Computational exploration of global venoms for antimicrobial discovery with Venomics artificial intelligence. [PDF]
Nat CommunThe rise of antibiotic-resistant pathogens, particularly gram-negative bacteria, highlights the urgent need for novel therapeutics. Drug-resistant infections now contribute to approximately 5 million deaths annually, yet traditional antibiotic discovery ...
Guan C +3 more
europepmc +2 more sources
Explaining Echis: Proteotranscriptomic Profiling of Echis carinatus carinatus Venom [PDF]
ToxinsSnakebite remains the most neglected tropical disease globally, with India experiencing the highest rates of mortality and morbidity. While most envenomation cases in India are attributed to the ‘big four’ snakes, research has predominantly focused on ...
Salil Javed +6 more
doaj +2 more sources
Megalomyrmex milenae Transcriptome Reveals a Complex Venom Cocktail [PDF]
ToxinsMegalomyrmex ant species have a rich natural history that provides an interesting backdrop to understanding how venom has been shaped by evolution.
Kyle S. Sozanski +4 more
doaj +2 more sources
Insecticidal activity of the linear pseudoscorpion venom peptide Ammogarypin revealed by functional profiling [PDF]
Frontiers in PharmacologySome pseudoscorpions produce venom to subdue prey and their venom components may be of translational interest in agronomy and beyond. However, only very few pseudoscorpion venom peptides have been functionally characterized as of yet.
Maurice Pierry +13 more
doaj +2 more sources
Tropical Medicine and Infectious Disease, 2018 The venom proteome of Siamese Russell’s viper from Taiwan, alongside complementary in vivo lethality neutralization assay and in vitro third-generation antivenomics assessment of the preclinical efficacy of the homologous antivenom manufactured in ...
Libia Sanz +5 more
doaj +2 more sources
Preclinical evaluation of small molecule inhibitors as early intervention therapeutics against Russell’s viper envenoming in India [PDF]
Communications MedicineBackground Snakebites are problematic in many developing regions, including India, where over half of global snakebite deaths occur. Antivenoms are currently the only licensed treatment for snakebites.
Gotravalli V. Rudresha +3 more
doaj +2 more sources
ScorpDb: A Novel Open-Access Database for Integrative Scorpion Toxinology [PDF]
ToxinsScorpion stings are a significant public health concern globally, particularly in tropical and subtropical regions. Scorpion venoms contain a diverse array of bioactive peptides, and different scorpion species around the world typically exhibit varying ...
Masoumeh Baradaran +7 more
doaj +2 more sources
Venomics of Scorpion Ananteris platnicki (Lourenço, 1993), a New World Buthid That Inhabits Costa Rica and Panama [PDF]
ToxinsAnanteris is a scorpion genus that inhabits dry and seasonal areas of South and Central America. It is located in a distinctive morpho-group of Buthids, the ‘Ananteris group’, which also includes species distributed in the Old World.
Cecilia Díaz +8 more
doaj +2 more sources
Venomics of Remipede Crustaceans Reveals Novel Peptide Diversity and Illuminates the Venom’s Biological Role [PDF]
Toxins, 2017 © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Björn von Reumont +14 more
core +2 more sources
Venomics-Accelerated Cone Snail Venom Peptide Discovery [PDF]
International Journal of Molecular Sciences, 2018 Cone snail venoms are considered a treasure trove of bioactive peptides. Despite over 800 species of cone snails being known, each producing over 1000 venom peptides, only about 150 unique venom peptides are structurally and functionally characterized ...
S. Himaya, R. Lewis
semanticscholar +4 more sources