Results 61 to 70 of about 700,644 (352)

The Success of the Light Armoured Vehicle [PDF]

, 2012
Since the 1970s, budget constraints and debates over the tank’s relevance have prompted the Canadian Forces (CF) to pursue lighter, cheaper, and more flexible vehicles.
Maas, Frank
core   +1 more source

The interaction between railway vehicle dynamics and track lateral alignment [PDF]

, 2016
Track geometry deteriorates with traffic flow, thus it needs to be regularly restored using tamping or other method. As the deterioration is mainly in the vertical direction this aspect has been widely studied and models for its analysis developed ...
Cencen Gong, Makoto I, Simon Iwnicki, Yann Bezin   +3 more
core   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Experimental study on interaction between a positive mass and a negative effective mass through a mass–spring system

Theoretical and Applied Mechanics Letters, 2015
We investigate the interaction between a positive mass and a negative effective mass through a three-mass chain connected with elastic springs, a pair of masses is designed to have an effective negative mass, and it interacts with the third positive one ...
Jiao Zhou, Yong Cheng, Hongkuan Zhang, Guoliang Huang, Gengkai Hu   +4 more
doaj   +1 more source

LVD-NMPC: A learning-based vision dynamics approach to nonlinear model predictive control for autonomous vehicles [PDF]

, 2021
Sorin Grigorescu, Cosmin Ginerică, Mihai Zaha, Gigel Măceșanu, Bogdan Trăsnea   +4 more
openalex   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Robust Static Output Feedback Control of a Semi-Active Vehicle Suspension Based on Magnetorheological Dampers

Applied Sciences
This paper proposes a novel design method for a magnetorheological (MR) damper-based semi-active suspension system. An improved MR damper model that accurately describes the hysteretic nature and effect of the applied current is presented.
Fernando Viadero-Monasterio, Miguel Meléndez-Useros, Manuel Jiménez-Salas, Beatriz López Boada   +3 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Avoiding Lyapunov-Krasovskii Functionals: Simple Nonlinear Sampled–Data Control of a Semi-Active Suspension with Magnetorheological Dampers

Machines
This paper presents a novel control design methodology for a magnetorheological (MR) damper-based semi-active suspension system operating under communication-induced time delays, which introduce nonlinear sampled-data dynamics.
Fernando Viadero-Monasterio, Miguel Meléndez-Useros, Manuel Jiménez-Salas, María Jesús López Boada   +3 more
doaj   +1 more source