Results 31 to 40 of about 88,031 (261)

Research on Reliability Evaluation Method of Aerospace Pyrotechnic Devices Based on Energy Measurement

Applied Sciences, 2020
High reliability is the basic requirement of aerospace pyrotechnic devices. Traditional reliability evaluation methods require a lot of tests, which become too expensive; therefore, the small-sample evaluation method is needed to reduce the cost.
Yubo Zhu, Jili Rong, Qianqiang Song, Zhipei Wu   +3 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Dynamic Modeling and Analysis of Nonlinear Compound Planetary System

Machines, 2022
In the vehicle composite planetary gear transmission system, nonlinear excitations such as time-varying meshing stiffness, backlash and comprehensive error would lead to large vibration and noise, uneven load distribution, unstable operation and other ...
Tingqiong Cui, Yinong Li, Chenglin Zan, Yuanchang Chen   +3 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Fault‐Tolerant Robust Output‐Feedback Control of a Vehicle Platoon Considering Measurement Noise and Road Disturbances

IET Intelligent Transport Systems
As electric vehicle (EV) technology advances, platooning has emerged as a promising strategy to enhance energy efficiency and traffic flow. However, the effective deployment of EV platoons is challenged by the heterogeneous nature of vehicles ...
Fernando Viadero‐Monasterio, Miguel Meléndez‐Useros, Manuel Jiménez‐Salas, María Jesús López Boada   +3 more
doaj   +1 more source

Sound reduction by metamaterial-based acoustic enclosure

AIP Advances, 2014
In many practical systems, acoustic radiation control on noise sources contained within a finite volume by an acoustic enclosure is of great importance, but difficult to be accomplished at low frequencies due to the enhanced acoustic-structure ...
Shanshan Yao, Pei Li, Xiaoming Zhou, Gengkai Hu   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Proposal for objective evaluation criteria for steering feel by steering torque sinusoidal input

Nihon Kikai Gakkai ronbunshu, 2017
The steering feel is an important technical problem for handling and drivability of driver-vehicle system and various kinds of studies have been conducted.
Ikuo KUSHIRO, Keisuke SUZUKI
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Basic study on vertical vibrations suppression in railway vehicle carbody by secondary suspension control using bogie vertical vibration velocity

Nihon Kikai Gakkai ronbunshu
This study investigates a new method for the effective application of active secondary suspension for reducing vertical vibration of the carbody to improve ride comfort of railway vehicles.
Yoshiki SUGAHARA, Ayumi AMANO
doaj   +1 more source