Results 231 to 240 of about 29,745,998 (266)
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Expression of VEGFR-1 and VEGFR-2 in Degenerative Achilles Tendons
Clinical Orthopaedics and Related Research, 2004Evidence suggests neovascularization is involved in the etiology of spontaneous Achilles tendon rupture. Therefore we investigated expression of the receptors of one of the most important angiogenic factors, the vascular endothelial growth factor in normal and pathologic human Achilles tendons by immunohistochemical and molecular biology methods. Light
Wolf, Petersen +5 more
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The Role of Flt‐1 (VEGFR‐1) in Vascular Morphogenesis
The FASEB Journal, 2007Pathways that shape the first blood vessels to form during development are used subsequently for physiological and pathological angiogenesis. The VEGF‐A signaling pathway affects blood vessel formation in complex ways. Our work focuses on how the flt‐1 (VEGFR‐1) receptor impacts vascular development.
Victoria L Bautch +5 more
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Cediranib targeting of circulating VEGFR-1+ monocyte subpopulations
Journal of Clinical Oncology, 200814687 Background: Recent studies suggest that specific subpopulations of monocytes and myeloid progenitors, particularly those expressing VEGFR-1, play a key role in promoting tumor angiogenesis an...
H. Wu +8 more
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γ-Secretase Regulates VEGFR-1 Signalling in Vascular Endothelium and RPE
2008In conclusion, gamma-secretase is expressed in both retinal microvascular endothelial cells and RPE cells and is able to elicit regulated intramembrane proteolysis of VEGFR1. Furthermore, gamma-secretase regulates the translocation of the intracellular domain of VEGFR1 as well as full length VEGFR1 in both cell types. Gamma-secretase is clearly able to
Michael E, Boulton +3 more
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Chemotherapy Enhances Metastasis Formation via VEGFR-1–Expressing Endothelial Cells
Cancer Research, 2011Abstract Recent studies suggest that chemotherapy, in addition to its cytotoxic effects on tumor cells, can induce a cascade of host events to support tumor growth and spread. Here, we used an experimental pulmonary metastasis model to investigate the role of this host response in metastasis formation.
Laura G M, Daenen +7 more
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Phospho-regulation of the Wnt/_-cat Pathway by VEGFR-1
2013The Wnt/β-catenin (β-cat) signaling cascade is essential to many fundamental processes. Perturbation of this pathway results in various diseases, including colorectal cancer (CRC). Previously, our group identified VEGFR-1 as a positive regulator of β-cat signaling.
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Transcription levels of VEGFR-1 in preterm preeclampsia
American Journal of Obstetrics and Gynecology, 2003Ramen Chmait +3 more
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Recent development of multi-target VEGFR-2 inhibitors for the cancer therapy
Bioorganic Chemistry, 2023Shuo Yuan +2 more
exaly
Macrophage expression of VEGF and VEGFR-1. Potential involvement in atherogenesis
2008The vascular endothelial growth factor (VEGF) family is a group of proteins which contributes to both neovascularisation and inflammation. Elevated levels of VEGF have been found in subjects with atherosclerosis and correlate to several cardiovascular risk factors, e.g. hypertension and hyperlipidemia. The pro-atherogenic effects of VEGF are implied to
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