Results 91 to 100 of about 213,190 (307)

Varanid Lizard Venoms Disrupt the Clotting Ability of Human Fibrinogen through Destructive Cleavage

Toxins, 2019
The functional activities of Anguimorpha lizard venoms have received less attention compared to serpent lineages. Bite victims of varanid lizards often report persistent bleeding exceeding that expected for the mechanical damage of the bite.
James S. Dobson, Christina N. Zdenek, Chris Hay, Aude Violette, Rudy Fourmy, Chip Cochran, Bryan G. Fry   +6 more
doaj   +1 more source

An Appetite for Destruction: Detecting Prey-Selective Binding of α-Neurotoxins in the Venom of Afro-Asian Elapids

Toxins, 2020
Prey-selective venoms and toxins have been documented across only a few species of snakes. The lack of research in this area has been due to the absence of suitably flexible testing platforms.
Richard J. Harris, Christina N. Zdenek, David Harrich, Nathaniel Frank, Bryan G. Fry   +4 more
doaj   +1 more source

Snakebite: An Exploratory Cost-Effectiveness Analysis of Adjunct Treatment Strategies. [PDF]

, 2018
The cost-effectiveness of the standard of care for snakebite treatment, antivenom, and supportive care has been established in various settings. In this study, based on data from South Indian private health-care providers, we address an additional ...
Bulfone, Tommaso C, Herzel, Benjamin J, Kahn, James G, Lewin, Matthew, Raj, C Soundara, Samuel, Stephen P   +5 more
core   +2 more sources

Reconfigurable, Temperature Resilient Phase‐Change Metasurfaces Fabricated via High Throughput Nanoimprinting Lithography

Advanced Science, EarlyView.
ABSTRACT The combination of metasurfaces with chalcogenide phase‐change materials is a highly promising route toward the development of multifunctional and reconfigurable nanophotonic devices. However, their transition into real‐world devices is hindered by several technological challenges. This includes, amongst others, the lack of large area photonic
Carlota de Ruiz de Galarreta, Yinghao Zhao, Jose Mendoza‐Carreño, José M. Caicedo, José Santiso, C. David Wright, M. Isabel Alonso, Jiafang Li, Agustin Mihi   +8 more
wiley   +1 more source

A Taxon-Specific and High-Throughput Method for Measuring Ligand Binding to Nicotinic Acetylcholine Receptors

Toxins, 2019
The binding of compounds to nicotinic acetylcholine receptors is of great interest in biomedical research. However, progress in this area is hampered by the lack of a high-throughput, cost-effective, and taxonomically flexible platform.
Christina N. Zdenek, Richard J. Harris, Sanjaya Kuruppu, Nicholas J. Youngman, James S. Dobson, Jordan Debono, Muzaffar Khan, Ian Smith, Mike Yarski, David Harrich, Charlotte Sweeney, Nathan Dunstan, Luke Allen, Bryan G. Fry   +13 more
doaj   +1 more source

Intra-Specific Venom Variation in the Australian Coastal Taipan Oxyuranus scutellatus

Toxins, 2020
Intra-specific venom variation has the potential to provide important insights into the evolution of snake venom, but remains a relatively neglected aspect of snake venom studies.
Theo Tasoulis, Anjana Silva, Punnam Chander Veerati, Mark Baker, Wayne C. Hodgson, Nathan Dunstan, Geoffrey K. Isbister   +6 more
doaj   +1 more source

Inherently Disordered Auxetic Metamaterials

Advanced Science, EarlyView.
Inherently disordered auxetic metamaterials based on random chiral Delaunay triangulations are designed and investigated using numerical simulations and experimental tests. These disordered frameworks exhibit orthotropic behavior and a large negative Poisson's ratio (ca.
Matteo Montanari, Reza Moghimimonfared, Andrea Spaggiari, Luke Mizzi   +3 more
wiley   +1 more source

Canopy Venom: Proteomic Comparison among New World Arboreal Pit-Viper Venoms

Toxins, 2016
Central and South American pitvipers, belonging to the genera Bothrops and Bothriechis, have independently evolved arboreal tendencies. Little is known regarding the composition and activity of their venoms.
Jordan Debono, Chip Cochran, Sanjaya Kuruppu, Amanda Nouwens, Niwanthi W. Rajapakse, Minami Kawasaki, Kelly Wood, James Dobson, Kate Baumann, Mahdokht Jouiaei, Timothy N. W. Jackson, Ivan Koludarov, Dolyce Low, Syed A. Ali, A. Ian Smith, Andrew Barnes, Bryan G. Fry   +16 more
doaj   +1 more source

Border Terriers under primary veterinary care in England: demography and disorders [PDF]

, 2017
The Border Terrier is a working terrier type that is generally considered to be a relatively healthy and hardy breed. This study aimed to characterise the demography and common disorders of Border Terriers receiving veterinary care in England using de ...
A Agresti, A Egenvall, A Gough, A Tvarijonaviciute, A-S Lequarré, AJ German, AR Boyko, BA Niemiec, BR Kirkwood, C Dedola, C Gorrel, D O'Neill, DD Sleator, DG O'Neill, DG O'Neill, DG O'Neill, DG O'Neill, DG O'Neill, DG O'Neill, DG O'Neill, DG O'Neill, EM Lund, EM Lund, ER Shore, F Mariani, FC Calboli, FE Taylor-Brown, FS Roedler, GJ Patronek, HF Proschowsky, HG Parker, HG Parker, ID Robertson, J Lipton, J Sampson, J Stavisky, J Summers, JF Summers, K Christensen, L Asher, L Kearsley-Fleet, LJ DeBowes, LM Collins, LM Collins, LT Glickman, LT Glickman, M Demirkiran, M Downes, M Ratsitorahina, MD Willard, MJ Mattin, OV Horst, P Bateson, P D’Aquila, P Sandøe, PC Bartlett, PD McGreevy, PE Holt, R Collins, R Johns, RA Packer, RK Wayne, S Acharya, T Lewis, V Black, VJ Adams, W Low   +66 more
core   +2 more sources

An ATP‐Mediated Antibiotic β‐Peptide Nanofiber That Kills Multidrug‐Resistant Bacteria via a Multistage Mechanism

Advanced Science, EarlyView.
The 3K‐AP system forms infinite supramolecular fibrils that undergo controlled degradation into shorter fragments upon enzymatic hydrolysis. Multitechnique imaging reveals a stepwise bacteriolytic mechanism involving bacterial entrapment, disassembly into lethal constructs, and associated extracellular vesicle release, highlighting the dynamic ...
Sohini Chakraborty, Kamal el Battioui, Dániel Molnár, Bálint Jezsó, Lejla Daruka, Tasvilla Sonallya, Tünde Juhász, Rita Hirmondó, Imola Cs. Szigyártó, Loránd Románszki, Natália Tőkési, Daniel Pinkas, Eszter Házy, Olivér Pavela, Andrea Bodor, Zoltán Varga, István Mándity, Mihály Kovács, Csaba Pál, Kata Horváti, Judit Tóth, Tamás Beke‐Somfai   +21 more
wiley   +1 more source