Results 31 to 40 of about 700,644 (352)
Machines, 2023 The automotive industry is experiencing increasing competition, and vehicle development is becoming increasingly complex. Manufacturers must therefore be able to rapidly compare the outcomes of experimental tests carried out under different conditions ...
Simone Savant +4 more
doaj +1 more source
Integration of crosswind forces into train dynamic modelling [PDF]
, 2011 In this paper a new method is used to calculate unsteady wind loadings acting on a railway vehicle. The method takes input data from wind tunnel testing or from computational fluid dynamics simulations (one example of each is presented in this article ...
Baker C. J. +8 more
core +1 more source
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Broadband dual-anisotropic solid metamaterials
Scientific Reports, 2017 We have proposed solid elastic metamaterials with anisotropic stiffness and inertial mass simultaneously, denoted as the dual anisotropy, for the potential use of elastic wave controlling.
Yong Cheng, Xiaoming Zhou, Gengkai Hu
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
FSD-BRIEF: A Distorted BRIEF Descriptor for Fisheye Image Based on Spherical Perspective Model
Sensors, 2021 Fisheye images with a far larger Field of View (FOV) have severe radial distortion, with the result that the associated image feature matching process cannot achieve the best performance if the traditional feature descriptors are used.
Yutong Zhang +4 more
doaj +1 more source
, 2018 This paper presents a novel Nonlinear Model Predictive Control (NMPC) scheme for underwater robotic vehicles operating in a constrained workspace including static obstacles.
Heshmati-alamdari, Shahab +3 more
core +2 more sources
Model to predict motion sickness within autonomous vehicles [PDF]
, 2020 Background: Motion sickness is common within most forms of transport; it affects most of the population who experience varied symptoms at some stage in their lives.
Diels, Cyriel +4 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source