Discovery of thieno[2,3-<i>d</i>]pyrimidine-based dual Aurora B/VEGFR-2 inhibitors with potent anticancer activity: molecular docking, mechanistic studies, and <i>in vivo</i> validation in a breast cancer model. [PDF]
RSC AdvEl-Shafey HW +8 more
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Mechanistic study of Shenge powder on myocardial hypertrophy and cardiac lymphatic intervention in TAC-induced mouse models. [PDF]
Front PharmacolFan H +8 more
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The Prognostic Value of the Combination of Low VEGFR-1 and High VEGFR-2 Expression in Endothelial Cells of Colorectal Cancer [PDF]
International Journal of Molecular Sciences, 2018 Research on tumor angiogenesis has mainly focused on the vascular endothelial growth factor (VEGF) family and on methods to block its actions. However, reports on VEGF receptor (VEGFR) expression in tumor-associated endothelial cells (ECs) are limited ...
Nicky D’Haene +2 more
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Phospho-regulation of the Wnt/_-cat Pathway by VEGFR-1
, 2013 The Wnt/β-catenin (β-cat) signaling cascade is essential to many fundamental processes. Perturbation of this pathway results in various diseases, including colorectal cancer (CRC). Previously, our group identified VEGFR-1 as a positive regulator of β-cat signaling.
Pan, Mei-Hsiu
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Role of VEGFs/VEGFR-1 Signaling and Its Inhibition in Modulating Tumor Invasion: Experimental Evidence in Different Metastatic Cancer Models [PDF]
International Journal of Molecular Sciences, 2020 Maria Grazia Atzori +2 more
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Serum VEGF‐A and VEGFR‐1 levels in patients with adult immunoglobulin A vasculitis
International Journal of Rheumatic Diseases, 2021AbstractAimImmunoglobulin A vasculitis (IgAV) is classified as a leukocytoclastic vasculitis characterized by immune deposits in endothelial walls of small vessels causing vascular endothelial injury. The aim of the present study is to evaluate levels of vascular endothelial growth factor‐A (VEGF‐A) and VEGF receptor‐1 (VEGFR‐1) levels in adult IgAV ...
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VEGFR-1: A Safe Target for Prophylaxis of Retinopathy of Prematurity?
Pediatric Research, 2004A review of: Shih SC, Ju M, Liu N, Smith LE 2003 Selective stimulation of VEGFR-1 prevents oxygen-induced retinal vascular degeneration in retinopathy of prematurity.
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Angiogenesis-Independent Endothelial Protection of Liver: Role of VEGFR-1
Science, 2003The vascular endothelium was once thought to function primarily in nutrient and oxygen delivery, but recent evidence suggests that it may play a broader role in tissue homeostasis. To explore the role of sinusoidal endothelial cells (LSECs) in the adult liver, we studied the effects of vascular endothelial growth factor (VEGF) receptor activation on ...
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Potential role of soluble VEGFR-1 in antiangiogenesis therapy for cancer
Expert Review of Anticancer Therapy, 2011Antiangiogenesis therapy for cancer may inhibit tumor growth and metastasis when combined with chemotherapy, and has received a great deal of attention over recent years. However, accurate assessments of biological efficacy and toxicity are major hurdles for this approach.
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Expression of VEGFR-1 and VEGFR-2 in Degenerative Achilles Tendons
Clinical Orthopaedics and Related Research, 2004Evidence suggests neovascularization is involved in the etiology of spontaneous Achilles tendon rupture. Therefore we investigated expression of the receptors of one of the most important angiogenic factors, the vascular endothelial growth factor in normal and pathologic human Achilles tendons by immunohistochemical and molecular biology methods. Light
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