammation promotes cellular senescence across epithelial, stromal, endothelial, and immune compartments. The resulting SASP drives pathological angiogenesis, vascular dysfunction, hypoxia, and immune suppression, thereby facilitating progression from inflammation to dysplasia and colitis‐associated colorectal cancer.
Ruoshu Duan, Qingyu Chen, Yuan Xu, Ye Yan, Sujing Jiang   +4 more
wiley   +1 more source

Esaxerenone Attenuates Aldosterone-Induced Renal Fibrosis by Suppressing Fibroblast-to-Lymphatic Endothelial-like Cell Transdifferentiation. [PDF]

Int J Mol Sci
Wang J, Yang S, Wang X, Chang Y, Yang F, Qiang P, Wang X, Shimosawa T, Xu Q, Xiong Y.   +9 more
europepmc   +1 more source

Transcriptomic analysis reveals lipid metabolism and macrophage involvement associated with nintedanib treatment in a rat bleomycin model

British Journal of Pharmacology, Volume 183, Issue 12, Page 3395-3408, June 2026.
In this study, nintedanib reduced lung fibrosis in a rat double‐hit bleomycin‐induced model. Transcriptomic analysis revealed two key gene signatures related to the effect of the molecule: one involving mesenchymal cells affecting known fibrotic pathways and another linking mainly macrophages to lipid metabolism.
Martina Bonatti, Vanessa Pitozzi, Paola Caruso, Silvia Pontis, Maria Gloria Pittelli, Caterina Frati, Denise Madeddu, Federico Quaini, Costanza Anna Maria Lagrasta, Ilaria Minato, Emanuela Bocchi, Maurizio Civelli, Gino Villetti, Marcello Trevisani, Barbara Montanini   +14 more
wiley   +1 more source

Antibody-based regimens targeting PD-1/PD-L1 and VEGF/VEGFR in advanced or metastatic NSCLC: a meta-analysis of RCTs. [PDF]

Front Immunol
Mao W, Tang Z, Chen Y, Chen Y, Zhang S, Feng X, Zhang S.   +6 more
europepmc   +1 more source

When Binding Is Not Blockade: Interpreting IgG4+ T Cells After PD‐1 Therapy

Cancer Science, Volume 117, Issue 6, Page 1766-1768, June 2026.
IgG4 positivity on circulating T cells after PD‐1 therapy may indicate residual antibody binding rather than sustained functional PD‐1 blockade. During sequential ramucirumab plus docetaxel plus G‐CSF treatment, peripheral IgG4+ T‐cell dynamics may also be influenced by redistribution and treatment‐related confounders, limiting direct inference about ...
Man Sun, Dan Zang, Jun Chen
wiley   +1 more source

The Real-World Endocrine Toxicity Profile of ICIs, VEGFR-TKIs, and Their Combination: Analysis of the FDA Adverse Event Reporting System (FAERS) Database. [PDF]

Oncol Res
Marrano N, Caporusso M, Matino C, Caruso I, Ganini C, Rizzo M, Di Gioia L, Cignarelli A, Perrini S, Laviola L, Porta C, Giorgino F, Natalicchio A.   +12 more
europepmc   +1 more source

VEGF‐Positive Mass‐Forming Intrahepatic Cholangiocarcinoma: New Subtype Based on Radiological and Molecular Pathological Analysis

Hepatology Research, Volume 56, Issue 6, Page 976-987, June 2026.
Radiological and molecular pathological investigation of hypervascular intrahepatic cholangiocarcinoma, typically a hypovascular tumor, revealed high VEGF expression, an increase in tumor‐associated arterial vessels, and a strong correlation with favorable prognosis.
Junya Tsuzaki, Naoto Kubota, Shigeyoshi Soga, Yasuhito Arai, Tatsuhiro Shibata, Minoru Esaki, Masahiro Jinzaki, Hidenori Ojima   +7 more
wiley   +1 more source